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The cecal appendix: one more immune component with a function disturbed by post-industrial culture

, : The cecal appendix: one more immune component with a function disturbed by post-industrial culture. Anatomical Record 294(4): 567-579

This review assesses the current state of knowledge regarding the cecal appendix, its apparent function, and its evolution. The association of the cecal appendix with substantial amounts of immune tissue has long been taken as an indicator that the appendix may have some immune function. Recently, an improved understanding of the interactions between the normal gut flora and the immune system has led to the identification of the appendix as an apparent safe-house for normal gut bacteria. Further, a variety of observations related to the evolution and morphology of the appendix, including the identification of the structure as a "recurrent trait" in some clades, the presence of appendix-like structures in monotremes and some non-mammalian species, and consistent features of the cecal appendix such as its narrow diameter, provide direct support for an important function of the appendix. This bacterial safe-house, which is likely important in the event of diarrheal illness, is presumably of minimal importance to humans living with abundant nutritional resources, modern medicine and modern hygiene practices that include clean drinking water. Consistent with this idea, epidemiologic studies demonstrate that diarrheal illness is indeed a major source of selection pressure in developing countries but not in developed countries, whereas appendicitis shows the opposite trend, being associated with modern hygiene and medicine. The cecal appendix may thus be viewed as a part of the immune system that, like those immune compartments that cause allergy, is vital to life in a "natural" environment, but which is poorly suited to post-industrialized societies.


PMID: 21370495

DOI: 10.1002/ar.21357

Other references

Spader, T.B.; Venturini, T.P.; Rossato, L.; Denardi, L.B.; Cavalheiro, P.B.; Botton, S.A.; Santurio, J.M.; Alves, S.Hartz., 2013: Synergysm of voriconazole or itraconazole with other antifungal agents against species of Fusarium. Infections caused by Fusarium are difficult to treat because these fungi show in vitro and in vivo resistance to practically all the antifungal agents available, which explains the high mortality rates. An attempt to overcome fungal resistance is...

Markman, G.S.; Urintsev, A.L., 1980: Theory of dissipative structures arising in the Turing-Prigozhin model. Biofizika 25(1): 148-152

Anonymous, 2012: The role of stellar mass and environment for cluster blue fraction, AGN fraction and star formation indicators from a targeted analysis of Abell 169. We present an analysis of the galaxy population of the intermediate X-ray luminosity galaxy cluster, Abell 1691, from Sloan Digital Sky Survey (SDSS) and Galaxy Zoo data to elucidate the relationships between environment and galaxy stellar mass fo...

Grinih, L.I., 1970: The influence of temperature on the activity of ethyl methane-sulphonate in Crepis capillaris. Roots of seedlings from seeds stored for 14 months had 0.6-0.8% chromatid aberrations and 0.7-0.8% chromosome aberrations compared with 0.2% and 0.03% in those from seeds stored for 2 1/2 months. Both lots of seeds were subjected to different comb...

Fraser, D.J., 2014: Evolutionary hypotheses for a constraint to life-history resilience in depleted Salmo salar populations. Phenotypic plasticity underlies much of the variation in life-history expression in fishes. An understanding of potential constraints on life-history plasticity thus may be critical for assessing the resiliency of populations or species to environ...

Virag, J., 1963: Method of testing for tolerance of yellows virus and results obtained hitherto. Of 193 sugar-beet varieties and strains tested since 1959, 28 showed mild symptoms and were classed as tolerant. Selection of the best plants from these populations, on the basis of visual evaluations and serological tests, led to considerable imp...

Streissguth A.P.; Barr H.M.; Martin D.C., 1982: Offspring effects and complications of labor and delivery related to self reported maternal alcohol use during pregnancy. Developmental Pharmacology & Therapeutics 4(SUPPL 1): 215-216

Liston, AD., 1984: Sawflies (Hymenoptera) collected in tent window traps at Delemont, Canton Jura, Switzerland. Mitteilungen der Entomologischen Gesellschaft Basel, 341: 6-24

Bourdeau, P., 1988: Aspects of host-parasite relationships in leishmaniasis and their consequences. The immunological aspects of Leishmania infections in man and animals are reviewed with emphasis on immunopathology and immunodepression. The consequences of these phenomena are discussed.

Frigerio, N.A.; Cheng, F.Y.; Marchi, M.L.; Rhoads, H.S., 1969: Dosimetry of small 252Cf sources in a human phantom. ANL-7635. Anl: 146-148