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Significant differences in UK and US female bone density reference ranges


, : Significant differences in UK and US female bone density reference ranges. Osteoporosis International 21(11): 1871-1880

In the United Kingdom (UK), T- and Z-scores are usually calculated using reference ranges derived from United States (US) populations. In the UK arm of a recent randomised trial (International Breast Cancer Intervention Study II (IBIS-II)), substantially, fewer women than expected were recruited into the osteopenic (-2.5<T-score<-1.0) and osteoporotic (T-score<-2.5) arms of the study. The comparison with data from two independent studies showed that UK women aged >45 years with a typical body mass index of 28 kg m(-2) have spine and hip bone mineral density (BMD) 0.6 standard deviation higher than their US counterparts. Dual energy X-ray absorptiometry (DXA) is widely used for the diagnosis of osteoporosis and to investigate the effect of pharmacological treatments on BMD. In both routine and research settings, it is important that DXA results are correctly interpreted. T- and Z-scores for the first 650 UK Caucasian women enrolled in the IBIS-II study were compared with data from two independent studies of unrelated, unselected UK Caucasian women: (1) 2,382 women aged 18 to 79 recruited to the Twins UK Adult Twin Registry; (2) 431 women aged 21 to 84 with no risk factors for osteoporosis recruited at Guy's Hospital. All DXA measurements were performed on Hologic densitometers. Subjects were divided into six age bands, and T- and Z-scores were calculated using the manufacturer's US reference range for the spine and the National Health and Nutrition Examination Survey III reference range for the femoral neck and total hip. The overall mean Z-scores for the IBIS-II, Twin, and Guy's groups were: spine: +0.61, +0.29, +0.33; femoral neck: +0.42, +0.36, +0.45; total hip: +0.65, +0.38, +0.39 (all p<0.001 compared with the expected value of 0). The mean body weight of subjects in the three studies was 74.4, 65.5, and 65.4 kg, respectively. Analysis revealed a highly significant relationship between Z-score and weight at each BMD site with a slope of 0.03 kg(-1). In general, US spine and hip reference ranges are not suitable for the calculation of Z-scores in UK women. For some research study designs, the differences may significantly influence the pattern of subject recruitment.

US$19.90

PMID: 20063090

DOI: 10.1007/s00198-009-1153-1


Other references

Gelbrecht, J.; Richert, A.; Wegner, H., 1995: Habitat requirements of selected endangered or lost butterfly species of the state of Brandenburg (Lep.). The habitat requirements and ecology of most endangered and of several lost Lepidoptera species of the state of Brandenburg (East Germany) are described, based on personal experience of the authors and data from the literature. They are intended t...

Merlani, M.I.; Kemertelidze, E.P.; Popandopoulos, K.; Men'shova, N.I., 2004: Some derivatives of 5alpha-ketosteroid hydrazones: Synthesis from tigogenin and antituberculosis activity. Isonicotinoylhydrazones and thiosemicarbazones of some 5alpha-ketosteroids were synthesized from tigogenin, and their structures were confirmed by NMR and IR spectroscopy and mass spectrometry. Their antimycobacterial activities were studied, and...

Pennick, N.C., 1982: Studies of the external morphology of pyramimonas 6. pyramimonas cirolanae new species. The ultrastructure and scale forms of P. cirolanae sp. nov., are described.

Gollifer D.E.; Brown J.F., 1973: Corn rot of colocasia esculenta caused by fusarium oxysporum. Plant Disease Reporter 57(8): 701-703

Kshetrapal S.; Jain U.; Tanwar T.C., 1979: Micro anatomy and varietal differentiation in crotalaria medicaginea. Geobios (Jodhpur) 6(SUPPL): 323-326

Gloning, S.; Pieper, K.; Zoellner, M.; Meyer-Lindenberg, A., 2017: Electrical impedance tomography for lung ventilation monitoring of the dog. Electrical impedance tomography (EIT) is a radiation free technique which takes advantage of the different electrical conductivities of different tissues. Its main field of application is lung ventilation monitoring. The aim of this prospective st...

Ciaccio, L.L., 1992: Instrumental determination of energy oxygen and BOD-5. Water Science & Technology 26(1-11): 1345-1353

Phillips, P.H.; Kastelic, J.; Hart, E.B., 1948: The effect of mixed tocopherols on milk and butterfat production of the dairy cow. An expt. was set up in which a prepn. containing 1 g. of mixed tocopherols was fed to cows to determine its effect upon milk and butterfat production. The results indicate definitely that the inclusion in the ration of 1 g. of mixed tocopherols da...

Sheppard, T., 1929: Bibliography of Yorkshire geology, 1927 and 1928. Proc Yorkshire Geol Soc 21(3): 288-300

Baylet, R.J.; Gilbert, D.Svallons, Y., 1958: Benign inoculation lymphoreticulosis; case report from Dakar. Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 51(3): 346-350