geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery


, : Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery. Biological & Pharmaceutical Bulletin 31(9): 1667-1672

A combination of purine and xanthine oxidase (XOD) dose-dependently elicited sustained contraction of porcine coronary arterial rings and resulted in increased concentrations of superoxide anions and hydrogen peroxide. These contractile responses appeared, with a delay, after the application of purine and XOD, used as a reactive oxygen species (ROS)-generating system. Coronary arteries precontracted with prostaglandin F(2alpha) failed to relax in response to substance P after exposing the arterial preparation to this ROS-generating system. The contractile response of the coronary artery to the ROS-generating system was almost completely inhibited by catalase (130 U/ml), and was partially inhibited by superoxide dismutase (60 U/ml), or mannitol (30 mM). A voltage-dependent L-type Ca(2+) channel antagonist, nicardipine, had no effect on contraction. Dysfunction of endothelial cells was completely prevented by catalase, but not by superoxide dismutase or mannitol. These results suggest that superoxide anions, hydrogen peroxide and hydroxyl radicals might be involved in eliciting sustained, delayed-onset coronary artery contraction, which is not related to L-type Ca(2+) channels. They also suggest that hydrogen peroxide might play a major role in endothelial dysfunction of the porcine coronary artery.

US$29.90

PMID: 18758057


Other references

Obidoa O.; Obonna E.E., 1981: Afla toxin inhibition of reversed electron transfer in rat liver mitochondria in vitro. Aflatoxins B1 (AFB 1) and G1 (AFG1) were evaluated for activity toward energy-linked reduction of endogenous nicotinamide nucleotides by succinate and vitamin K3 during anaerobic reversed electron transfer in isolated rat liver mitochondria. These...

Gage-White, L.; Mankekar, C., 1997: Furlow palatoplasty-double opposing z-plasty. Indian Journal of Otolaryngology and Head and Neck Surgery 49(4): 422-423

Ng, H.W.; Walley, T.J.; Tsao, Y.; Breckenridge, A.M., 1994: Lack of pharmacodynamic interactions between acute dose flosequinan and xamoterol. A pilot study in healthy subjects. The possible cardiovascular pharmacodynamic interactions at rest and during exercise of combining oral flosequinan (100 mg) with xamoterol (200 mg) was investigated in a four-way randomised double-blind placebo-controlled crossover trial in eight...

Warner Mont M., 1972: Geothermal resources of Idaho. Two Known Geothermal Resource Areas, potential for others.

Williams, B., 2016: The 2015 JCEHP Award for Excellence in Research. Journal of Continuing Education in the Health Professions 35(4): 247-248

Sherman, H.M., 1917: Medical Military Matters in California. California State Journal of Medicine 15(10): 423-423

Spooner, C.E.; Winters, W.D., 1967: Evoked responses during spontaneous and monoamine-induced states of wakefulness and sleep. Averaged auditory evoked responses obtained during spontaneous wakefulness and sleep were characterized and compared with responses obtained following the administration of various monoamines in the implanted chick. Responses evoked after the admi...

Mercer, L., 2013: Improving the rates of organ donation for transplantation. Organ donation is a complex and sensitive area. It is complicated by ethical, legal and social factors, as well as differing views about consent. Although organ donation rates have risen, there continues to be a significant gap between organ suppl...

Kayumov, T.Kh, 1996: Disturbances of surfactant of pulmonary system before and after cholecystectomy. Uzbekiston Tibbiet Zhurnali 0(1): 88-89, 115, 122

Ike, R.W., 1994: Arthroscopy in rheumatology: a tool in search of a job. Journal of Rheumatology 21(11): 1987-1989