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Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate with a congenital diaphragmatic hernia


, : Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate with a congenital diaphragmatic hernia. Journal of Pediatric Surgery 46(2): E19-E21

We report the case of a 38-week gestational age neonate, with isolated congenital diaphragmatic hernia presenting with refractory persistent pulmonary hypertension, systemic hypotension, and hypoxemia, resistant to usual therapeutics. Arginine vasopressin is responsible for systemic vasoconstriction and decreases pulmonary hypertension. We theorized that terlipressin, its long-acting analogue, could have the same properties. We used terlipressin as rescue therapy after parental and local ethics committee acceptance. After a bolus of terlipressin 20 μg/kg and continuous infusion at a rate of 5 μg/kg per hour, blood oxygen saturation improved from 75% to 98%, oxygen requirements fell from fraction of inspired oxygen 100% to 40%, and mean arterial pressure rose from 28 to 46 mm Hg, allowing a decrease of vasopressor infusion. Terlipressin may be useful in the management of neonates with congenital diaphragmatic hernia and refractory pulmonary hypertension.

US$19.90

PMID: 21292065

DOI: 10.1016/j.jpedsurg.2010.10.006


Other references

Vanni, S., 1993: Terza cattura nei mari italiani di Stephanolepis diaspros Fraser-Brunner, 1940 (Osteichthyies, Plectognathi, Monacanthidae). Atti della Societa Toscana di Scienze Naturali Residente in Pisa Memorie Serie B. 1992( ); 99: 11-13

Ehrlich, P.R.; Ehrlich, A.H., 1991: The most overpopulated nation. A stable population in the US in 1943 would have resulted in just 135 million people today making the import of foreign oil unnecessary. A population exerts an impact on the environment based on 3 factors: the size of the population (P), the level...

Jason, L.A.; Taylor, R.R.; Carrico, A.W., 2001: A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue. One proposed hypothesis regarding the etiology of chronic fatigue syndrome (CFS) is that there is a subgroup of patients in which symptom onset is precipitated by a viral infection. If this is indeed true, then one would anticipate a greater incid...

Vovin R.Y., 1967: The importance of studying the structure and dynamics of delirium syndromes in schizophrenia for their treatment by neuroleptics. Anon Vtoroi Vserossiiskii S"ezd Nevropathologov I Psikhiatrov, (The Second All-Russian Session Of Neuropathologists And Psychiatrists, From Ref Zh 1968, No 7 54 483-484

Lloyd K.G.; Morselli P.L., 1987: Psychopharmacology of gabaergic drugs. Meltzer, H Y (Ed ) Psychopharmacology: The Third Generation Of Progress Xliii 1780p +++raven Press: New York, New York, Usa Illus 183-196

Lowe, M.J.; Salter, T.; Rakovic, S.; Terrar, D.A., 2002: Investigation of the role of sodium-calcium exchange in cardiac pacemaking in the guinea-pig sino-atrial node. Journal of Physiology (Cambridge) 544P: 55P, November

Curras Collazo, M.C.; Jin, J.; Pandika, J.; Olea, M.L.on, 2001: Vasopressin and oxytocin decrease potassium-stimulated glutamate release from the adult rat supraoptic nucleus. Oxytocin (OXT) and vasopressin (VP) decrease synaptic responses in magnocellular neuroendocrine cells, (MNCs) from the supraoptic nucleus (SON; Kombian et al, 1997). To test whether presynaptic glutamate release is modulated by these neuropeptides...

Zeman, M.; Kosutzky, J.; Uhrin, V., 1989: The effect of the antioestrogen clomiphene citrate on the sexual development and plasma testosterone concentration in cocks. Data were obtained on 40 White Leghorn (Shaver) adult cocks maintained on deep litter at 15-h light:9-h darkness. The cocks were each given clomiphene citrate orally in a dose of 25 or 50 mg, on 1 or 6 occasions. The administration of the antioest...

Martin, Np, 1978: Alfalfa varietal selection. Minnesota dairyman: ng 7 (1) 2

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