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The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers

, : The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers. Current Molecular Medicine 7(5): 479-489

Wnt/beta-catenin signaling is constitutively increased in several major classes of tumors arising from the urogenital tract. In this review we focus on this pathway mainly in Wilms tumors and prostate carcinomas, followed by a brief discussion of its potential role in other types of urological tumors. Molecular studies in these types of cancers have highlighted novel components upstream and downstream of this central oncogenic pathway. Beta-catenin gain-of-function mutations are strongly linked to WT1 loss-of-function mutations in syndromic Wilms tumors, and Wnt/beta-catenin signaling increases androgen receptor mRNA expression and blocks apoptosis in prostate cancers. Novel downstream target genes activated by Wnt/beta-catenin signaling are emerging from expression profiling in genetically defined classes of Wilms tumors, and similar analyses are expected to reveal additional downstream genes of this pathway specific to prostate cancers. The identities of these genes will likely suggest new targeted therapies for urological malignancies.


PMID: 17691963

Other references

Lovering T.G.; Lakin H.W.; McCarthy J.H., 1966: Tellurium and mercury in jasperoid samples. Ninety-three samples of jasperoid from 22 areas, including 14 mining districts, were analyzed for tellurium and mercury by new methods capable of detecting 0.1 ppm of tellurium (by precipitation of gold in H Cl) and 0.01 ppm of mercury (by atomic...

Kumar, V.; Binder, W.L.; Schotland, E.; Beutner, E.H.; Chorzelski, T.P., 1978: Coexistence of bullous pemphigoid and systemic lupus erythematosus. A vesiculobullous eruption with clinical and histological features of bullous pemphigoid developed in a 28 yr old women with proven systemic lupus erythematosus (SLE). Serum of this pateint contained elevated titers of antinuclear antibodies. Base...

Klevezal, GA., 1984: A method of studying the food storage and the consumption of the food stored by rodents in nature. Rodents Apodemus spp., Cricetulus migratorius, Clethrionomys rutocanus were given food containing tetracycline in the field. The microstructure of incisors was studied in the animals caught and the width of dentin daily layer was determined. The w...

Zlotnick, C.; Zerger, S., 2008: Survey findings on characteristics and health status of clients treated by the federally funded (US) Health Care for the Homeless Programs. For almost two decades, the US Health Care for the Homeless (HCH) Program has funded clinics across the country for homeless populations. Between October and December 2003, for the first time ever, a nationally representative sample of the almost...

Wang, Q.; Kachelmeier, A.; Steyger, P.S., 2010: Competitive antagonism of fluorescent gentamicin uptake in the cochlea. Aminoglycosides enter inner ear hair cells via apical endocytosis, or mechanoelectrical transduction channels, implying that, in vivo, aminoglycosides enter hair cells from endolymph prior to exerting their cytotoxic effect. If so, circulating ami...

Nancy Jane, Y.; Khanna Nehemiah, H.; Arputharaj, K., 2016: A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease. Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to collect these data. Since these sensors generate time stamped data, analyzing gait dis...

Kinoshita, S., 1986: Some noteworthy records of moths from Kii Peninsula of Honshu. 1. Japan Heterocerists' Journal, 146 No. 135

Makens, J., 1987: How others see us. Results of a study indicated that New Zealand had a problem of 'product positioning' in Europe. Many Europeans believe that Canada and New Zealand are similar destinations. Although New Zealand is perceived as very safe, perceptions of N...

Hawkins, K., 1981: Spiders in Friday Woods. Colchester and District Natural History Society and Field Club Annual Reports and Records, 1980: 23-24

Marco S.; Ron H.; Beyth M.; Matthews A., 1990: Preliminary results of paleomagnetic and magnetic mineral study of igneous rocks of Mount Timna. Annual Meeting - Israel Geological Society 1990: 55