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Synergism of cytotoxicity between cis-diaminedichloro-platinum-(ii) and cis-diamine(1,1-cyclobutanedicarboxylate)-platinum-(ii)

, : Synergism of cytotoxicity between cis-diaminedichloro-platinum-(ii) and cis-diamine(1,1-cyclobutanedicarboxylate)-platinum-(ii). International Journal of Oncology 4(2): 329-333

In an attempts to increase the antitumor effect and to reduce normal tissue toxicity, the combined cytotoxic effect of cis-Diamminedichloroplatinum (II) (CDDP) and cis-diammine(1,1-cyclobutane dicarboxylate) platinum (II) (CBDCA) was investigated using HeLa and colon 26 cell lines and the combination index (CI). Cytotoxicity of the combination of CDDP and CBDCA on 27 surgically resected specimens of human gastric and colorectal adenocarcinomas was also evaluated using the in vitro succinate dehydrogenase inhibition (SDI) test. The CI values varied with the dose ratio examined (1:1-1:6) of CDDP and CBDCA, with findings that CI<1, synergy, was obtained at fraction affected (Fa)>0.75 for HeLa cells and at Fa<0.9 for colon 26 cells in cases of a dose ratio of 1:1 to 1:2. Of all 27 clinical human adenocarcinomas, the succinate dehydrogenase (SD) activity was significantly lower in cancer cells concomitantly exposed to both CDDP and CBDCA than in those exposed to either drug alone. These positive effects of a combination of two platinum analogues on human malignant tissues have heretofore not been reported, which would warrant the clinical application of this combination for human malignant tumors.


PMID: 21566928

Other references

Gimmler, H.D.mmig, B., 1980: The effect of divalent cations on the permeability of the chloroplast envelope and on photosynthesis. Developments in plant biology(4): 443-446

Samuels, A.J.; Gorevic, P., 1968: Evidence suggesting a retardation of denervation atrophy upon injection of trophic brain proteolipids. Life Sciences 7(22): 1169-1179

Gonzalez, N.; Kalinin, Y.V., 1984: Chemical control of the citrus rust mite Phyllocoptruta oleivora. In tests to control the eriophyid Phyllocoptruta oleivora on Valencia orange in Cuba in 1978, zineb, triazophos, pirimiphos-ethyl, chlorobenzilate and dicofol (all of which have proved effective against the mite in preliminary tests) were applied...

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Demin, V.N., 1960: On the problem of the level of intersection of the removed portion of intestine in cancer of the large intestine and rectum. Khirurgiia 36: 49-54

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Shirley David N.; Warren Paul H., 1985: Differentiation of the Palisades Sill. Abstracts with Programs - Geological Society of America 17(7): 716

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