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Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men

, : Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men. Endocrine Journal 58(5): 335-342

Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and growth hormone (GH) secretion via interaction with the GH secretagogue receptor. Ghrelin molecules are present in two major endogenous forms, an acylated form (ghrelin) and a des-acylated form (des-acyl ghrelin). Recent studies indicated that aerobic exercise did not change plasma total ghrelin levels, however, dynamics of circulating ghrelin and des-acyl ghrelin during aerobic exercise remains unclear. The purpose of this study is to examine the effects of moderate intensity exercise on plasma ghrelin and des-acyl ghrelin concentrations, and to investigate the relationship between ghrelin molecules and other hormonal and metabolic parameters during exercise. Nine healthy males (25.2 ± 0.5 years) exercised for 60 min at 50% of their maximal oxygen consumptions. We measured the plasma concentrations of ghrelin, des-acyl ghrelin, GH, norepinephrine (NE), epinephrine (E), dopamine (DA), insulin, and glucose. Plasma ghrelin level significantly decreased during exercise, whereas plasma des-acyl ghrelin and total ghrelin levels did not change. Plasma NE, E, DA and GH levels were significantly increased during exercise. Plasma insulin level significantly decreased during exercise, and plasma glucose levels remained steady during exercise. NE, E, DA, and GH were correlated negatively with plasma ghrelin levels. These findings suggest that acute moderate exercise may suppress ghrelin release from the stomach, decrease ghrelin O-acyltransferase activity, and/or activate ghrelin utilization in peripheral tissues and that exercise-induced ghrelin suppression may be mediated by activated adrenergic system.


PMID: 21436599

Other references

Schnell, H.; Greif, J., 1974: Diurnal variations in the physiological motility of human teeth. Deutsche Zahnarztliche Zeitschrift 29(9): 879-880

Sandionigi, A.; Galimberti, A.; Labra, M.; Ferri, E.; Panunzi, E.; D.M.ttia, F.; Casiraghi, M., 2012: Analytical approaches for DNA barcoding data – how to find a way for plants?. Identification of living beings is a core problem in biology. Identification can be achieved by several methods, but in recent decades, molecular techniques have become more and more common. DNA barcoding is an initiative that was launched less th...

Kernodle, D.S.; Mcgraw, P.A.; Barg, N.L.; Harshman, S., 1992: Subinhibitory nafcillin induces Staphylococcus aureus alpha-toxin production and enhances lethality. Clinical Research 40(4): 848A

Schaftenaar, Willem, 2001: Vaccination of non-domestic carnivores: A problematic obligation. Infectious diseases pose a risk to non-domestic captive carnivores. Since commercially available vaccines are not always safe for non-domestic species, they cannot be used without testing them for safety and efficacy. A short list of diseases for...

Gang, Y.; Keeling, P.J.; Goldman, J.H.; Hnatkova, K.; Bent, S.; Mckenna, W.J.; Malik, M., 1995: Time domain and Spectral Turbulence Analysis of Signal Averaged electrocardiography as Prognostic Determinants in Idiopathic Dilated Cardiomyopathy. Journal of the American College of Cardiology 0(SPEC ISSUE): 215A

Jasko T., 1990: Petroleum prospect size estimation by numerical methods. Computers and Geology 7: 339-346

Kragh-Hansen, U.; Brennan, S.O.; Galliano, M.; Sugita, O., 1990: Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations. Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb)were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally char...

S.A.H.sseini Boldaji; R.A.K.avari-Nejad; R.H.ssan Sajedi; H.F.himi; S.S.adatmand, 2012: Water availability effects on antioxidant enzyme activities, lipid peroxidation, and reducing sugar contents of alfalfa Medicago sativa L. To understand alfalfa (<i>Medicago sativa</i> L.) reactions to osmotic stress, solutions with ?.5, ?1 and ?1.5 MPa osmotic potentials using PEG (Poly ethyleneglycol) and distilled water as control were prepared. In a germination test,...

Soares, J.H.Jr, 1990: An overview of calcium and phosphorus in feedstuffs. Methods used to estimate the availability of calcium and phosphorus in feeds are reviewed.

Zhang, Q.; Qu, Y.; Li, Z.; Zhang, Q.; Xu, M.; Cai, X.; Li, F.; Lu, L., 2016: Isolation and Culture of Single Cell Types from Rat Liver. There have been few reports on the simultaneous isolation of multiple liver cell populations thus far. As such, this study was aimed at establishing a protocol for the simultaneous separation of hepatocytes (HCs), hepatic stellate cells (HSCs), li...