geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Systematic missing-at-random (SMAR) design and analysis for translational research studies


, : Systematic missing-at-random (SMAR) design and analysis for translational research studies. International Journal of Biostatistics 4(1): Article 15-Article 15

Translational research studies often involve a central study (e.g. clinical trial, cohort of patients, etc.) and multiple investigators who are each interested in addressing different research questions using the same patient population. However, it is often impossible for the investigators to include all patients in all of the ancillary translational research substudies that are part of the main study. This arises due to time and budgetary constraints and other logistical considerations. In this paper, we propose a prospective Systematic Missing-At-Random study design (SMAR) with planned partially missing covariates collected using a nested random sampling scheme that allows an integrated statistical analysis across all domains of data. We propose an algorithm for data analysis that incorporates the features of the design. We show that the SMAR design is computationally and statistically efficient as well as cost effective using simulation studies and a published data example. An extension to a two-stage prospective-retrospective design is discussed.

US$19.90

PMID: 20231908

DOI: 10.2202/1557-4679.1046


Other references

Sonde, L.; Bronge, L.; Kalimo, H.; Viitanen, M., 2001: Can the site of brain lesion predict improved motor function after low-TENS treatment on the post-stroke paretic arm?. Previous reports suggest that afferent stimulation improves arm motor function in patients suffering from stroke. The aim of this pilot study was to test the hypothesis that the brain lesion location determines the response to low-frequency (1.7 H...

Janzen, C.J.; van Deursen, F.; Shi, H.; Cross, G.A.M.; Matthews, K.R.; Ullu, E., 2006: Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei. An experiment was conducted to investigate whether ablation of Argonaute1 (AGO1) in bloodstream forms (BS) of Trypanosoma brucei was associated with changes in the levels of high molecular weight retrosposon transcripts and retrosposon-derived sma...

Abreu, R.; Lopes, A.Alexandre.; Sousa, A.S.P.; Pereira, S.; Castro, M.P., 2015: Force irradiation effects during upper limb diagonal exercises on contralateral muscle activation. The aim of this study was to explore the force irradiation effects of upper limb isometric diagonal exercises on shoulder muscle activities. Interactions among diagonal directions, contraction intensities (moderate and maximum) and sex were assess...

Seifer, C.M.; Kenny, R.A., 2001: Head-up tilt testing in children. Long-term gastrostomy tubes have a widely accepted role in providing nutritional support. Traditionally, they have been placed by surgeons and by endoscopists. In the last decade, radiologists have come to play a major role in the placement of gas...

Leader, A., 2000: New reproductive technologies: why are we limiting choices for infertile couples?. Cmaj 161(11): 1411-1412

Thomas, O.T., 1895: Description of a new Chinese Squirrel. AnnGenova: 242

Muralidharan, S.; Box, M.S.; Sedivy, E.L.; Wigge, P.A.; Weigel, D.; Rowan, B.A., 2015: Different mechanisms for Arabidopsis thaliana hybrid necrosis cases inferred from temperature responses. Temperature is a major determinant of plant growth, development and success. Understanding how plants respond to temperature is particularly relevant in a warming climate. Plant immune responses are often suppressed above species-specific critical...

Abell, M.R.; Littler, E.R., 1975: Benign metastasizing uterine leiomyoma. Multiple lymph nodal metastases. A case of histologically benign lymph nodal metastases from a uterine leiomyoma in a 27-year-old woman is reported. It is postulated that fragments of a leiomyoma, detached at the time of endometrial curettage, entered dilated lymphatic channels i...

A.Liker, J., 1934: Uber die Biologie der Herpotrichia nigra Hartig Zeitschr Pflanzenkrank. 3 problems are considered: host range, type of parasitism, and the conditions controlling the appearance of the fungus in nature. Cross inoculation exps. showed there is only 1 strain of the fungus, as all isolates could infect several genera of c...

Dantas, R.Venâncio.Fernandes.; Conde, M.Cristian.Muniz.; Sarmento, H.Ramalho.; Zanchi, C.Henrique.; Tarquinio, S.Beatriz.Chaves.; Ogliari, Fício.Aulo.; Demarco, Fávio.Fernando., 2013: Novel experimental cements for use on the dentin-pulp complex. This aim of this study was to evaluate the physicochemical and biological properties of novel experimental cements (Hybrid, Paste and Resin) based on synergistic combinations of existing materials, including pH, diametral tensile strength (DTS) an...