geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis


, : Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis. Hypertension 55(2): 249-256

Syndecan-1 (Synd1) is a transmembrane heparan sulfate proteoglycan that functions as a coreceptor for various growth factors and modulates signal transduction. The present study investigated whether Synd1, by affecting growth factor signaling, may play a role in hypertension-induced cardiac fibrosis and dysfunction. Expression of Synd1 was increased significantly in mouse hearts with angiotensin II-induced hypertension, which was spatially related to cardiac fibrosis. Angiotensin II significantly impaired fractional shortening and induced cardiac fibrosis in wild-type mice, whereas these effects were blunted in Synd1-null mice. Angiotensin II significantly increased cardiac expression of connective tissue growth factor and collagen type I and III in wild-type mice, which was blunted in Synd1-null mice. These findings were confirmed in vitro, where angiotensin II induced the expression of both connective tissue growth factor and collagen I in fibroblasts. The absence of Synd1 in either Synd1-null fibroblasts, after knockdown of Synd1 by short hairpin RNA, or after inhibition of heparan sulfates by protamine attenuated this increase, which was associated with reduced phosphorylation of Smad2. In conclusion, loss of Synd1 reduces cardiac fibrosis and dysfunction during angiotensin II-induced hypertension.

US$19.90

PMID: 20048198

DOI: 10.1161/HYPERTENSIONAHA.109.137885


Other references

Han, B.; Davis, L.S., 2011: Density-based multifeature background subtraction with support vector machine. Background modeling and subtraction is a natural technique for object detection in videos captured by a static camera, and also a critical preprocessing step in various high-level computer vision applications. However, there have not been many stu...

Grigorieva Tamara (Grigoriyeva Tamara); Moroz Tatiana; Pal chik Nadezhda A.; Tolmachev Valerii (Tolmachev Valeriy); Zelentsov Evgenii (Zelentsov Yevgeniy), 1999: Crystal chemical peculiarities of biomineral formations; X-ray powder diffraction and infrared spectroscopy analysis. Journal of Conference Abstracts 4(1): 659

Cobbold, C.A.; Sherratt, J.A.; Maxwell, S.R.J., 2002: Lipoprotein oxidation and its significance for atherosclerosis: a mathematical approach. Atherosclerosis is a chronic disease which involves the build up of cholesterol and fatty deposits within the arterial wall. This results in the narrowing of the vessel lumen, which eventually restricts blood flow to vital organs such as the heart...

Bredt, W.; Kist, M.; Jacobs, E., 1981: Phagocytosis and complement action. THe interaction of pathogenic mycoplasmas with two components of the "nonspecific" defence system is influenced by the lack of a cell wall and perhaps the tight attachment to host cells. On mycoplasmas, complement can act directly on the...

Bose, C.L.; LaPine, T.R.; Jung, A.L., 1985: Neonatal back-transport. Cost-effectiveness. This study examines the cost-effectiveness of returning previously ill neonates to community hospitals after treatment in a tertiary center, a concept known as "back-transport." The authors compared the charges for medical care during co...

Coruzzi, Cesare, 1930: Cutaneous stimulation and blood pressure. Various means of cutaneous stimulation were used repeatedly on 3 subjects, by preference hypodermic injection of physiologic solution. Fall or rise of arterial pressure was observed according to the stimulated region, the most pronounced fall occu...

Rios, J.; Iriarte, E.; Garate, D.; Cearreta, A.; Iriarte, M.J.se, 2008: The Mendieta site Sopelana, Biscay Province, northern Spain; palaeoenvironment and formation processes of a lower Palaeolithic open-air archaeological deposit. A rescue archaeological excavation on the Mendieta area (Sopelana, Biscay province) has shown the presence of lithic industry within an original stratigraphic context of possible Lower Palaeolithic age. The materials containing the lithic industry...

Herrick, R.; Ross, E., 1985: Effects of low-intensity and intermittent light on the performance of laying hens in Hawaii. Research series Hawaii Agricultural Experiment Station Hitahr College of Tropical Agriculture and Human Resources: 85 (029)

Gheorghiu, I., 1938: Cage Epizootics of Cancer among Mice. On the basis of his observation of a high incidence of cancer among mice kept in the same cages, the author considers that the existence of cage epizootics of cancer is established and he accepts the views advanced many years ago by Borrel. The mi...

Vitiello, M.; D'Isanto, M.; Finamore, E.; Ciarcia, R.; Kampanaraki, A.; Galdiero, M., 2008: Role of mitogen-activated protein kinases in the iNOS production and cytokine secretion by Salmonella enterica serovar Typhimurium porins. The expression of inducible nitric oxide synthase (iNOS) is a critical factor in both physiological and pathological functions. The present Study examined the role of mitogen-activated protein kinases (MAPKs) in the regulation of iNOS and proinfl...