geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis


, : The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis. Reproductive Biology and Endocrinology 12: 60-60

Ovulation has long been associated with an increased risk in ovarian cancer, yet the underlying molecular mechanisms remain obscure. Two aspects of ovulation have been linked to ovarian cancer pathogenesis. The first is the impact of repetitive tissue injury and repair that occurs with each ovulatory event. The second is the release of follicular fluid that accompanies the follicular rupture and its effect on the ovarian and fallopian tube epithelial cells. Hormones are an important component of follicular fluid, which transiently bathes the ovarian surface and fallopian tube epithelium during ovulation. Much work has been done exploring the role of hormones in fertility, but some, such as estrogen, have also been implicated in the pathogenesis of ovarian and other cancers. Understanding the role of hormones within follicular fluid, as well as how they are altered in disorders which increase ovarian cancer risk, will enhance our ability to assess risk and develop preventative strategies. This review provides an in depth discussion of the logistics of using and studying follicular fluid in ovarian cancer research, and discusses the fluctuations in follicular fluid hormone levels during normal physiological processes versus conditions that increase ovarian cancer risk.

US$19.90

PMID: 24997727

DOI: 10.1186/1477-7827-12-60


Other references

Sayasith, K.; Dore, M.; Sirois, J., 2007: Molecular characterization of tumor necrosis (Sa(B-induced protein 6 and its human chorionic gonadotropin-dependent induction in theca and mural granulosa cells of equine preovulatory follicles. The preovulatory rise in gonadotropins causes an expansion of the cumulus-oocyte complex, a process requiring the induction of several genes. The objectives of this study were to clone the equine tumor necrosis factor (Sa(B-induced protein 6 (TNFA...

Tavernier, P.; Portais, J.; Nava, S.; Courtois, J.; Courtois, B.; Barbotin, J., 1997: Exopolysaccharide and Poly-(beta)-Hydroxybutyrate Coproduction in Two Rhizobium meliloti Strains. The effects of different nitrogen and carbon sources on cell growth, pH, and exopolysaccharide (EPS) and poly-(beta)-hydroxybutyrate (PHB) production by two strains of Rhizobium meliloti (M5N1 and Su47) are reported. Differences in the behavior of...

Zheng, F.; Xie, W., 2017: High-sensitivity C-reactive protein and cognitive decline: the English Longitudinal Study of Ageing. High-sensitivity C-reactive protein (hs-CRP) has been suggested to be involved in the process of cognitive decline. However, the results from previous studies exploring the relationship between hs-CRP concentration and cognitive decline are incons...

Peters, W.A., 1978: Canine systemic lupus erythematosis. Journal of the South African Veterinary Association 49(3): 227-227

Chen, Q.; Liu, Z.; Wang, B.; Wang, X.; Lai, J.; Tian, F., 2016: Transcriptome sequencing reveals the roles of transcription factors in modulating genotype by nitrogen interaction in maize. Global transcriptome analysis in maize revealed differential nitrogen response between genotypes and implicate a crucial role of transcription factors in driving genotype by nitrogen interactions at gene expression level. Developing nitrogen-effic...

Adelman, L.S.; Young, E.; Bass, N.H., 1974: Abnormal accumulation of sialoglycoproteins in a case of late infantile amaurotic idiocy. Neurology 24(11): 1045-1050

Kiec, W.; Knapik, J.; Roborzynski, M.; Krupinski, J.; Sikora, J., 1994: Application of the EUROP grading system in carcass evaluation of Polish Blackheaded and Merino x Romanov (F1) ram lambs. Six Polish Blackheaded and 6 crossbred lambs were fattened intensively to approximately 40 kg live weight, and 6 lambs from each of the 2 breed groups were fattened semi-intensively to 28-80 kg. The carcasses were evaluated by the EUROP system of...

Lo, K.Y.; Kuzmin, A.; Unger, S.M.; Petersen, J.D.; Silverman, M.A., 2011: KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Dense-core vesicles (DCVs) are responsible for transporting, processing, and secreting neuropeptide cargos that mediate a wide range of biological processes, including neuronal development, survival, and learning and memory. DCVs are synthesized i...

Szczecińska, M., 1979: Acute and chronic leukemia. Wiadomosci Lekarskie 32(2): 81-100

Mathieu Gilbert, 1938: Note de geologie et de geographie physique sur la cote vendeenne entre la Pointe du Grouin-du-Cou et l'anse de l'Aiguillon. Note on the tectonics of the Oxfordian (Jurassic) of the coast of Vendee, France, between Grouin-du-Cou and Aiguillon bay, and recent shore-line changes.