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Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer

, : Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. British Journal of Surgery 95(8): 1029-1036

Early detection of colorectal cancer could reduce cancer-specific mortality. The aim of this trial was to evaluate the effect of faecal occult blood test (FOBT) screening on colorectal cancer mortality in a Swedish population. All 68,308 citizens in Göteborg born between 1918 and 1931 were randomized to a screening or a control group at the age of 60-64 years. All were screened two to three times with rehydrated Hemoccult-II. Compliance was 70.0 per cent (23,916 individuals). Those with a positive test result were offered sigmoidoscopy and a double-contrast enema. The primary endpoint was death from colorectal cancer. After a mean of 9 years from the last screening, there was a significant reduction in colorectal cancer mortality in the screening group compared with the control group. The overall risk ratio of death from colorectal cancer was 0.84 (95 per cent confidence interval 0.71 to 0.99). The groups did not differ in incidence of colorectal cancer or in overall mortality. FOBT screening significantly reduces colorectal cancer mortality.


PMID: 18563785

DOI: 10.1002/bjs.6136

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Forteza, R.Malbran.; Casalino-Matsuda, S.Marina.; Falcon, N.S.; Valencia Gattas, M.; Monzon, M.E., 2013: Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin. Cigarette smoke (CigS) exposure is associated with increased bronchial epithelial permeability and impaired barrier function. Primary cultures of normal human bronchial epithelial cells exposed to CigS exhibit decreased E-cadherin expression and r...

Lin, S.; Chen, C., 1986: Combining ability of major agronomic characters in maize (Zea mays L.). Journal of the Agricultural Association of China: (136) 6-14

Singer, Z.; Salwa, J., 1973: Delayed-type hypersensitivity and immunoglobulin levels in the course of chemotherapy of advanced malignant neoplasms. Archivum Immunologiae et Therapiae Experimentalis 21(2): 239-247

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