+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma

, : The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Annals of Oncology 18(11): 1817-1827

DNA repair enzymes repair some of the DNA damage associated with risk factors for renal cell carcinoma (RCC), including smoking. DNA repair gene polymorphisms modulate the repair capacity and might influence individual risk and progression of RCC. We examined associations between functional polymorphisms and risk, clinicopathologic characteristics and survival of RCC. The study groups comprised 215 RCC patients and 215 age- and gender-matched healthy controls. Polymorphisms in xeroderma pigmentosum complementation groups C, D and G and X-ray repair cross-complementing groups 1 and 3 genes were genotyped. No significant differences in DNA repair genotype were observed between RCC cases and controls. In all patients, however, greater numbers (> or =3) of total variant alleles in all DNA repair genes studied were associated with less frequent venous extension (P = 0.0079). In smokers, some genotypes were associated with characteristics of RCC (Ps < or = 0.0067) and smokers with greater numbers of total variant alleles had improved overall survival (P = 0.040). These results suggest that DNA repair gene polymorphisms may not influence RCC susceptibility, but that some of them may influence RCC progression, especially in smokers, possibly due to altered DNA repair capacity by these polymorphisms.


PMID: 17712032

DOI: 10.1093/annonc/mdm337

Other references

Anonymous, 1999: Is there still a place for endoscopy in the diagnosis and therapeutic management of vesico-renal reflux?. Progres en Urologie 8(5): 777-781

Strijbos, M.H.; Verhoef, C.; Gratama, J.W.; Sleijfer, S., 2009: On the origin of (CD105+) circulating endothelial cells. Cells designated by the CellSearch assay as circulating endothelial cells (CEC) (CD146 (+)/CD105 (+)/ CD45(-) nuclear cells) are thought to derive from damaged vasculature. As CD105 has been suggested to be expressed by endothelial cells from mali...

Sherman, M., 2011: Hepatocellular carcinoma: screening and staging. Active screening of patients at risk for HCC has led to the identification of early HCCs that are amenable to treatment with a high rate of cure. This requires high-quality ultrasound examinations at 6-month intervals. If widely applied, screening...

May T.W.; Dorn G.A.; Hall R.F.; Morrison H.F.; Coen S., 1979: Detection of low shear-rigidity zones using shear-wave sources. Abstracts - Society of Exploration Geophysicists International Meeting 49): 54-55

Bryksina L.E.; Konov A.V.; Podgorodnichenko V.K.; Mazurik V.K.; Poverennyi A.M., 1985: Free thymidine in blood serum of irradiated rats with different degrees of cell depletion of thymus and spleen. The levels of the postirradiation thymidinemia, with an equal degree of the proceeding cell depletion of lymphoid organ tissues caused by the administration of dexamethasone and exposure of rats to 3 Gy radiation, markedly varied. Three days after...

Brewer, G.J., 1999: Zinc therapy induction of intestinal metallothionein in Wilson's disease. American Journal of Gastroenterology 94(2): 301-302

Zhou, H-Yi.; Chen, S-Rui.; Chen, H.; Pan, H-Lin., 2010: Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. Opioids remain the mainstay of treatment for severe pain, but the associated hyperalgesia and tolerance are significant impediments to achieving adequate pain relief with opioids. Here we show that in the spinal cord, brief application of the mu-o...

Von Albertini, B.; Mishkin, G.; Lew, S.Q.; Velasquez, M.; Bosch, J.P., 1996: Long-term survival outcome with high-efficiency dialysis Effects of time , membrane and reuse. Journal of the American Society of Nephrology 7(9): 1468

Anonymous, 1975: Panel report. Internal parasites in cats. A series of short reports by individual authors on common parasites of cats in various States of the USA mentions Dipylidium caninum, Diphyllobothrium latum, Toxocara cati, Toxascaris leonina and Taenia.

Comini, L.R.; Morán Vieyra, F.Eduardo.; Mignone, R.A.; Páez, P.L.; Laura Mugas, M.; Konigheim, B.S.; Cabrera, Jé.L.; Núñez Montoya, S.C.; Borsarelli, C.D., 2016: Parietin: an efficient photo-screening pigment in vivo with good photosensitizing and photodynamic antibacterial effects in vitro. The photophysical, photoinduced pro-oxidant and antibacterial properties in vitro of the natural occurring parietin (PTN; 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone) were evaluated. PTN was extracted from the lichen identified as Teloschi...