geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system


, : Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system. Acta Biomaterialia 9(7): 7469-7479

Composite orthopaedic coatings with antibacterial capability containing chitosan, Bioglass® particles (9.8μm) and silver nanoparticles (Ag-np) were fabricated using a single-step electrophoretic deposition (EPD) technique, and their structural and preliminary in vitro bactericidal and cellular properties were investigated. Stainless steel 316 was used as a standard metallic orthopaedic substrate. The coatings were compared with EPD coatings of chitosan and chitosan/Bioglass®. The ability of chitosan as both a complexing and stabilizing agent was utilized to form uniformly deposited Ag-np. Due to the presence of Bioglass® particles, the coatings were bioactive in terms of forming carbonated hydroxyapatite in simulated body fluid (SBF). Less than 7wt.% of the incorporated silver was released over the course of 28days in SBF and the possibility of manipulating the release rate by varying the deposition order of coating layers was shown. The low released concentration of Ag ions (<2.5ppm) was efficiently antibacterial against Staphyloccocus aureus up to 10days. Although chitosan and chitosan/Bioglass® coating supported proliferation of MG-63 osteoblast-like cells up to 7days of culture, chitosan/Bioglass®/Ag-np coatings containing 342 μg of Ag-np showed cytotoxic effects. This was attributed to the relatively high concentration of Ag-np incorporated in the coatings.

US$19.90

PMID: 23511807

DOI: 10.1016/j.actbio.2013.03.006


Other references

Lee, C.H.; Edwards, A.M., 2001: Stimulation of DNA synthesis and c-fos mRNA expression in primary rat hepatocytes by estrogens. The mechanism(s) of tumour promotion in liver by estrogens is not well understood although growth stimulation is known to be one important element of their action. As a basis for studying mechanisms of growth control by estrogens, effects of both...

Zakrzewski; Delande; Gay; Rzazewski, 1993: Ionization of highly excited hydrogen atoms by a circularly polarized microwave field. Physical Review. A, Atomic, Molecular, and Optical Physics 47(4): R2468-R2471

Baergen, E.H., 1972: Superannuation in Canada. Lancet 2(7772): 336-336

Kirmayer, L.J., 2013: The cultural diversity of healing: meaning, metaphor,and mechanism. Heart Views 14(1): 39-40

Maenhout, C.A.A., 1978: Eyespot disease in winter wheat. An evaluation of the control recommendations from 1974 to 1977. Investigations on eyespot disease [Pseudocercosporella herpotrichoides] in winter wheat indicated that infection in mid-April or later had little effect on grain yields. Results of experiments in 1972-4 showed that benomyl applied to crops with 14...

Klingler, C.H.; Remzi, M.; Marberger, M.; Janetschek, G., 2006: Haemostasis in laparoscopy. Objective: Adequate haemostasis is essential for advanced laparoscopic procedures since uncontrolled bleeding may cause significant complications and even required converting to laparotomy to obtain sufficient haemostasis. The aim of this review...

Kirby, R., 2000: Practical implications of tidal flat shape. Arising from high precision empirical measurements of whole shore shape involving determination of incremental areas in narrow height bands undertaken during the 1980s, now confirmed by physical and mathematical models and theoretical studies, it...

Russo, F.; D.B.lla, S.; Nigita, G.; Macca, V.; Laganà, A.; Giugno, R.; Pulvirenti, A.; Ferro, A., 2013: miRandola: extracellular circulating microRNAs database. MicroRNAs are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular messenger RNAs. They are frequently dysregulated in cancer and have shown great potential as t...

Steely, W.M.; Davies, R.S.; Brigham, R.A., 1987: Carotid body tumor and hyperparathyroidism. A case report and review of the literature. Carotid body tumor is an uncommon tumor of the head and neck. The coexistence of this entity with primary hyperparathyroidism is even more unusual, with only four cases having been previously recorded. This report describes a patient with a left i...

Suda, T.; Iwata, N.; Yamada, K., 1976: Studies on the absorption behavior of aldrin dieldrin and endrin located in soil by cucumber using the cucurbitaceae as stock. The absorbing rate of dieldrin in cucumber (Cucumis sativus) fruits harvested in summer was higher than that in autumn. The cucumber harvested in summer was grafted on the squash (Cucurbita spp.) stocks ('Kurodane' or 'Tetsukabuto&a...