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Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies

, : Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies. European Journal of Medicinal Chemistry 66: 314-323

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA.


PMID: 23811093

DOI: 10.1016/j.ejmech.2013.05.046

Other references

Harris C.M., 1991: Re examination of pentylenetetrazole ptz like effect of nicotine nic and its withdrawal. Society for Neuroscience Abstracts 17(1-2): 1251

Shaver G.R., 1981: Mineral nutrition and leaf longevity in an evergreen shrub ledum palustre ssp decumbens. Effects of variable mineral nutrient status on evergreen leaf longevity were investigated in a field fertilization experiment, and by comparison of plants from several sites. The species studied was L. palustre ssp. decumbens, with a normal leaf l...

Vazzana, K.M.; Yao, S.C.; Jung, M-Kyung.; Terzella, M.J., 2015: Perception-based effects of clinical exposure to osteopathic manipulative treatment on first- and second-year osteopathic medical students. Little research has been done regarding osteopathic medical students' clinical exposure to osteopathic manipulative treatment (OMT). Most existing research focuses on third- and fourth-year students. To determine the effects of clinical expos...

Sackellares, Rw, 1994: Using predictive models on mill modernization projects. Tappi journal 77(9): 45-48

Hamre, Ml, 1975: Egg research and promotion referendum. Poultry patter: 75, 13 (9)

Robinson, P.W.; Mickelbart, M.V.; Arpaia, M.L., 1994: Hass avocado phenology in California - preliminary results. Hortscience 29(5): 517

Wright R.C., 1967: Mycobacterium tuberculosis in pasteurized milk letter pasteurization effectiveness enz phosphatase test guinea pig inoculation. British Medical Journal 5544: 108

Singh, H.K., 1975: Genotypes of rootstock and scion determining differential responses of navy bean lines phaseolus vulgaris to iron induced manganese chlorosis. Grafts in various root/scion combinations were made to determine the possible sites controlling differential responses of chlorotic lines 50 and 80 and nonchlorotic lines 40 and 47 of P. vulgaris to Fe-induced Mn chlorosis. Established grafts were...

Dautović-Krkić, S.; Huskić, J.; Cengić, D.; Dizdarević, S.; Beslić, S.; Guska, S.; Mesihović, H.; Mulić, S., 2003: Praziquantel in the prevention of recurrence of human echinococcosis. In a five year long study efficiency of Praziquental in a prevention of human echinococcosis relapses was studied. Study was conducted in a period from October 1996 till October 2000, and it included patients with echinoccosis treated in Clinical...

Wenz, Jm, 1999: Update on the current Douglas-fir tussock moth outbreak in the southern Sierra Nevada. Proceedings annual Forest Vegetation Management Conference: 0th) 107-109