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The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study


, : The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study. Gynecologic Oncology 117(1): 82-87

To retrospectively evaluate the diagnostic accuracy and clinical relevance of magnetic resonance imaging (MRI) in the management of primary and recurrent vulvar cancer and to examine the added value of contrast-enhanced MRI (CE-MRI). The research ethics committee waived informed consent for this study of 49 patients with vulvar cancer (36 primary and 13 recurrent) who underwent MRI before surgery at three major cancer centers from December 2003 to January 2008. CE-MRI was available for 31 patients (20 primary and 11 recurrent). MR images were retrospectively evaluated by three radiologists for tumor size and stage. Lymph nodes with a short axis >5 mm were measured and scored for contour, presence of necrosis, loss of fatty hilum, signal intensity relative to the vulvar lesion, and reader's diagnosis of lymph node metastasis. Scoring was repeated for CE-MRI. Histopathology constituted the reference standard. The size of the vulvar lesion was accurately characterized on MRI in 83% of patients. Accuracy in staging of primary vulvar cancers on unenhanced MRI was 69.4% (n=36). Adding CE-MRI increased lesion detection and raised staging accuracy from 75% to 85% (n=20). For groin lymph node metastasis prediction, the ratio of the short- to the long-axis diameter and the reader's diagnosis of lymph node metastasis yielded accuracy of 85% and 87%, respectively, in groin-by-groin analysis. MRI can be useful in accurately assessing the size of vulvar lesion and groin lymph node metastasis. CE-MRI may be of help in improving local staging.

US$19.90

PMID: 20092880

DOI: 10.1016/j.ygyno.2009.12.017


Other references

Kim, D.; Kim, N.Hee.; Kim, S.Hee., 2013: 34 GHz pulsed ENDOR characterization of the copper coordination of an amyloid β peptide relevant to Alzheimer's disease. Angewandte Chemie 52(4): 1139-1142

Harris, L.A.; Henson, T.J.; Combs, D.; Melton, R.E.; Steele, R.R.; Marsh, G.C., 1996: Imaging and microanalyses of mercury in flood plain soils of East Fork Poplar Creek. Electron probe microanalysis, scanning electron microscopy with energy dispersive spectrometry, optical microscopy, and x-ray diffractometry were used to locate, identify, and analyze Hg-bearing matter in the soils from the East Fork Poplar Creek...

Salzmann-Wandeler, I.; Salzmann, H.C., 1972: 1st experiences counting field hares with spot lights. An attempt was made to apply the spotlight roadside census method to the European hare (Lepus europaeus Pallas a 12-V hand spotlight was held out of a car, driving at a constant speed of 8-9 km/h. Twenty-one fully evaluated and 5 partially evaluat...

Dong, Y., 1988: The Integrated Family Planning Project in China. FP and health education: a successful combination. The Integrated Family Planning, Maternal-Child Health Care, and Parasite Control Project has been underway since 1983 in 6 pilot areas in China. The project is a result of collaboration among the China Family Planning Association, the Japanese Org...

Govind Sheo, 1987: Studies on optimum harvesting time of turmeric. In trials with the turmeric [Curcuma longa] cultivars G.L. Puram and Daghi, planted in early Apr., the crop was sampled at 15-day intervals between late July and late Dec. The optimum harvesting time was between mid- and late Dec. However, the cur...

Eche, S.; Mackraj, I.; Moodley, J., 2017: Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia. Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia. Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive pat...

Fisher, C.E.; Palm, W.H.; Press, E.M., 1969: The N-terminal sequence of a human gamma 1 chain of allotype Gm(a(-)f(+)). Febs Letters 5(1): 20-22

Geerling, J., 1966: Gaucher's disease without splenomegaly. A case report. Folia Medica Neerlandica 9(2): 43-48

Anonymous, 2015: Maternity care review's aims are set out in wake of furness report. Nursing Standard 1987) 29(28): 8-8

Scazziga B., 1985: Insulin sensitivity and clearance rate in graves disease. Acta Endocrinologica Supplementum70: 16