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The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis


, : The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis. American Journal of Kidney Diseases 52(3): 454-463

Pentoxifylline is a potential therapeutic agent for diabetic kidney disease because it has anti-inflammatory, antifibrotic, and hemorheological properties. Systematic review and meta-analysis of randomized controlled trials. Adult patients with diabetic kidney disease who received oral pentoxifylline. We searched bibliographic databases for trials involving pentoxifylline that reported proteinuria, glomerular filtration rate, or blood pressure. The primary outcome measure was the effect of pentoxifylline on proteinuria stratified by whether pentoxifylline was compared with renin-angiotensin system blockade. 10 studies including a total of 476 participants with a median duration of 6 months were identified. Pentoxifylline significantly decreased proteinuria (weighted mean difference, -278 mg/d of protein; 95% confidence interval [CI], -398 to -159; P < 0.001) compared with placebo or usual care. Compared with captopril, the decrease in proteinuria with pentoxifylline was similar (weighted mean difference, 0 mg/d of protein; 95% CI, -17 to 18; P = 0.9). Secondary analysis showed that patients with microalbuminuria had a nonsignificant decrease in protein excretion (weighted mean difference, -87 mg/d; 95% CI, -201 to 27; P = 0.1), whereas those with overt proteinuria (protein > 300 mg/d) had a significant decrease (weighted mean difference, -502 mg/d; 95% CI, -805 to -198; P = 0.001). No significant changes in systolic or diastolic blood pressure or glomerular filtration rate were found. Quality scores of studies were low, and there was significant heterogeneity. Available evidence suggests that pentoxifylline may decrease proteinuria in patients with diabetic nephropathy. To confirm these findings, large high-quality studies are required.

US$19.90

PMID: 18433957

DOI: 10.1053/j.ajkd.2008.01.025


Other references

Alteras, I.; Cojocaru, I., 1970: Involvement of toe-nails by Candida. Although C. more frequently involves the finger nails, C. albicans was isolated in 23 of 450 (5%) toe-nail infections examined over 10 yr.

Kimura D.K.; Chikuni S., 1987: Mixtures of empirical distributions an iterative application of the age length key. It is well known that an age-length key is capable of providing biased estimates of age distributions, when length distributions are applied to age-length keys constructed from sampling in a different year from that in which the length data wre co...

Daido, Y., 1974: A plan for development of human resources in the aged--a trial at Takarazula-Shi. Nursing Technique 20(1): 111-117

Salvat, G.H.mbert, F.C.lin, P.L.hellec, C.B.nnejean, G., 1989: Protection of chickens against the infection of a Salmonella typhimurium strain with the aid of a barrier flora excempted from the specific pathogenic organisms of different ages. Avian pathology: journal of the WVPA8(2): 345-350

Genci, L.; Galik, R., 1974: Effect of supplements of lysine and monoethanolamine on digestibility and retention of nutrients in fattening pigs on increased amounts of extracted cottonseed meal. 1. 1. Groups of 6 young male pigs were given a diet of 97.28% cottonseed oilmeal, vitamins, minerals and trace elements with no supplement or with 0.60% lysine or 0.50% monoethanolamine. There was no significant difference between the groups in diges...

Bentwich, M.Ethel.; Dickman, N.; Oberman, A., 2016: Autonomy and dignity of patients with dementia: Perceptions of multicultural caretakers. A key message in the World Health Organization's report on dementia emphasizes the need to improve public and professional attitudes to dementia and its understanding, while acknowledging the fact that the workforce in dementia care is becomi...

Chassagne, J.F.; Corbel, S.; Gimenez, F.; Chassagne, S.; Gerard, H., 1999: Rapid prototyping and bone reconstruction. The authors describe the main techniques for rapid prototyping used in the medical field, with particular emphasis on Laser stereolithography. They describe the basics of the technique as well as the procedures they currently use to construct anat...

Anonymous, 1985: Papers of the 4th symposium on the prevention of blindness. Pulawy, 20-21 September 1984. Klinika Oczna 87(7): 269-311

Whitehouse, F.; Williams, P.; Kahkonen, D.; Nerenz, D., 1997: Differences between African-American and Caucasian patients in self-reported functional health status. Diabetologia 40(SUPPL 1): A638

Parameswaran, S.; Spaeth-Rublee, B.; Huynh, P.Trang.; Pincus, H.Alan., 2013: Comparison of national mental health quality assessment programs across the globe. This study by the International Initiative for Mental Health Leadership Clinical Leaders Project sought to describe ongoing or soon-to-be-established national-level mental health quality measurement programs in 12 participating countries, in order...