geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Spatiotemporal dynamics of low frequency BOLD fluctuations in rats and humans


, : Spatiotemporal dynamics of low frequency BOLD fluctuations in rats and humans. Neuroimage 54(2): 1140-1150

Most studies involving spontaneous fluctuations in the BOLD signal extract connectivity patterns that show relationships between brain areas that are maintained over the length of the scanning session. In this study, however, we examine the spatiotemporal dynamics of the BOLD fluctuations to identify common patterns of propagation within a scan. A novel pattern finding algorithm was developed for detecting repeated spatiotemporal patterns in BOLD fMRI data. The algorithm was applied to high temporal resolution T2*-weighted multislice images obtained from rats and humans in the absence of any task or stimulation. In rats, the primary pattern consisted of waves of high signal intensity, propagating in a lateral to medial direction across the cortex, replicating our previous findings (Majeed et al., 2009a). These waves were observed primarily in sensorimotor cortex, but also extended to visual and parietal association areas. A secondary pattern, confined to subcortical regions consisted of an initial increase and subsequent decrease in signal intensity in the caudate-putamen. In humans, the most common spatiotemporal pattern consisted of an alteration between activation of areas comprising the "default-mode" (e.g., posterior cingulate and anterior medial prefrontal cortices) and the "task-positive" (e.g., superior parietal and premotor cortices) networks. Signal propagation from focal starting points was also observed. The pattern finding algorithm was shown to be reasonably insensitive to the variation in user-defined parameters, and the results were consistent within and between subjects. This novel approach for probing the spontaneous network activity of the brain has implications for the interpretation of conventional functional connectivity studies, and may increase the amount of information that can be obtained from neuroimaging data.

US$19.90

PMID: 20728554

DOI: 10.1016/j.neuroimage.2010.08.030


Other references

Finke, Peter., 2004: A short note on the situation of the Natural History organizations in Germany Kurzinformation zur Situation der Naturwissenschaftlichen Vereine bzw Naturforschenden Gesellschaften in Deutschland. The article informs about and critically evaluates the present situation of a special type of German natural history organisations. The "Dachverband der Naturwissenschaftlichen Vereinigungen Deutschlands" DNVD e.V. intends to represent t...

Liu, H.; Jin, Z.; Deng, Y.; Jing, L., 2015: Dual-axis rotational coronary angiography can reduce peak skin dose and scattered dose: a phantom study. The purpose of this study was to evaluate peak skin dose received by the patient and scattered dose to the operator during dual-axis rotational coronary angiography (DARCA), and to compare with those of standard coronary angiography (SA). An anthr...

Anonymous, 1962: Annual Report of the Director of Agriculture and Fisheries for the year 1961. Under the heading Entomology, plant pathology and other investigations, pp. 5-7, studies are reported on Clastoptera undulala, a pest of casuarina; lures for Mediterranean fruit fly; biological control of whitefly (Metaleurodicus cardini) and othe...

Gomes, R.V.; Cunha, V.C.R.; Zourdos, M.C.; Aoki, M.S.; Moreira, A.; Fernandez-Fernandez, J.; Capitani, C.D., 2016: Physiological Responses of Young Tennis Players to Training Drills and Simulated Match Play. The aim of this study was to investigate the responses of young tennis players during 5 different training drills and to compare the responses between drills. Ten (17.0 ± 1.2 years) male tennis players participated in this study. Each athlete com...

Rewald, E.; Francischetti, M.M.; Barberis, L., 2002: High dose intravenous immunoglobulin repertoire versus anti-D. Disproportions in quantity and quality. Here we consider certain therapeutic effects that intravenous administration of pooled high dose immunoglobulin and anti-D IgG share. Despite million-fold difference in doses such an effect occurs at least in idiopathic thrombocytopenic purpura (I...

Mangone, L.; Minicozzi, P.; Vicentini, M.; Giacomin, A.; Caldarella, A.; Cirilli, C.; Falcini, F.; Giorgi Rossi, P.; Sant, M., 2013: Key factors influencing lung cancer survival in northern Italy. <italic>Aim</italic>: Lung cancer is a major cause of cancer death worldwide. The aims of this study were to analyze presentation, treatment and survival for lung cancer in northern Italy, and identify factors influencing survival. <...

Yang, X-yu., 2004: Comment on intra-arterial interventional techniques in the diagnosis and treatment of obstetrical and gynecological diseases. Zhonghua Fu Chan Ke Za Zhi 39(2): 73-75

Donzelli, S.; Zaina, F.; Lusini, M.; Minnella, S.; Respizzi, S.; Balzarini, L.; Poma, S.; Negrini, S., 2016: The three dimensional analysis of the Sforzesco brace correction. Scoliosis is a three dimensional deformity, and brace correction should be 3D too. There is a lack of knowledge of the effect of braces, particularly in the sagittal and transverse plane. The aim of this study is to analyse the Sforzesco Brace cor...

Okhuysen, P.C.; Chappell, C.L.; Kettner, C.; Sterling, C.R., 1996: Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation. Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1...

Michot Jean, 1958: Les plagioclases du massif anorthosito-noritique de Haaland, Egersund (Norvege). Describes the plagioclase feldspars in the anorthosites and leuconorites that form the northern margin of the Haaland massif in Egersund, Norway. Two types of plagioclase are recognized. Those of the first type occur in larger crystals of irregula...