geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis


, : The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Research 69(8): 3272-3277

Transmembrane-4-L-six-family-1 (TM4SF1) was originally described as a cancer cell protein. Here, we show that it is highly expressed in the vascular endothelium of human cancers and in a banded pattern in the filopodia of cultured endothelial cells (EC). TM4SF1 knockdown prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and rendered EC senescent. Integrin-alpha5 and integrin-beta1 subunits gave a similar staining pattern and interacted constitutively with TM4SF1, whereas integrin subunits often associated with angiogenesis (alphaV, beta3, beta5) interacted with TM4SF1 only after vascular endothelial growth factor (VEGF)-A or thrombin stimulation. TM4SF1 knockdown substantially inhibited maturation of VEGF-A(164)-induced angiogenesis. Thus, TM4SF1 is a key regulator of EC function in vitro and of pathologic angiogenesis in vivo and is potentially an attractive target for antiangiogenesis therapy.

US$19.90

PMID: 19351819

DOI: 10.1158/0008-5472.CAN-08-4886


Other references

Nectoux-Lannebere, M., 1995: Touching as the heart of nursing care. Revue de L'infirmiere: 37-42

Bassaganya-Riera, J.; Viladomiu, M.; Pedragosa, M.; D.S.mone, C.; Carbo, A.; Shaykhutdinov, R.; Jobin, C.; Arthur, J.C.; Corl, B.A.; Vogel, H.; Storr, M.; Hontecillas, R., 2012: Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important. Probiotic bacteria can produce immunoregulatory metabolit...

Means, J.H.; Lerman, J., 1935: Symptomatology of myxedema. Its relation to metabolic levels, time intervals and rations of thyroid. Interesting generalizations are made from 240 cases. The basal metabolism of myxoedemics is less variable than that of normal individuals. Fully developed symptoms are rare with B.M.R. values above - 30 per cent. Slight symptoms are found within t...

Tyler Roger; Laubach Stephen E.; Schultz Ela Daniel D.; Tremain Carol M., 1994: Variations in Cretaceous and Tertiary coal fracture patterns, Rocky Mountain foreland, Western United States. Abstracts with Programs - Geological Society of America 26(7): 209

Blackhurst D.W.; Maguire M.G.; Macular Photocoagulation Study Group, 1989: Reproducibility of refraction and visual acuity measurement under a standard protocol. The authors present results of a study in which certified visual acuity examiners in the Macular Photocoagulation Study Group, performed independent replicate refractions and visual acuity measurements on both eyes of patients whose visual acuitie...

Wolter, M.; Penzholz, H., 1962: Angiographic demonstration of an aneurysm in the upper third of the basilar artery. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 97: 808-809

Bogautdinov, S.S.; Prikhodko, I.I., 1975: Economic efficiency of using dried skim milk in food concentrates. Potential substitution of dried skim milk for dried beef in food concentrates is studied. 1 kg skim milk DM is equal to 3 kg beef. The existing recipes stipulate 12 g of proteins in 18 g dried beef concentrate; the equivalent for the dried skim mi...

Al-Omar, B.A.; Saeed, K.S., 1998: Factors influencing patients' utilization of primary health care providers in saudi arabia. To determine the factors that significantly discriminate between Ministry of Health (MOH) and private primary health care patients in Riyadh City, Saudi Arabia. Through a self-administered questionnaire, data were collected from 408 randomly selec...

Birkhed, D.; Kalfas, S.; Svensäter, G.; Edwardsson, S., 1985: Microbiological aspects of some caloric sugar substitutes. Several caloric sugar substitutes are available today, e.g. maltitol, Lycasin, sorbitol, xylitol, palatinit, sorbose, coupling sugar, palatinose, fructose and invert sugar. When evaluating the cariogenicity of these sugar substitutes from a bacter...

Hadjibabaie, M.; Rahimian, S.; Jahangard-Rafsanjani, Z.; Amini, M.; Alimoghaddam, K.; Iravani, M.; Ghavamzadeh, A.; Sadrai, S., 2011: Population pharmacokinetics of oral high-dose busulfan in adult patients undergoing hematopoietic stem cell transplantation. Many factors have been reported that contribute to the wide intra- and inter-patient variability of Busulfan (Bu) disposition. The purpose of this study was to develop a population pharmacokinetic model and to determine the covariates affecting th...