+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction

, : Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology 30(4): 749-757

Animal and clinical studies have suggested that polyphenols in fruits, red wine, and tea may delay the development of atherosclerosis through their antioxidant and anti-inflammatory properties. We investigated whether individual dietary polyphenols representing different polyphenolic classes, namely quercetin (flavonol), (-)-epicatechin (flavan-3-ol), theaflavin (dimeric catechin), sesamin (lignan), or chlorogenic acid (phenolic acid), reduce atherosclerotic lesion formation in the apolipoprotein E (ApoE)(-/-) gene-knockout mouse. Quercetin and theaflavin (64-mg/kg body mass daily) significantly attenuated atherosclerotic lesion size in the aortic sinus and thoracic aorta (P<0.05 versus ApoE(-/-) control mice). Quercetin significantly reduced aortic F(2)-isoprostane, vascular superoxide, vascular leukotriene B(4), and plasma-sP-selectin concentrations; and augmented vascular endothelial NO synthase activity, heme oxygenase-1 protein, and urinary nitrate excretion (P<0.05 versus control ApoE(-/-) mice). Theaflavin showed similar, although less extensive, significant effects. Although (-)-epicatechin significantly reduced F(2)-isoprostane, superoxide, and endothelin-1 production (P<0.05 versus control ApoE(-/-) mice), it had no significant effect on lesion size. Sesamin and chlorogenic acid treatments exerted no significant effects. Quercetin, but not (-)-epicatechin, significantly increased the expression of heme oxygenase-1 protein in lesions versus ApoE(-/-) controls. Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1. These data suggest that the cardiovascular protection associated with diets rich in fruits, vegetables, and some beverages may in part be the result of flavonoids, such as quercetin.


PMID: 20093625

DOI: 10.1161/ATVBAHA.109.199687

Other references

Heere, L.J.; Karam, J.D., 1975: Analysis of expression of the rII gene function of bacteriophage T4. Temperature-sensitive (ts) mutants of the T4 phage rII gene were islated and used in temperature shift experiments that revelaed two different expressions for the normal rII (rII+) gene function in vivo: (i) an early expression (0 to 12 min postin...

Hamel R.; Ford Hutchinson A.W., 1987: Pharmacologic modification of particulate antigen induced pulmonary late responses in rats. American Review of Respiratory Disease 135(4 PART 2): A396

Burgess L., 1971: Neuro secretory cells and their axon pathways in culiseta inornata diptera culicidae. Canadian Journal of Zoology 49(6): 889-901

Wills-Karp, M., 2011: Allergen-specific pattern recognition receptor pathways. Allergic diseases continue to plague modernized societies, underscoring the need to identify the molecular basis for the propensity of a small number of environmental proteins to provoke maladaptive, allergic responses. Recent data suggest that th...

Dilovski, M.T.kerlekov, P., 1978: Serologic methods for the comple. Veterinarno meditsinski nauki Veterinary science5(4): 20-26

Bagchi, S., 2007: Alemtuzumab shows promise for CLL. Lancet. Oncology 8(12): 1060-1060

Fabre, M., 1950: Indications of sodium chloride cure in gynecology. Comptes Rendus de la Societe Francaise de Gynecologie 20(3): 67-68

Tashani, O.A.; AlAbas, O.A.; Kabil, R.A.M.; Johnson, M.I., 2016: Psychometric Properties of an Arabic Pain Anxiety Symptoms Scale-20 (PASS-20) in Healthy Volunteers and Patients Attending a Physiotherapy Clinic. The aim of this study was to cross-culturally adapt the PASS-20 questionnaire for use in Libya. Participants were 71 patients (42 women) attending the physiotherapy clinic, Ibn Sina Hospital, Sirt, Libya for management of persistent pain and 137 h...

Abdulkhasanov, A.A., 1981: Routes of human tick-borne spirochetosis in the Fergana Valley. Meditsinskaia Parazitologiia i Parazitarnye Bolezni 50(3): 21-23

Sprent, J.F.A., 1960: Parasitism. An introduction to parasitology and immunology for students of biology, veterinary science, and medicine. This book will be interesting and informative to all concerned with parasitology. Sprent discusses with skill parasitism in its conventional sense but introduces the discipline of immunity into his considerations. This he does rightly since in all...