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Survival prediction of gastric cancer by a seven-microRNA signature

, : Survival prediction of gastric cancer by a seven-microRNA signature. Gut 59(5): 579-585

Several microarray studies have reported microRNA (miRNA) expression signatures that classify cancer patients into different prognostic groups. No study has evaluated the association between miRNA expression patterns and gastric cancer prognosis. In this study, we developed a seven-miRNA signature that is closely associated with survival of patients with gastric cancer. MiRNA expression profile was analysed by real-time RT-PCR in 100 gastric cancer patients, which were randomly assigned to either the training set or the testing set. Cox proportional hazard regression and risk-score analysis were used to identify a stage-independent set of seven-miRNA signature in the training set that could classify patients with significantly different prognosis. This miRNA signature was further validated by the testing set and an independent cohort 60 patients. We have identified a seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0.0009) and relapse-free survival (p=0.0005) of gastric cancer patients. Multivariate analysis shown that the risk signature was an independent predictor of overall survival (HR=3.046; 95% CI, 1.246 to 7.445, p=0.015) and relapse-free survival (HR=3.337; 95% CI, 1.298 to 8.580, p=0.012). Furthermore, the predictive value of this seven-miRNA signature was validated in the testing set of 50 patients and an independent set of 60 patients. Our seven-miRNA signature is closely associated with relapse-free and overall survival among patients with gastric cancer. The prognostic signature could be applicable to future decisions concerning treatment.


PMID: 19951901

DOI: 10.1136/gut.2008.175497

Other references

Nyhan, W.L., 1968: Clinical features of the Lesch-Nyhan syndrome. Introduction--clinical and genetic features. Federation Proceedings 27(4): 1027-1033

Marshall, I., 1981: Gear to handle muck and slurry. Power farming 60(9): 24-25

Smythies, J.R.; Benington, F.; Bradley, R.J.; Morin, R.D.; Romine, W.O.J., 1974: On the mechanism of interaction between histone IIB1 and DNA and histone IIB2 and DNA. A mechanism is suggested at the molecular level whereby histone IIB2 can act as a cross link between two, or possibly three, adjacent and parallel strands of the DNA double helix some 40 A apart. From model-building experiments it is suggested tha...

Izquierdo-Saona, A.; Gallo-Carrillo, Tía.; Bellido-Boza, L.; Herrera-Añazco, P.; Mezones-Holguin, E., 2015: Deficiencies in prescription and access to diet-based treatment of chronic kidney disease in hemodialysis: a glimpse into the context of inequity. Revista Peruana de Medicina Experimental Y Salud Publica 30(4): 714-715

Thiede A.; Petersen R.; Hamelmann H., 1983: Intestinal injuries. Langenbecks Archiv fuer Chirurgie 361: 213-220

Berntson, L.; Damgård, M.; Andersson-Gäre, B.; Herlin, T.; Nielsen, S.; Nordal, E.; Rygg, M.; Zak, M.; Fasth, A., 2008: HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis. Juvenile idiopathic arthritis (JIA) is a heterogeneous condition with very few clinical and laboratory signs that can help predict the course and severity of the disease in the individual patient. The cell-surface antigen HLA-B27 is well known to...

Daghestani, A.N., 1988: Changing perspectives in substance abuse and the physician's role. Illinois Medical Journal 173(4): 255-258

Lenhard, R.; Conwell, D.; Smith, H., 1965: Establishing A Preventive Medicine Clinic In A Public Health Service Hospital. Public Health Reports 80: 551-554

Orhan, I.O.; Ozgel, O.; Kabak, M., 2002: Bones of the neurocranium in red falcon (Buteo rufinus). The aim of this research was to observe the anatomical features of the neurocranial bones in red falcon and to provide a good background for further studies related to this topic. Bones of 5 adults (2 males and 3 females) were investigated in the...

Lehr, U., 1981: Physical activities in old age - motivations and barriers. Sport as geroprophylaxis, as the opportunity and chance to prevent certain risk factors, as well as sport or physical training as therapy, are both emphasized. Correlations between sport activities and psycho-physical well-being were - based on nu...