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Supraspinal modulation of trigeminal nociception and pain


, : Supraspinal modulation of trigeminal nociception and pain. Headache 49(5): 704-720

This study examined modulation of trigeminal pain/nociception by 2 supraspinal mechanisms: emotional controls of nociception and diffuse noxious inhibitory controls. Prior research suggests emotional picture viewing (emotional controls) and tonic noxious stimuli (diffuse noxious inhibitory controls) engage supraspinal mechanisms to modulate pain and nociceptive processes. It is currently unknown, however, whether emotional controls modulate trigeminal pain and nociception. Additionally, the influences of emotional controls and diffuse noxious inhibitory controls have not been compared in the same group of participants. Noxious electrodermal stimuli were delivered to the trigeminal nerve using a concentric electrode designed to selectively activate nociceptive fibers. Trigeminal nociception and pain were assessed (34 participants) from the nociceptive blink reflex and pain ratings, respectively. Emotional controls were engaged by presentation of standardized picture stimuli (pleasant, neutral, and unpleasant) shown to reliably evoke pleasure-induced inhibition and displeasure-induced facilitation of pain and nociception. Diffuse noxious inhibitory controls were engaged with a forearm ischemia task. Trigeminal pain (self-report ratings) and nociception (blinks) were facilitated by unpleasant pictures and inhibited by pleasant pictures. Emotion induction (as assessed from trend analysis) explained 51% of the variance in trigeminal pain and 25% of the variance in trigeminal nociception. Additionally, forearm ischemia inhibited trigeminal pain but not nociception. The baseline vs ischemia comparison explained 17% of the variance in pain report and 0.1% of the variance in blinks. Supraspinal modulation by emotional controls and diffuse noxious inhibitory controls were uncorrelated. Emotional controls and diffuse noxious inhibitory controls modulated trigeminal pain and emotional controls modulated trigeminal nociception. These procedures can be used to study supraspinal modulation of nociceptive processing in disorders of the trigeminal pain system, including headache.

US$19.90

PMID: 18783449

DOI: 10.1111/j.1526-4610.2008.01229.x


Other references

Brauer, R.O., 1959: A comparison of the tennison and Le Mesurier lip repairs. Plastic and Reconstructive Surgery and the Transplantation Bulletin 23(3): 249-259

Cholodkovsky, N., 1891: Zur Embryologie der Insecten. Relates to Graber's notes of the same title (342).

Fitzner, K.A.; Coughlin, S.; Tomori, C.; Bennett, C.L., 2000: Health care in Hong Kong and mainland China: one country, two systems?. Hong Kong and Mainland China are undertaking health reform following recent economic fluctuations and Hong Kong's transformation to a Special Administrative Region of China in 1997. Despite spending only 4.7% of its Gross Domestic Product on...

Hirapur, I.; Veeranna, R.; Agrawal, N., 2014: Regurgitation of blood flow from the ectatic LAD artery as a cause of angina demonstrated during coronary angiogram. Bmj Case Reports 2014: -

Turner, Keith., 1997: The little swift on the Isle of Wight. Birding World. May; 105: 182-183

Guzman, P.E. de, 1972: Studies on average sizes per serving of food items. The average sizes of portions and frequency of intakes of 73 food items in the diets of 506 men and 533 women Philippine government employees aged 21 to 39 years were studied by questionnaire. Little difference was noted between food items in the...

Magnusson, K.E.; Edebo, L., 1984: Carbohydrate exposure on salmonella and E. coli bacteria after reaction with antibody IgG and secretory IgA (SIgA) assessed with fluorescent lectins. The carbohydrate moieties exposed on enterobacteria before and after antibody binding have been tested with fluorescent lectins. Salmonella typhimurium 395 MS (S-type) and its Rd-mutant MR10 were coated with hyperimmune anti-MS and anti-MR 10 IgG,...

Zhang, F.T.; Li, Y.R.; Wu, Z.H., 1988: Discharge changes of various medullary respiratory neurons during reflexive apnea. Most medullary inspiratory neurons and phrenic nerve ceased firing, while the majority of expiratory neurons fired continuously during the period of apnea induced by intracarotid sinus injection of sodium citrate and during the lengthened expirato...

Edwards, L.; Friedrich, E.G., 1988: Desquamative vaginitis: lichen planus in disguise. A principal cause of desquamative vaginitis is erosive lichen planus. We report five cases to illustrate the classic oral and vaginal findings, describe the histology, and relate the therapeutic response of the disease. Early recognition of the di...

Baginsky, R.G.; Palmer, J.D.; Freed, M.M., 1971: Deprivation effects on the final common path in upper motor neuron lesions. Scandinavian Journal of Rehabilitation Medicine 3(3): 117-120