+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case

, : Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case. Neuropathology 29(5): 574-578

Cerebral and spinal location of glioneuronal tumors have been recently described as a novel type of primary CNS neoplasia. A distinctive rare form of glioneuronal tumors with neuropil-like islands (GTNI) have been reported to occur in the adult cerebrum, whereas spinal GTNI localization is extremely rare. In the present report we describe a case of a 15-month-old child with a spinal GTNI of the cervical region and meningeal dissemination. Histologically the tumor was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers. Cerebral GTNI shows abundant glial components not rarely exhibiting anaplastic features that justify their inclusion within the group of diffuse astrocytomas. In contrast, including our case, spinal GTNI do not show histological evidence of anaplastic features and exhibits a significant neuronal component that may imply considering these lesions in a separate group. Nevertheless, due to their exceptional rarity, the natural history of these lesions is not yet fully understood, but spinal GTNI seems to have an unfavorable clinical course despite their benign histopathological features, which must be taken into account for appropriate treatment and follow-up of the patient.


PMID: 19077041

DOI: 10.1111/j.1440-1789.2008.00988.x

Other references

Ojeda, S.; Lloret, M.; Naranjo, A.; Déniz, F.; Chesa, N.; Domínguez, C.; Lara, P.C., 2017: Androgen deprivation in prostate cancer and the long-term risk of fracture. To determine the rate of bone mass loss and the risk of fracture induced by androgen deprivation therapy in patients with prostate cancer. Prospective study in 2 phases. In the first phase, demographic variables, FRAX<sup>®</sup>, bon...

Ali, S.; Khan, M.Alam.; Khealani, B., 2006: Limb-shaking Transient Ischemic Attacks: case report and review of literature. Limb shaking Transient Ischemic Attack is a rare manifestation of carotid-occlusive disease. The symptoms usually point towards a seizure like activity and misdiagnosed as focal seizures. On careful history the rhythmic seizure like activity revea...

Miller, Y.E., 1990: Bombesin-like peptides: from frog skin to human lung. American Journal of Respiratory Cell and Molecular Biology 3(3): 189-190

Heikal, L.; Starr, A.; Martin, G.P.; Nandi, M.; Dailey, L.Ann., 2016: In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice. S-nitrosophytochelatins (SNOPCs) are novel analogues of S-nitrosoglutathione (GSNO) with the advantage of carrying varying ratios of S-nitrosothiol (SNO) moieties per molecule. Our aim was to investigate the in vivo pharmacological potency and bi...

Gajić, G.; Mitrović, M.; Pavlović, P.; Stevanović, B.; Djurdjević, L.; Kostić, O., 2009: An assessment of the tolerance of Ligustrum ovalifolium Hassk. to traffic-generated Pb using physiological and biochemical markers. This study examined the leaf Pb content, chlorophyll fluorescence parameters (Fo, Fm, Fv, Fv/Fm, Fm/Fo and t(1/2)), photopigments (Chl a, Chl b, Chl a+b, the Chl a/b ratio, and total carotenoids), as well as total phenolics (free and bound) in pri...

Grimes, D.S.; Hindle, E.; Dyer, T., 1998: Albanian paradox, another example of protective effect of Mediterranean lifestyle?. Lancet 351(9105): 835-836

Cooke, J.A.L.; Merrett, P., 1967: The rediscovery of Lessertiella saxetorum in Britain (Araneae: Linyphiidae). Journal of Zoology London, 151: 323-328

Wolańska, M.; Bakunowicz-Lazarczyk, A.; Bańkowski, E.; Stankiewicz, A., 1995: Cathepsin D and an alkaline protease activities in subretinal fluid. It was found that subretinal fluid contains at least two different proteolytic enzymes which digest various protein substrates. The main of them was identified as cathepsin D. This protease is very active towards the denatured haemoglobin. The hig...

Y.Y.X.; Zou M J., 1988: Description of atrichopogon pallidicillus new species and their intersex diptera ceratopogonidae. In this paper a new species and intersex of Atrichopogon (Psilokempia) [A. pallidicillus, sp. nov.] from Yunnan Province [China] are discribed. The type specimens are deposited in the Institute of Microbiology and Epidemiology, Academy of Military...

Marino, I.R.; Roth, A.E.; Rees, M.A.; Doria, C., 2017: Open dialogue between professionals with different opinions builds the best policy. American Journal of Transplantation 17(10): 2749-2749