geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage


, : Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. Journal of Neuroscience 30(48): 16343-16355

N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses.

US$19.90

PMID: 21123580

DOI: 10.1523/JNEUROSCI.1984-10.2010


Other references

Wiwanitkit, S.; Wiwanitkit, V., 2015: Shisha versus cigarette smoking and endothelial function. Anadolu Kardiyoloji Dergisi 14(4): 408-408

Roos, J.; Kelly, R.B., 1997: Identification of Drosophila p160, a brain specific protein that interacts with dynamin. FASEB Journal 11(9): A1062

Asahi, Y., 1963: Structure Of Menadione Bisulfite. Chemical & Pharmaceutical Bulletin 11: 813-814

Hauenschild, C.; Fischer, A., 1969: Platynereis dumerilii Mikroskopische Anatomie, Fortpflanzung, Entwicklung. Grosses Zoologisches Praktikum Heft 106 Stuttgart: 1969. Unknown

Matveeva, N.K.; Volkova, L.S.; Smirnova, L.K., 1980: alpha-Fetoprotein in the amniotic fluid of isoimmunized pregnant women. Akusherstvo i Ginekologiia: 21-23

Messina, A.; Villa, E.; Dalla Tomba, M.; Troise, G., 2016: Transcatheter and surgical sutureless prosthesis for open-heart mitro-aortic valve replacement. European Journal of Cardio-Thoracic Surgery 50(5): 997-997

Ewing D.J., 1991: The natural history of autonomic dysfunction. Rifkin, H , J A Colwell And S I Taylor (Ed ) International Congress Series, 1000 Diabetes ; 14th International Diabetes Federation Congress: Washington, D C , Usa, June 23-28, Xxix+1337p Elsevier Science Publishers B V : Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York, Usa) Illus Maps 283-285

Comas, D.; Calafell, F.; Bendukidze, N.; Fañanás, L.; Bertranpetit, J., 2000: Georgian and kurd mtDNA sequence analysis shows a lack of correlation between languages and female genetic lineages. Mitochondrial DNA sequences from Georgians and Kurds were analyzed in order to test the possible correlation between female lineages and languages in these two neighboring West Eurasian groups. Mitochondrial sequence pools in both populations are...

Yeoh, T.Yeng.; Scavonetto, F.; Weingarten, T.N.; Karnes, R.Jeffrey.; van Buskirk, C.M.; Hanson, A.C.; Schroeder, D.R.; Sprung, J., 2015: Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy. Allogeneic blood transfusion induces immunosuppression, and concern has been raised that it may increase propensity for cancer recurrence; however, these effects have not been confirmed. We examined the association of perioperative transfusion of...

Anonymous, 2002: Boosting Market Cow Value. Beef 38(12): , 16