+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The different effects of over-expressing murine NMDA receptor 2B subunit in the forebrain on conditioned taste aversion

, : The different effects of over-expressing murine NMDA receptor 2B subunit in the forebrain on conditioned taste aversion. Brain Research 1351: 165-171

The glutamate transmission system and the N-methyl-D-aspartate receptor (NMDA-R), in particular its 2B subunit (NR2B), have been reported to be possibly related to taste memory as a result of treatment with NMDA antagonists and agonists. In order to further study the role of the NR2B subunit in gustation memory, we applied four different taste aversive tasks to observe the behavior of a transgenic mice model in which the NR2B subunit was specifically over-expressed in the forebrain. We found that in both short- and long-term conditioned taste aversion (CTA) experiments, mice with forebrain expression of the NR2B transgene (Tg) showed significantly enhanced CTA 2 days after training. However, both the Tg and the wild-type (Wt) mice shared the same level of aversive memory on the 30th day after training. In both fast and slow extinction experiments, Tg mice maintained a higher CTA memory than that of control mice in most extinction trials. The third experiment, which involved testing the memory for familiar taste, demonstrated that NR2B augmentation had no benefit on the latent inhibition (LI) of CTA. In addition, the last experiment (two-taste LI) showed a suppression of enhanced CTA in Tg mice when the mice were exposed to both novel and familiar tastes. These data suggested that forebrain NR2B over-expression had different effects on gustatory learning and memory. The transgenic animals were only sensitive to novel but not familiar tastes, and up-regulation of NR2B resulted in enhanced CTA function for only a short period of time.


PMID: 20537986

DOI: 10.1016/j.brainres.2010.06.004

Other references

Moesz, G., 1921: Mycological communications. Fourth communication. In this paper several new species are described, and figures and notes given on various fungi, chiefly Deuteromycetes and smuts. Phomopsis daucicola Moesz n. sp., on dead carrot-stems, is stated to be probably the conidial stage of Diaporthe denig...

Chiang, T., 1969: The physiology of flowering in Bamboo. Discusses gregarious and spontaneous flowering, periodicity of flowering, the effects of insects, diseases and climate, and a theory of nutrition.

Hand, R., 1976: Thymidine metabolism and DNA synthesis in Newcastle disease virus-infected cells. The inhibition of thymidine incorporation into DNA in Newcastle disease virus-infected cells has been studied. At 6 h after infection of L-929 cells at high multiplicity, transport of exogenous thymidine across the cell membrane was inhibited. The...

Scherf, M.; Klingenhoff, A.; Frech, K.; Quandt, K.; Schneider, R.; Grote, K.; Frisch, M.; Gailus-Durner, V.; Seidel, A.; Brack-Werner, R.; Werner, T., 2001: First pass annotation of promoters on human chromosome 22. The publication of the first almost complete sequence of a human chromosome (chromosome 22) is a major milestone in human genomics. Together with the sequence, an excellent annotation of genes was published which certainly will serve as an informa...

Krockenberger, M.B.; Canfield, P.J.; Malik, R., 2003: Cryptococcus neoformans var. gattii in the koala (Phascolarctos cinereus): a review of 43 cases of cryptococcosis. Details of 11 previously reported cases and 32 new cases of cryptococcosis in captive and wild koalas were analysed. Cryptococcus neoformans var. gattii accounted for all 29 cases in which varietal status was determined. No age or sex predispositi...

Allen G.A., 1983: The hybrid origin of aster bernardinus asteraceae. American Journal of Botany 70(5 PART 2): 104

Lacotte B.; Themelin D.; Ledoux A., 1987: Launois bensaude disease a review of two cases. Journal de Chirurgie 124(12): 684-689

Dobryszycka, W.; Woyton, J., 1966: Mucoprotelns, sialic acid and haptoglobin In normal and pathologic pregnancies. Total protein, mucoprotelns, sialic acid and haptoglobin were determined in venous and cord blood sera as well as in amniotic fluids from women who delivered in term and after prolongec pregnancy. In the group of women who delivered In term, the f...

Chan, A.; de Seze, Jérôme.; Comabella, M., 2016: Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis. Teriflunomide is a once-daily oral agent that has been licensed in the EU since August 2013 for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS). More recently (September 2014), the EU summary of product character...

Hendrixson, B.E., 2001: A new species of Vaejovis (Scorpiones, Vaejovidae) from Sonora, Mexico. Vaejovis pequeno, a new species of scorpion previously confused with V. waueri Gertsch & Soleglad 1972, is described and illustrated from Sonora, Mexico and is compared to that species. A revised diagnosis and new distributional records for V. wau...