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Supplementation of xanthophylls decreased proinflammatory and increased anti-inflammatory cytokines in hens and chicks

, : Supplementation of xanthophylls decreased proinflammatory and increased anti-inflammatory cytokines in hens and chicks. British Journal of Nutrition 108(10): 1746-1755

The present study investigated the effects of xanthophylls (containing 40 % of lutein and 60 % of zeaxanthin) on proinflammatory cytokine (IL-1β, IL-6, interferon (IFN)-γ and lipopolysaccharide-induced TNF-α factor (LITAF)) and anti-inflammatory cytokine (IL-4 and IL-10) expression of breeding hens and chicks. In Expt 1, a total of 432 hens were fed diets supplemented with 0 (as the control group), 20 or 40 mg/kg xanthophylls (six replicates per treatment). The liver, duodenum, jejunum and ileum were sampled at 35 d of the trial. The results showed that both levels of xanthophyll addition decreased IL-1β mRNA in the liver and jejunum, IL-6 mRNA in the liver, IFN-γ mRNA in the jejunum and LITAF mRNA in the liver compared to the control group. Expt 2 was a 2 × 2 factorial design. Male chicks hatched from 0 or 40 mg/kg xanthophyll diet of hens were fed a diet containing either 0 or 40 mg/kg xanthophylls. The liver, duodenum, jejunum and ileum were collected at 0, 7, 14 and 21 d after hatching. The results showed that in ovo xanthophylls decreased proinflammatory cytokine expression (IL-1β, IL-6, IFN-γ and LITAF) in the liver, duodenum, jejunum and ileum and increased anti-inflammatory cytokine expression (IL-4 and IL-10) in the liver, jejunum and ileum mainly at 0-7 d after hatching. In ovo effects gradually vanished and dietary effects began to work during 1-2 weeks after hatching. Dietary xanthophylls modulated proinflammatory cytokines (IL-1β, IL-6 and IFN-γ) in the liver, duodenum, jejunum and ileum and anti-inflammatory cytokine (IL-10) in the liver and jejunum mainly from 2 weeks onwards. In conclusion, xanthophylls could regulate proinflammatory and anti-inflammatory cytokine expression in different tissues of hens and chicks.


PMID: 22273061

DOI: 10.1017/S0007114512000025

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Ahmed, Z.U.; Hoque, M.M.; Rahman, A.S.; Sack, R.B., 1994: Thermal stability of an oral killed-cholera-whole-cell vaccine containing recombinant B-subunit of cholera toxin. An oral killed cholera vaccine containing 1 times 10-11 cells of Vibrio cholerae O1 (heat- or formalin-killed) representing the Ogawa and Inaba biotypes and containing 1 mg of B-subunit of cholera toxin (CTB) produced by recombinant DNA technology...

Hori M.; Guy R.H.; Maibach H.I., 1989: Mechanisms of action of skin penetration enhancers effect of polarity. Clinical Research 37(2): 725A

Cahier, S., 1964: Prevention of thrombo-embolic disease in oto-rhino-laryngology. Thrombo-embolic disease is not a common complication in this specialty, but 10 minor accidents and one sudden death occurred in over 1000 operations. Thromboelastograms are routinely done on these cancer patients with a tendency toward hypercoagul...

Briones, A.A., 1964: Mineralogical studies of some drained and reclaimed paddy soils. Diffraction patterns of sand and silt fractions showed an abundance of primary minerals, predominantly felspars and quartz. Magnetite or maghaemite and some hornblende, augite and olivine were present. The clay fraction was predominantly montmoril...

Smith, F.A.; Murray, F.J.; John, J.A.; Nitschke, K.D.; Kociba, R.J.; Schwetz, B.A., 1981: Three-generation reproduction study of rats ingesting 2,4,5-trichlorophenoxyacetic acid in the diet. Male and female 4- to 6-wk-old Sprague-Dawley rats (F0) were fed lab chow containing 2,4,5-trichlorophenoxyacetic acid to provide dosage levels of 0 (controls), 3, 10 or 30 mg per kg body weight per day for 90 days, and were then mated. At day 21...

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Tang, Y.; Zou, H.; Strong, J.A.; Cui, Y.; Xie, Q.; Zhao, G.; Jin, M.; Yu, L., 2006: Paradoxical effects of very low dose MK-801. Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. However, the MK-801 dose ranges commonly exa...

Anonymous, 1995: Expanded programme on immunization (EPI). Progress towards the global elimination of neonatal tetanus, 1989-1993. Releve Epidemiologique Hebdomadaire 70(12): 81-85

Albaret, J.-Louis.; Bayssade-Dufour, C.; Ngendahayo, L.D., 1993: Identification des cercaires de Schistosoma africains emises par Bulinus umbilicatus, B. truncatus et B. forskalii. Three chaetotaxic indices, AD, AL and U, of cercariae of four pre-identified African Schistosoma species, obtained from natural or experimental infections, were established. AD and AL correspond respectively to the relative distance between the do...