+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The Fourier transform infrared spectra of the key organs derived from Kidney (Shen)-yang deficiency syndrome mice

, : The Fourier transform infrared spectra of the key organs derived from Kidney (Shen)-yang deficiency syndrome mice. Chinese Journal of Integrative Medicine 20(11): 829-834

To explore an approach to rapidly and accurately identify the compounds as biomarkers of Chinese medicine (CM) syndromes. The Fourier transform infrared (FT-IR) spectrometry was applied to investigate the characteristic components of a mice model of Kidney (Shen)-yang deficiency syndrome (KDS), and the remedial effect of a typical CM formula Shenqi Pill (). Thirty-six females and 18 males of Balb/c mice were randomly divided into KDS, Shenqi or control group. The females and males of the same group freely were mated for 96 h, and the males were taken out and only the female mice were raised. Females of the KDS group were threatened by a ferocious cat every other day for 14 d. After delivery, the KDS, or gestational threatened, offspring were raised at standard condition for 11 weeks. Then 10 male offspring were randomly selected, anaesthetized and their representative organs, i.e. testes, kidneys, lungs and feet were collected, for the FT-IR scan. Mice of the Shenqi group were intragastric administered Shenqi Pill; while mice in the KDS and control groups were given the same volume of saline. The attenuated birth outcomes of the KDS group were displayed. The remarkable FT-IR differences of all organs between KDS mice and healthy control were mainly at 1,735-1,745 cm(-1) (indicating the increased levels of lipids) and at 1,640-1,647 cm(-1) and 1,539-1,544 cm(-1) (displaying the decreased proteins). No statistic FT-IR difference between Shenqi and control mice was observed. In accordance with major traits of KDS, prenatal stress extensively impaired the building up of proteins and resulting in the excessive lipid storage, and FT-IR could effectively identify the biomarkers of KDS.


PMID: 24338184

DOI: 10.1007/s11655-013-1542-3

Other references

Bawden, F.C., 1946: Viras diseases of plants. In this paper, based on three lectures delivered before the Royal Society of Arts, London, in November and December, 1945, the writer, after an introductory discussion of the meaning of the term ' virus', deals with the external symptoms...

Fujita, N.; Huang, W.; Lin, T-Han.; Groulx, J-Francois.; Jean, S.; Nguyen, J.; Kuchitsu, Y.; Koyama-Honda, I.; Mizushima, N.; Fukuda, M.; Kiger, A.A., 2017: Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts thr...

Puri, A.; Morris, S.J.; Jones, P.; Ryan, M.; Blumenthal, R., 1995: Transfer of human erythrocyte membrane components to CD4+ non-human cells confers HIV-1 fusion susceptibility to those cells. Molecular Biology of the Cell 6(SUPPL ): 181A

Yu, J.; Yang, H.; Fang, B.; Zhang, Z.; Wang, Y.; Dai, Y., 2017: mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways. Ischemic stroke is a devastating neurological disorder and one of the leading causes of death and serious disability in adults. Adult neural stem cell (NSC) replacement therapy is a promising treatment for both structural and functional neurologic...

Kushner, R.F., 2008: Anti-obesity drugs. Recent discoveries about the metabolic and genetic control systems that govern regulation of body weight and energy expenditure have afforded the opportunity to develop pharmacological agents that can be used as adjunctive treatments for patients...

Rojas Miranda, T.; Marban-Mendoza, N., 1999: Pasteuria penetrans adherence and parasitism in Meloidogyne incognita and Meloidogyne arabicida Pasteuria penetrans adherencia y parasitismo en Meloidogyne incognita y Meloidogyne arabicida. Plant parasitic nematodes are frequently managed with chemical pesticides which can contaminate agroecosystems. Natural antagonists of nematodes may provide an alternative to the use of pesticides for nematode management. The bacterium Pasteuria p...

Barr, P., 2013: Hoping for a recovery. Modern Healthcare 43(1): 30-31

Vigorito, J.W., 1973: Comparative study of some mandibular characteristics in class I and class II, division 1, malocclusion. Revista Da Faculdade de Odontologia Da Universidade de Sao Paulo 11(1): 75-82

Anonymous, 2011: Inhibition of verocytotoxigenicEscherichia coliby antimicrobial peptides caseicin A and B and the factors affecting their antimicrobial activities. The antimicrobial activities of caseicin A and B antimicrobial peptides (AMPs) were assessed against a selection of verocytotoxigenicEscherichia coli(VTEC) strains (n = 11), other bacterial pathogenic and spoilage bacteria (n = 7), using a model b...

Peterson, R.D.; Funkhouser, J.D.; Tuck-Muller, C.M.; Gatti, R.A., 1992: Cancer susceptibility in ataxia-telangiectasia. Ataxia-telangiectasia (A-T) is a syndrome that has an extremely high incidence of cancer. Patients with the disease are homozygous for a mutant gene, the A-T gene, located at 11q23. Of these individuals, 30-40% develop cancer. Of these cancers, 80...