geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sudden deaths in psychiatric patients


, : Sudden deaths in psychiatric patients. Journal of Clinical Psychiatry 72(7): 936-941

Studies using death certificates have indicated an excess of sudden cardiac deaths among users of antipsychotic drugs compared to the general population, but they may have underestimated the presence of other known causes of sudden and unexpected death. To assess the causes and risk factors for sudden death discovered by contemporaneous investigation of all deaths occurring over a 26-year period (1984-2009) in adults (119,500 patient-years) receiving care in one large psychiatric hospital in New York. Circumstances of death, psychiatric diagnoses, psychotropic drugs, and past medical history were extracted from the root cause analyses of sudden, unexpected deaths. After cases involving suicide, homicide, and drug overdoses were excluded, the remaining explained and unexplained cases of sudden death were compared regarding clinical variables and the utilization of antipsychotics. One hundred cases of sudden death were identified. The death remained unexplained in 52 cases. The incidence of unexplained sudden death per 100,000 patient-years increased from 7 (95% CI, 3.7-19.4) in 1984-1998 to 125 (95% CI, 88.9-175.1) in 2005-2009. Explained and unexplained cases were similar regarding psychiatric diagnoses and use of all psychotropic classes, including first- and second-generation antipsychotics. Dyslipidemia (P = .012), diabetes (P = .054), and comorbid dyslipidemia and diabetes (P = .006) were more common in the unexplained group. In a consecutive cohort of psychiatric patients, the unexplained sudden deaths were not associated with higher utilization of first- or second-generation antipsychotics. The role of diabetes and dyslipidemia as risk factors for sudden death in psychiatric patients requires careful longitudinal studies.

US$19.90

PMID: 21672496

DOI: 10.4088/JCP.10m06244gry


Other references

Hooks, R.; Roberts, J., 2007: Older peoples' personal care needs: an analysis of care provision: care provision and the roles of key healthcare personnel. Aims and Objectives.  The study aimed to investigate and evaluate the provision of personal care for older patients within the acute care setting. Specific objectives included: (i) exploration of older peoples' perceptions of personal care...

Boutin, Y.; Leitenberg, D.; Tao, X., 1997: Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets. Journal of Immunology 159: 02-9

Curtiss, L.K.; Edgington, T.S., 1982: Immunochemical heterogeneity of human plasma apo lipo protein b 1. apo lipo protein b binding of mouse hybridoma antibodies. Apolipoprotein B [apoB] obtained from each of the major density classes of human plasma lipoproteins was investigated immunochemically. Different mouse hybridoma cell lines (11) were generated and selected on the basis of their ability to secrete...

Kubwalo, H.W.; Muula, A.S.; Siziya, S.; Pasupulati, S.; Rudatsikira, E., 2014: Prevalence and correlates of being bullied among in-school adolescents in Malawi: results from the 2009 Global School-Based Health Survey. Physical and emotional violence against adolescents is a neglected, but growing problem globally. Violence against adolescents negatively affects the victim in terms of physical health, school attendance and performance and social adjustment. The...

Taranenko, L.D.; Medvedenko, A.F., 1989: Intensive care in surgical services for patients with acute pancreatitis. Intensification of specialized aid to the patients with acute pancreatitis, improvement of the existing methods for diagnosis and treatment, and development of the new ones permitted to reduce the total, postoperative lethality and mean duration o...

Hendrickx, P.; Luska, G.; Laas, J.; Haverich, A., 1986: I.v. DSA in the diagnosis and follow-up of thoracic aortic dissection. Intravenous DSA was performed in 53 patients with suspected dissection of the thoracic aorta and in 13 patients following surgery for aortic dissection. In 36 patients, the suspected diagnosis could be excluded definitely and, in 14 cases out of 1...

Izumi Y.; Sato K.; Tani Y.; Ogata K., 1973: Distribution of 7 keto 8 amino pelargonic acid synthetase in bacteria and the control mechanism of the enzyme activity. Agricultural & Biological Chemistry 37(6): 1335-1340

Good, M., D.; Gilkey, R., J., 1996: Sound localization in noise: The effect of signal-to-noise ratio. The sound localization ability of human observers has been frequently examined in quiet environments, but there have been relatively few studies that have considered the effect of noise on sound localization. In this study, three subjects judged t...

Ping LiYan; Shen YingBai; Jin YouJu, 2001: Volatiles released in succession from artificially damaged ashleaf maple leaves. Leaves of the ashleaf maple seedlings (Acer negundo) were artificially damaged, and the blends of volatiles were detected with gas chromatography-mass spectrometry. As we will show here, some compounds that had been detected in insect-infested pla...

Shibota M.; Nagaoka A.; Shino A.; Fujita T., 1978: Renin angiotensin system in severe hypertension of stroke prone spontaneously hypertensive rats. Japanese Heart Journal 19(4): 655-656