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Sorafenib: activity and clinical application in patients with hepatocellular carcinoma

, : Sorafenib: activity and clinical application in patients with hepatocellular carcinoma. Expert Opinion on PharmacoTherapy 12(2): 303-313

Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results. Sorafenib is the first compound to demonstrate a significant effect on survival in HCC. Our experience in the clinical application of sorafenib is reviewed in conjunction with relevant publications in the literature. Based on ex vivo and in vivo experiments, we conclude that sorafenib plays an important role in blocking tumor cell proliferation, inducing apoptosis, and reversing multidrug resistance. Antitumor activities were observed in multiple tumor types in ongoing randomized Phase III studies. Toxicity was observed as tolerable. On 16 November 2007, sorafenib was approved by the United States Food and Drug Administration for the treatment of unresectable HCC, based on the results of an international, multicenter, randomized, double-blind, placebo-controlled trial in patients with unresectable, biopsy-proven HCC. With the approval of sorafenib being given the significance of a milestone, systemic treatment of HCC is no longer regarded as ineffective. The tyrosine kinase inhibitor, sorafenib, gives us new hope for successful cancer therapy.


PMID: 21226640

DOI: 10.1517/14656566.2011.546346

Other references

Kjorsvik, E.; Pittman, K.; Pavlov, D., 2004: From fertilisation to the end of metamorphosis - functional development. Unknown

Takeshita, Y.J.; Tan Boon Ann; Arshat, H., 1986: Attitudes towards induced abortion in Peninsular Malaysia--a Guttman scale analysis. The data for this study are from the 1974 Malaysian Fertility and Family Survey. The analysis focuses on the responses given by about 6000 women to the question whether they would approve or disapprove of induced abortion under each of the followi...

Monaco, Bruno, 1939: Effect of short exposures to high altitude on bactericidal potencies of whole blood of guinea-pigs. Whole blood of healthy guinea-pigs usually possesses bactericidal power which is high for some strains of Escherichia coli, moderate for the Staphylococci, and null for Eberthella typhosa, Bacillus anthracis and the Streptococci. Bactericidal pote...

Luby, S.P.; Agboatwalla, M.; Hoekstra, R.M., 2011: The variability of childhood diarrhea in Karachi, Pakistan, 2002-2006. Diarrhea burden is often estimated using cross-sectional surveys. We measured variability in diarrhea prevalence among children < 5 years of age living in squatter settlements in central Karachi, Pakistan. We pooled data from non-intervention c...

Söderbäck, M.; Hansson, E.; Tottmar, O.; Rönnbäck, L., 1989: Neurons in primary cultures from five defined rat brain regions--cellular composition and morphological appearance. Primary cultures from 15-17 days old fetal rat cerebral cortex, striatum, hippocampus, substantia nigra and brain stem were grown for ten days. Cell aggregates were formed one to two days after seeding. The cell bodies migrated peripherally from t...

Ennals, 1978: Mr Ennals attacks industrial action and ill-informed criticism of the national health service. Hospital and Health Services Review 74(4): 129-130

Mainzer, F., 1973: Herniation of the nucleus pulposus. A rare complication of intervertebral-disk calcification in children. Radiology 107(1): 167-170

Dong, J.; Shokes, J.E.; Scott, R.A.; Lynn, D.G., 2006: Modulating amyloid self-assembly and fibril morphology with Zn(II). Metal ions (Zn(II)) are demonstrated as probes of amyloid structure in simple segments of the Abeta peptide, Abeta(13-21). By restricting the possible metal binding sites to His13/His14 dyad, we show that Zn2+ can specifically control the rate of...

Voss, L.M.; Rhodes, K.H., 1992: Leukocyte adhesion deficiency presenting with recurrent otitis media and persistent leukocytosis. Clinical Pediatrics 31(7): 442-445

Fehling, E.; Schonwiese, S.; Klein, E.; Mukherjee, K.D.; Weber, N., 1998: Preparation of malvalic and sterculic acid methyl esters from Bombax munguba and Sterculia foetida seed soils. A method has been developed for the preparation of highly pure malvalic (cis-8,9-methyleneheptadec-8-enoic) and sterculic (cis-9,10-methyleneoctadec-9-enoic) acid methyl esters starting from Bombax munguba and Sterculia foetida seed oils. The meth...