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Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection


, : Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. Journal of Immunology 184(9): 4679-4687

Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers. The function of sCD127 and whether it influences IL-7 bioavailability or activity is unknown. In this study, we demonstrated that recombinant and native sources of sCD127 significantly inhibited IL-7-mediated STAT5 and Akt phosphorylation in CD8(+) T cells. IL-7-mediated proliferation and Bcl-2 expression were similarly reduced by sCD127. In each case, native sCD127 inhibited IL-7 activity to a greater degree than rsCD127. Anti-IL-7 activity was inherent to human plasma and could be reversed by depletion of CD127, revealing for the first time the biological activity of naturally occurring sCD127. Plasma sCD127 concentrations were increased in HIV(+) individuals compared with HIV(-) controls, correlated with IL-7 levels, and remained unchanged in HIV(+) individuals following 1 y of effective antiretroviral therapy. Determining the regulation and function of sCD127 may be critical for understanding both the pathogenesis of diseases in which IL-7 likely has a role (e.g., HIV infection, cancer) and its potential impact on IL-7 as a therapeutic approach.

US$19.90

PMID: 20304824

DOI: 10.4049/jimmunol.0903758


Other references

Jones, Jg, 1972: Studies on freshwater bacteria: Association with algae and alkaline phosphatase activity. Journal of ecology: 60 (1) 59-75

Berget, S.M., 1984: Are U4 small nuclear ribonucleoproteins involved in polyadenylation?. The mechanism whereby eukaryotic pre-messenger RNAs are polyadenylated is unknown. Most models for polyadenylation invoke cleavage of precursor transcripts at the site of poly(A) addition followed by polymerization of A residues by poly(A) polymer...

Cicinelli, E.; Schonauer, L.M.; Galantino, P.; Matteo, M.G.; Cassetta, R.; Pinto, V., 2000: Mechanisms of uterine specificity of vaginal progesterone. Endometrial transformations achieved by vaginal progesterone exceed those normally expected from the circulating concentrations obtained, this suggests some degree of direct vagina to uterus transport. We speculate on the different mechanisms invo...

Ozbek, O.; Nayman, A.; Koç, O.; Küçükapan, A.; Ozbek, S.; Kerimoğlu, Uü., 2012: Radiofrequency ablation of phalangeal osteoid osteoma: technical challenges encountered in small bones. Osteoid osteoma, a benign bone tumor, is characterized by a generally less than 1 cm nidus surrounded by a zone of reactive sclerosis. It is frequently located in the femur and tibia; on the other hand in up to 5% of cases it may be presented in u...

Setbon, L., 1969: Oral treatment of intestinal atonia after appendectomy by the simultaneous administration of metochlopramide and sorbitol. Therapeutique 45(2): 203-205

D.P.eez, L.H.; Kok, D.J., 1997: Supporting experimental evidence of host specificity among southern African polystomes. Although monogeneans of anurans are generally regarded as host-specific, there is a lack of conclusive experimental evidence. Infection and cross-infection experiments were conducted with oncomiracidia of Polystoma australis and P. marmorati. In a...

Hosea, N.A.; Guengerich, F.P., 1998: Oxidation of nonionic detergents by cytochrome P450 enzymes. Nonionic phenolic detergents are commonly used in the purification of membrane-associated proteins. Triton N-101 was shown to be oxidized by NADPH-fortified human liver microsomes and recombinant human cytochromes P450 (P450). Oxidation was monito...

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Brunner, L.J.; Munar, M.Y.; Vallian, J.; Wolfson, M.; Stennett, D.J.; Meyer, M.M.; Bennett, W.M., 1998: Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients. Study Objective. To examine the effect of the concurrent administration of increasing amounts of grapefruit juice, an inhibitor of drug metabolism, on the steady-state pharmacokinetics of cyclosporine. Design. Open-label, three-period crossover, f...