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The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer

, : The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer. Anticancer Research 30(5): 1689-1694

Cancer cell growth has been described to depend on glucose utilization. Activation of Akt and up-regulation of pyruvate kinase M2 (M2-PK) are attributes of tumour glycolysis. In order to evaluate the prognostic relevance of glycolytic markers in breast cancer, the expression of pAkt and M2PK was analysed in 160 tissue samples. The staining results were compared with clinicopathological characteristics and survival data. Overexpression of pAkt was detected in 58% and of M2PK in 70% of breast cancer samples. Increased pAkt-expression was accompanied with shorter survival time. In contrast, M2PK expression was significantly higher in patients surviving breast cancer for more than 13 years. Strong M2PK expression seems to be a favourable prognostic factor and its role in breast cancer progression should be further explored. Our data confirm previous observations of pAkt as a negative prognostic marker.


PMID: 20592362

Other references

Billingham, J.L.; Gennery, A.; Robinson, J.H.; Spickett, G.P.; Cant, A., 1997: Immunological studies on children with the 22q11 deletion syndrome. Immunology 92(SUPPL 1): 34, Dec

Y.H.iPeng; Liu YiXing; Zhang Bin; L.Y.ngFeng, 2004: Application of spatial gray level cooccurrence matrix in wood surface texture quantitative analysis. This paper introduces the spatial gray level co-occurrence matrix (GLCM) into wood surface texture quantitative analysis. Based on the data from 50 species, it is concluded that d equals to 3, and theta equals to 0 degrees in radial texture, equal...

Knowles, S.E.; Ballard, F.J.; Livesey, G.; Williams, K.E., 1981: Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs. 1. The effects of leupeptin and other microbial proteinase inhibitors were measured in rat yolk sacs on the uptake and degradation of formaldehyde-denatured 125I-labelled bovine serum albumin as well as on the degradation of 3H-labelled endogenous...

Gourreau, J.M.; Chermette, R., 1986: Bovine tinea. Pathogens, epidemiology of tinea due to Trichophyton verrucosum, symptomatology and lesional aspects, pathogenesis, diagnosis, treatment, prophylaxis and zoonotic aspects are discussed.

Mathew O.P.; Bland H.E.; Pickens J.M.; James E.J.P., 1979: Hypo glycorrhachia in the survivors of neo natal intra cranial hemorrhage. Survivors (15) of intracranial hemorrhage were studied to determine the incidence of hypoglycorrhachia. All infants developed hypoglycorrhachia 1 to several days after the hemorrhage. It persisted for a variable period before returning to normal....

Santoro, M., L.; Sousa, E.S.lva, M., C.C.; Goncalves, L., R.C.; Almeida-Santos, S., M.; Cardoso, D., F.; Laporta-Ferreira, I., L.; Saiki, M.; Peres, C., A.; Sano-Martins, I., S., 1999: Comparison of the biological activities in venoms from three subspecies of the South American rattlesnake (Crotalus durissus terrificus, C. durissus cascavella and C. durissus collilineatus). The subspecies of the South American rattlesnake, Crotalus durissus, are classified according to their external morphological features and geographical distribution. We have determined some biological activities of C. durissus cascavella, C. duris...

Kirmse, J., 2009: The nurse's role in administration of intravenous immunoglobulin therapy. Intravenous immunoglobulin is a valuable therapeutic agent for many patients with primary immune deficiency disorders and for some with secondary immunodeficiency, and its use has expanded to other areas such as neurologic, hematologic, and infect...

Downs-Kelly, E.; Nayeemuddin, K.M.; Albarracin, C.; Wu, Y.; Hunt, K.K.; Gilcrease, M.Z., 2008: Matrix-producing carcinoma of the breast: an aggressive subtype of metaplastic carcinoma. Matrix-producing carcinoma (MPC) of the breast is a subtype of metaplastic carcinoma defined as an invasive breast carcinoma with a direct transition of carcinoma to cartilaginous or osseous matrix without an intervening spindle cell component. Ou...

Stuart P.; Waltenbaugh C.; Melvold R., 1982: New intra i region recombinant in the mouse h 2 complex. Federation Proceedings 41(3): ABSTRACT 2009

Ali, A.; Abou-Ghadir, M.; Salman, A.; El-Sayed, A.; Mannaa, S., 1983: Evaluation of insecticides and time of their application for control of the red and black scale insects on orange trees in Assiut, Upper Egypt. Bulletin of the Entomological Society of Egypt Economic series: (11) 173-180