+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Shape memory polymer foams for cerebral aneurysm reparation: effects of plasma sterilization on physical properties and cytocompatibility

, : Shape memory polymer foams for cerebral aneurysm reparation: effects of plasma sterilization on physical properties and cytocompatibility. Acta Biomaterialia 5(5): 1508-1518

Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate, R(r), up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (T(trans)), determined by tandelta peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1 degrees C, for CHEM 3520 and 5520, respectively. The value of T(trans) affects shape memory ability in the recovery test at 37 degrees C, which simulates the behavior after implantation of the device: in fact, R(r) was significantly higher for lower T(trans) foam (R(r) approximately 82% and R(r) approximately 46%, respectively, for CHEM 3520 and CHEM 5520). After plasma sterilization performed by a Sterrad sterilization system, an increase in open porosity was observed: this is probably due to the sterilization cycle; however, no effects on shape recovery behavior were observed. Furthermore, plasma treatment had no significant effect on L929 cells in in vitro cytotoxicity tests, performed on cell culture medium extracts in contact with foams for up to 7 days. Moreover, direct cytocompatibility tests showed a good colonization and growth from L929 cells on CHEM foams, suggesting the effectiveness of an in vivo healing process. All these results seem to suggest that CHEM foams could be advantageously used for manufacturing devices for mini-invasive embolization procedures of aneurysms.


PMID: 19136318

DOI: 10.1016/j.actbio.2008.11.017

Other references

Geiger, J.; Wessels, D.; Lockhart, S.R.; Soll, D.R., 2004: Release of a potent polymorphonuclear leukocyte chemoattractant is regulated by white-opaque switching in Candida albicans. Previous studies employing transmembrane assays suggested that Candida albicans and related species, as well as Saccharomyces cerevisiae, release chemoattractants for human polymorphonuclear leukocytes (PMNs). Because transmembrane assays do not d...

Thompson, R.W., 1943: 2. Mouse control in. Bulletin 436 refers to the common meadow mouse, the only one causing serious damage in Ontario orchards. Control measures consist of: the removal of litter from base of trees; packing 4 in. of cinders or crushed stone around trees, under the guard...

Bailey, B.J.; Briars, G.L., 1996: Estimating the surface area of the human body. A number of formulae have been suggested for estimating the surface area (SA) of a human body from measurements of height H and weight W. Most of these are of the same functional form, namely lmSA = a-0 + a-1lnH + a-2lnW in logarithmic terms, but...

C.J.R.odes; J.E.T.uscott; A.P.M.rtin, 2008: Viral infection as a regulator of oceanic phytoplankton populations. Journal of Marine Systems 74(1-2): 216-226

Minelli, A.; Pasqual, C., 1986: On some abnormal specimens of centipedes (Chilopoda). 8 abnormal specimens are described. A comment is made on the importance of teratology in understanding centipedes morphogenesis.

Cheeniyil, A.; Evani, S.J.; Dallo, S.F.; Ramasubramanian, A.K., 2015: Shear stress upregulates IL-1β secretion by Chlamydia pneumoniae- infected monocytes. Infectious agents are increasingly implicated in the development and progression of chronic inflammatory diseases. Several lines of evidence suggest that the common intracellular respiratory pathogen, Chlamydia pneumoniae contributes to the well-e...

Bagshawe, A.; Taylor, A., 2003: Intractable infertility. Bmj 327(7423): 1098-1100

MacEwan, D.J.; Simpson, J.; Mitchell, R.; Johnson, M.S.; Thomson, F.J.; Fink, G., 1992: Properties and [32P] phosphorylation targets of a novel form of protein kinase C in pituitary. Biochemical Society Transactions 20(2): 133s-133s

King Rowland, 1942: Unusual occurrence of manganese ore. Engineering and Mining Journal 143(9): 52-54

Anthony, H.E., 1917: New fossil Rodents from Porto Rico, with additional notes on Elasmodontomys obliquus Anthony & Heteropsomys insulans Anthony. New York Bulletin of the American Museum of Natural History, 37 183-189