geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer


, : Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. British Journal of Surgery 95(8): 1029-1036

Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population. All 68,308 citizens in Göteborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60-64 years. All were screened two to three times with rehydrated Hemoccult-II. Compliance was 70.0 per cent (23,916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer. After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0.84 (95 per cent confidence interval 0.71 to 0.99). The groups did not differ in incidence of colorectal cancer or in overall mortality. FOBT screening significantly reduces colorectal cancer mortality.

US$19.90

PMID: 18563785

DOI: 10.1002/bjs.6136


Other references

Forteza, R.Malbran.; Casalino-Matsuda, S.Marina.; Falcon, N.S.; Valencia Gattas, M.; Monzon, M.E., 2013: Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin. Cigarette smoke (CigS) exposure is associated with increased bronchial epithelial permeability and impaired barrier function. Primary cultures of normal human bronchial epithelial cells exposed to CigS exhibit decreased E-cadherin expression and r...

Lin, S.; Chen, C., 1986: Combining ability of major agronomic characters in maize (Zea mays L.). Journal of the Agricultural Association of China: (136) 6-14

Singer, Z.; Salwa, J., 1973: Delayed-type hypersensitivity and immunoglobulin levels in the course of chemotherapy of advanced malignant neoplasms. Archivum Immunologiae et Therapiae Experimentalis 21(2): 239-247

Salem, A.; Oueslati, H.; Guesmi, F.; Dziri, C.; Mnif, N., 2012: Digestive incarceration post celioscopy. La Tunisie Medicale 89(6): 588-592

Grober; Drew, 1991: Evidence for an electron-hole plasma in the photoluminescence spectra of insulating InSb at very low pump intensities. Physical Review. B, Condensed Matter 43(14): 11732-11739

Fomina T.N., 1974: Nitrogen metabolism indices in patients with viral hepatitis against the background of their medication with l glutamine and other drugs. Sovetskaya Meditsina 4: 89-93

Grant, W.C.; Fahrenbach, M.J., 1959: Effect of dietary sucrose and glucose on plasma cholesterol in chicks and rabbits. Chicks were fed purified diets containing 3% cholesterol and either casein, gelatin and sucrose or soybean protein and glucose together with vitamins and minerals. The chicks receiving casein, gelatin and sucrose had higher plasma cholesterol valu...

Zhao, C-Qi.; Xu, X-Chen.; Li, R-Yun.; Chen, J.; Yang, F-Lin., 2013: Highly effective permeability and antifouling performances of polypropylene non-woven fabric membranes modified with graphene oxide by inkjet printing and immersion coating methods. In the current study, graphene oxide (GO)-modified polypropylene non-woven fabric (PP-NWF) membranes were prepared via inkjet printing and immersion coating methods. Scanning electron microscopy, Fourier transform infrared spectroscopy, contact an...

Opinion 552., 1959: Grant under the Plenary Powers of precedence to the family-group name Globigerinidae Carpenter, Parker& Jones, 1862, over the family-group name Orbulinidae Schultze, 1854 (Class Rhizopoda, Order Foraminifera) and matters incid. Opinions rendered by the International Commission on Zoological Nomenclature, 20: 211-224

Zhang YongZhuo; Luo ZhengRong, 2004: Cryopreservation of dormant shoot tips of non-astringent types of Chinese persimmon by encapsulation-vitrification and plantlets regeneration. Shoot tips excised from dormant axillary buds of non-astringent types (5 cultivars) of Chinese persimmon (Diospyros kaki), which is originated from China, had been cryopreserved by encapsulation-vitrification for the first time. In the experiment,...