geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Surgical target selection in cerebral glioma surgery: linking methionine (MET) PET image fusion and neuronavigation


, : Surgical target selection in cerebral glioma surgery: linking methionine (MET) PET image fusion and neuronavigation. Minimally Invasive Neurosurgery 50(5): 273-280

The objective of this study was to investigate the histological correlate of (11)C-methionine (MET) PET uptake of brain gliomas by image fusion for navigated surgery. Twenty-seven patients (18 male, 9 female; mean age 42 years; range 11-77 years; 8 low-grade and 11 high-grade astrocytomas or mixed gliomas, 8 oligodendrogliomas) underwent MET PET studies preoperatively. MET PET tumor uptake was detected in 26 of 27 patients (96.3%). The quantitative MET tumor standardized uptake value (SUV) ratio was significantly higher in malignant gliomas and oligodendrogliomas than in low-grade gliomas (2.76/2.62 vs. 1.67, p=0.03). Generally, qualitative visual grading of MET uptake revealed 2 main patterns: focal MET uptake in 12 and uniform global MET uptake in 11 patients. Focal uptake corresponded to malignant glioma histology in 66.7%, and uniform global uptake to oligodendroglial histology in 72.7%. In oligodendrogliomas, global MET uptake constituted 81.5% (range 53.8-135%) of the MRI T(1) tumor volume on average and was limited to the MRI FLAIR tumor volume in 86% (7/8) of patients. Tissue samples of focal MET uptake areas correlated with histological anaplasia in 66.6% (8/12 glioma patients), although 62.5% (5/8 patients) lacked MRI contrast enhancement. MET PET image fusion may facilitate the targeting of anaplastic foci in homogeneous MRI non-enhancing gliomas for biopsy, may identify oligodendroglial histology preoperatively as well as characterize biologically active tumor volumes within MRI T(1)/FLAIR tumor areas of candidate patients for resection.

US$19.90

PMID: 18058643

DOI: 10.1055/s-2007-991143


Other references

Casabianca, D.; De-Donatis, M.; Mazzoli, S.; Wezel, F.-Carlo, 1995: The Colbordolo-Pesaro area of the Romagna-Marche foothill zone (northern Apennines, Italy). A detailed field survey, including structural and biostratigraphic analyses, has been integrated with sub-surface (seismic lines and well logs) data in order to reconstruct the stratigraphy, structure and tectonic evolution of the Colbordolo-Pesar...

Hausmann, D.; Wahl, G.H.; Nadstawek, J., 1989: Analgosedation as an adjuvant during surgery under local anesthesia. Twelve systemically healthy patients each (ASA risk groups 1-2) who required oral surgery under local anesthesia received the short-acting benzodiazepin Midazolam for analgosedation as well as the analgesics Pentazocin or Piritramid. Both i.v. med...

Romansky, M.J.; Dugan, D.J.; Rittman, G.E., 1945: Penicillin In Iodized Oil For Instillation Into The Lungs. (1) A suspension of calcium penicillin in 40 per cent. iodized oil produces a stable mixture which has been instilled in the lungs of 12 patients without adverse effect and has maintained penicillin in the lung for a minimum of 24 hours, after a s...

Hatcher, V.B.; Wertheim, M.S.; Rhee, C.Y.; Tsien, G.; Burk, P.G., 1976: Relationship between cell surface protease activity and doubling time in various normal and transformed cells. A sensitive method for measuring cell surface and secreted protease activity utilizing 3H-labeled casein is described. The method is based on proteolytic degradation of the casein substrate into trichloroacetic acid soluble 3H-labeled peptides. Ut...

Giraldo,E.; Martin-Cordero,L.; Garcia,J.J.; Gerhmann,M.; Multhoff,G.; Ortega,E., 2010: Exercise-induced extracellular 72 kDa heat shock protein stimulates neutrophil phagocytic and fungicidal capacities via TLR-2. This study evaluated the role of toll like receptor 2 (TLR-2) in the interaction of 72 kDa extracellular heat shock protein (Hsp72, a stress-inducible protein) with neutrophils and the participation on TLR-2 in the stimulation of neutrophil phagoc...

Sohrabi, S.; Wang, S.; Tan, J.; Xu, J.; Yang, J.; Liu, Y., 2016: Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature. NlmCategory="UNASSIGNED">Quantitative understanding of nanoparticles delivery in a complex vascular networks is very challenging because it involves interplay of transport, hydrodynamic force, and multivalent interactions across diffe...

Madhulika Singh; Uma Jaiswal; Jaiswal, V.S., 2003: In vitro selection of NaCl-tolerant callus lines and regeneration of plantlets in a bamboo (Dendrocalamus strictus Nees.). Sodium chloride-tolerant plantlets of Dendrocalamus strictus were regenerated successfully from NaCl-tolerant embryogenic callus via somatic embryogenesis. The selection of embryogenic callus tolerant to 100 mM NaCl was made by exposing the callus...

de Camargo, B.; Pereira de Carvalho Filho, Nçolino.; Lopes Pinto, C.Antonio.; Werneck da Cunha, I.; de Pinho, M.Lucia., 2003: Cryptococcosis mimicking a pulmonary metastasis in a child with Wilms tumor. The patient was a 6-year-old boy from Sao Paulo, Brazil with Wilms tumour stage IV (lung, liver lesions), who was first treated postoperatively with dactinomycin, vincristine and doxorubicin [date not given]. Seven months after cessation of therap...

Lip, G.Y.U., 2012: Bleeding risk assessment and management in atrial fibrillation patients. European Heart Journal 33(2): 147-149

Pomerleau, P.O., 1994: Performing GLP studies in a traditionally non-GLP facility. Situations can arise in which traditionally non-GLP facilities may have to be used for performing nonclinical GLP studies or parts of a GLP study. The situations may include a need for particular expertise of scientists, the analytical laboratory,...