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The development of neutralizing human antibodies against rabies virus


, : The development of neutralizing human antibodies against rabies virus. Bing du Xue Bao 26(4): 271-275

A combinatorial human Fab library to the rabies virus was constructed using antibody genes derived from the blood of vaccinated donors. The library were panned and selected on purified rabies virus particles of aG or CTN strain with phage display. Eleven unique human Fab antibodies specific for the rabies virus glycoprotein were obtained by ELISA, IFA and DNA sequences analysis of these antibodies. Among these Fab antibodies, five human Fab antibodies were converted to full-length human IgG antibodies with recombinant baculovirus system. The five full-length human IgG antibodies were tested in vitro for rabies virus neutralization, resulting in all specificities to neutralize the virus. The obtained human anti-rabies antibodies lay the basis for the production of cocktail of anti-rabies monoclonal antibody with chinese intellectual property.

US$29.90

PMID: 20836379


Other references

Frank, Hm, 1986: Macrochemical color reactions of Macromycetes. II. Chemical properties and systematic position of Bondarzewia mesenterica. Mycotaxon 27(27): 503-506

Vaskivuo, T.E.; Anttonen, M.; Herva, R.; Billig, H.; Dorland, M.; T.V.lde, E.R.; Stenback, F.; Heikinheimo, M.; Tapanainen, J.S., 2001: Survival of human ovarian follicles from fetal to adult life: Apoptosis, apoptosis-related proteins, and transcription factor GATA-4. The majority of oocytes present in fetal ovaries are depleted before birth, and only about 400 will ovulate during the normal fertile life span. Studies on animals have shown that apoptosis is the mechanism behind oocyte depletion and follicular a...

Boellstorff, D.; Benito, G., 2005: Impacts of set-aside policy on the risk of soil erosion in central Spain. The 1992 European Union's Common Agricultural Policy (CAP) set-aside program led to an increase in area of set-aside land after 1992, but had a varying effect on soil erosion rates because of the different climatic, environmental and economic...

Alenazi, S.A.; Koura, H.M.; Zaki, S.M.; Mohamed, A.H., 2015: Prevalence of Obesity Among Male Adolescents in Arar Saudi Arabia: Future Risk of Cardiovascular Disease. Obesity in adolescence is crucial as it represents an important stage in human life. Dietary habits are greatly associated with lifestyle. Many reports suggested direct relationship between adolescent fatness and increased risk of cardiovascular d...

Port, N.L.; Lee, D.; Dassonville, P.; Georgopoulos, A.P., 1998: Manual interception of moving targets. I. Performance and movement initiation. We investigated the capacities of human subjects to intercept moving targets in a two-dimensional (2D) space. Subjects were instructed to intercept moving targets on a computer screen using a cursor controlled by an articulated 2D manipulandum. A...

Ando, M.; Yonemori, K.; Yunokawa, M.; Nakano, E.; Kouno, T.; Shimizu, C.; Katsumata, N.; Tamura, K.; Arioka, H.; Fujiwara, Y., 2016: Phase II study of carboplatin (CBDCA) and irinotecan (CPT-11) for patients with cancer of unknown primary (CUP). NlmCategory="UNASSIGNED">13514 Background: Optimal chemotherapeutic-regimen for CUP without favorable prognostic- factors is uncertain. Platinum containing regimens are widely used for those patients. To evaluate the efficacy and toxi...

Gavasheli A.M., 1978: Inclusions in ores of the Filizchay deposits. Transactions (Doklady) of the US

Paramo, T.; East, A.; Garzón, D.; Ulmschneider, M.B.; Bond, P.J., 2014: Efficient Characterization of Protein Cavities within Molecular Simulation Trajectories: trj_cavity. Protein cavities and tunnels are critical in determining phenomena such as ligand binding, molecular transport, and enzyme catalysis. Molecular dynamics (MD) simulations enable the exploration of the flexibility and conformational plasticity of pr...

Bleumink-Pluym, N.M.; Verschoor, F.; Gaastra, W.; van der Zeijst, B.A.; Fry, B.N., 1999: A novel approach for the construction of a Campylobacter mutant library. Given the lack of functional transposons for use in Campylobacter spp., an alternative method of insertional mutagenesis using natural transformation was developed. High efficiencies of transformation were only obtained with species-specific DNA....

Becker, W., 1973: Activation and inactivation of the miracidia of Schistosoma mansoni within the egg-shell. The activation of Schistosoma mansoni miracidia within the egg-shell takes place in 5 stages which can be observed microscopically: (i) flame beat in the protonephridia; (ii) contractions of the whole animal; (iii) movement of the cilia at the ant...