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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential


, : The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. Journal of Neuroscience 29(41): 12787-12794

The beta-amyloid (Abeta) peptide is the major constituent of amyloid plaques in Alzheimer's disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating neurodegenerative disorder. The beta-secretase, beta-site amyloid precursor protein cleaving enzyme (BACE1; also called Asp2, memapsin 2), is the enzyme responsible for initiating Abeta generation. Thus, BACE is a prime drug target for the therapeutic inhibition of Abeta production in AD. Since its discovery 10 years ago, much has been learned about BACE. This review summarizes BACE properties, describes BACE translation dysregulation in AD, and discusses BACE physiological functions in sodium current, synaptic transmission, myelination, and schizophrenia. The therapeutic potential of BACE will also be considered. This is a summary of topics covered at a symposium held at the 39th annual meeting of the Society for Neuroscience and is not meant to be a comprehensive review of BACE.

US$19.90

PMID: 19828790

DOI: 10.1523/JNEUROSCI.3657-09.2009


Other references

L.Moli, S., 1957: Protein imbalance in visceral infantile leishmaniasis. The author studied 8 cases by electrophoresis. Changes in the [alpha]1, [alpha]2 and [beta]-globulin fractions were negligible; a marked reduction in the albumin fractions and a clear rise in the gamma-globulin fraction (41-62.5% elevated) was see...

Evdokimova, T.I.; Sal' nikova, G.R.; Pervova, N.E., 1973: Biological activity of the forest soils of the Zvenigorod biological station. Gives details of the numbers of micro-organisms, by horizons, in : (1) strongly podzolic soil under Piceetum hylocomiosum; (2) swardy strongly podzolic soil under Birch; (3) swardy podzolic soil under Spruce/Birch; and (4) brown forest soil under...

Selvaggi, S.M.; Guidos, B.J., 2001: Immature teratoma of the ovary on fluid cytology. A case of an immature teratoma of the ovary in the peritoneal fluid of a 10-yr-old girl who presented with a pelvic mass is presented and discussed. The ThinPrep(R) preparation showed a few tight clusters of small tumor cells with a high nuclear/c...

Boccaccio, C.; Apiou, F.; Deschatrette, J.; Aurias, A.; Meunier-Rotival, M., 1994: Chromosomal localization and sequence analysis of a human episomal sequence with in vitro differentiating activity. The genomic fragment carrying the human activator of liver function, previously described as an episome capable of inducing differentiation upon transfection into a dedifferentiated rat hepatoma cell line, was mapped on human chromosome 12q24.2-12...

Barlow, C.A.; Sahmel, J.; Paustenbach, D.J.; Henshaw, J.L., 2017: History of knowledge and evolution of occupational health and regulatory aspects of asbestos exposure science: 1900-1975. The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbest...

Wheeler John, 1992: Stress as a fundamental control on metamorphic reactions. International Geological Congress, Abstracts--Congres Geologique Internationale, Resumes 29: 595

Lagerholm, S.; Harsten, G.; Emgård, P.; Olsson, B., 1999: Laser-turbinectomy: long-term results. Hypertrophy of the inferior turbinates is a common cause of nasal obstruction. Many cases respond to medical treatment with topical steroids or antihistamines. In some patients, however, this therapy is not sufficient and through the years many su...

Kreis, H.; Frese, K.; Wilmes, G., 1967: Physiological and histological changes in rats fed benzoic acid. The toxicity of benzoic acid has been investigated in weanling male rats. At a 3% dietary level for 5 days, growth was retarded and neurological disorders were manifested by irritation, ataxia and tonic-clonic convulsions. Brain damage was demonst...

Campbell, D., 1980: The unit value system: if you're not interested you should be. This paper, based on an address delivered at the 1977 C.A.O.T. Conference in Halifax, contends that, generally speaking, occupational therapists are neither well informed about, nor proficient in the use of statistics. This is unfortunate in an ag...

Sabolinski, M.; Falanga, V.; Giovino, K.; Toole, T., 2001: Mean healing rates at 4 weeks can predict complete wound closure of diabetic foot ulcers. Journal of Investigative Dermatology 117(2): 544, August