geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of risedronate (17.5 mg/week) treatment on quality of life in Japanese women with osteoporosis: a prospective observational study


, : The effect of risedronate (17.5 mg/week) treatment on quality of life in Japanese women with osteoporosis: a prospective observational study. Journal of Bone and Mineral Metabolism 30(6): 715-721

A prospective observational study to test the effects of risedronate 17.5 mg/week treatment on quality of life (QOL) of 1,363 Japanese female patients with osteoporosis showed QOL improvement after 12 weeks of administration. Comorbid factors such as ischemic heart disease, hip osteoarthritis, and higher values of FRAX blunted the effects of QOL of the treatment. Few studies have investigated the effect of osteoporosis treatment on QOL in relationship to comorbid factors other than osteoporosis and fracture. Efficacy was determined by changes over time in EQ-5D at baseline, at 12 and 24 weeks, and at the final assessment. Factors affecting changes in EQ-5D were evaluated with a multivariate analysis. Safety was determined by assessing the incident rate of adverse events. The improvement of EQ-5D compared to baseline was observed as significant after 12 weeks of treatment (p < 0.001). The greatest improvement was observed in the dimension of "pain/discomfort" by the multivariate analysis (p < 0.001). Factors affecting QOL improvement were FRAX value without BMD, age, glucocorticoid use, ischemic heart disease, hip osteoarthritis, and pain. The incidence rate of drug-related adverse events was 4.72 % (95 % confidence interval 3.63-6.02 %). Risedronate at 17.5 mg/week improved the QOL in patients with osteoporosis among Japanese women, and comorbidity factors decreased the effects.

US$19.90

PMID: 22868656

DOI: 10.1007/s00774-012-0372-2


Other references

Wehmiller J.F., 1990: Amino acid racemization applications in chemical taxonomy and chronostratigraphy of quaternary fossils. Carter, J G (Ed ) Skeletal Biomineralization: Patterns, Processes And Evolutionary Trends, Vol 1 Vii+832p Van Nostrand Reinhold: Florence, Kentucky, Usa; Chapman And Hall: London, England, Uk Illus Maps 583-608

Sakurai, J.; Egashira, T.; Yamada, Y.; Nomura, N., 1991: Lysis of middle-cerebral-artery occlusion with alteplase. Lancet 338(8776): 1206-1207

Bao, M.; Chen, Y.; Li, F.; Ma, J.; Lv, T.; Tang, Y.; Chen, L.; Xu, Z.; Wang, T., 2014: Plate-like p-n heterogeneous NiO/WO₃ nanocomposites for high performance room temperature NO₂ sensors. Plate-like heterogeneous NiO/WO₃ nanocomposites have been successfully prepared by annealing Ni(OH)₂ and H₂WO₄ in air. These NiO/WO₃ nanocomposites have shown excellent sensitivity towards NO₂ and ultrafast response at room temperature...

Heiss,C.J.; Naylor,J.; Bronco,K.M.; Myers,B.J., 2008: A small food or fluid load has no effect on body composition measured by 3 different methods. The purpose of this study was to determine whether there is a difference in percent body fat measured by hand-to-hand bioelectrical impedance analysis (BIA), dual-energy x-ray absorptiometry (DXA), and air displacement plethysmography (ADP) both b...

Claramita, M.; Susilo, A.Pratidina.; Kharismayekti, M.; van Dalen, J.; van der Vleuten, C., 2015: Introducing a partnership doctor-patient communication guide for teachers in the culturally hierarchical context of Indonesia. A guide for a partnership style of doctor-patient communication tailored to a Southeast Asian culture was previously developed and validated. We introduced the guide to clinical teachers in Indonesia through a participatory approach. Evaluation wa...

Lindfors, K.; Halttunen, T.; Huotari, P.; Nupponen, N.; Vihinen, M.; Visakorpi, T.; Maki, M.; Kainulainen, H., 2000: Identification of Ded, an evolutionary conserved novel putative transcription factor. JPGN 31(Supplement 3): S22, September

Clum, G.A., 1975: Intrapsychic variables and the patient's environment as factors in prognosis. Psychological Bulletin 82(3): 413-431

Susilo, R.; Moudrakovski, I.L.; Ripmeester, J.A.; Englezos, P., 2006: Hydrate kinetics study in the presence of nonaqueous liquid by nuclear magnetic resonance spectroscopy and imaging. The dynamics of methane hydrate growth and decomposition were studied by nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI). Three well-known large molecule guest substances (LMGS) were used as structure H hydrate formers: 2,2-dimethy...

Arbuzova, O.N.; Nikitin, V.P., 2003: On the taxonomy of tertiary Capparaceae. Cleome- and Cleomella-like fossil seeds from the Palaeogene and Neogene of Russia and adjacent states have been investigated using scanning electron microscope. The seeds resemble those of modern members of the subfamily Cleomoideae (Capparaceae)...

Mahnert, V., 1978: New species of pseudoscorpions (Arachnida, Pseudoscorpiones) from Greek caves. Annales Musei Goulandris: ) 273-298