geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The hypothalamic GnRH pulse generator: multiple regulatory mechanisms


, : The hypothalamic GnRH pulse generator: multiple regulatory mechanisms. Trends in Endocrinology and Metabolism: Tem 20(8): 402-408

Pulsatile secretion of gonadotropin-releasing hormone (GnRH) release is an intrinsic property of hypothalamic GnRH neurons. Pulse generation has been attributed to multiple specific mechanisms, including spontaneous electrical activity of GnRH neurons, calcium and cAMP signaling, a GnRH receptor autocrine regulatory component, a GnRH concentration-dependent switch in GnRH receptor (GnRH-R) coupling to specific G proteins, the expression of G protein-coupled receptors (GPCRs) and steroid receptors, and homologous and heterologous interactions between cell membrane receptors expressed in GnRH neurons. The coexistence of multiple regulatory mechanisms for pulsatile GnRH secretion provides a high degree of redundancy in maintaining this crucial component of the mammalian reproductive process. These studies provide insights into the basic cellular and molecular mechanisms involved in GnRH neuronal function.

US$19.90

PMID: 19740674

DOI: 10.1016/j.tem.2009.05.002


Other references

de Souza Braga, Francisco Manoel., 1999: The grade of feeding preference a qualitative and quantitative method for stomach content analysis O grau de preferencia alimentar um metodo qualitativo e quantitativo para o estudo do conteudo estomacal de peixes. Acta Scientiarum. June; 212: 291-295

Kagami, S-ichiro.; Owada, T.; Kanari, H.; Saito, Y.; Suto, A.; Ikeda, K.; Hirose, K.; Watanabe, N.; Iwamoto, I.; Nakajima, H., 2009: Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. Recent studies have suggested that statins, the inhibitors for 3-hydroxy-3-methyglutaryl (HMG)-CoA reductase in the mevalonate pathway, exhibit anti-inflammatory effects. However, the immune modulatory effects of statins on the differentiation of...

Schneider, Günter., 2007: Organ centers in oncology--exemplified by Aalen Ostalb Clinic: more responsibility in nursing. Pflege Zeitschrift 60(11): 611-613

Chen, R.M.o Yuan; Hung, T.L., 1995: Diurnal fluctuation of serum lipids in normal and hyperlipemic subjects. Clinical Chemistry 41(S6 PART 2): S144

Zhang, W.; Qin, L.; He, X-Wen.; Li, W-You.; Zhang, Y-Kui., 2009: Novel surface modified molecularly imprinted polymer using acryloyl-beta-cyclodextrin and acrylamide as monomers for selective recognition of lysozyme in aqueous solution. A novel protein imprinted polymer for selective recognition of lysozyme was obtained. Acryloyl-beta-cyclodextrin, which offered hydrophilic exterior and hydrophobic cavity that were allowed to self-assemble with the template protein through hydrog...

Anonymous, 1967: India. Water for the Villages. Pure water is now flowing in six Indian villages in the Ratnagiri district of Maharashtra State thanks to funds raised in Finland as part of the Freedom-from-Hunger Campaign. Previously the village wells were often completely dry, and many were co...

Murphy, D.A.; Marelich, W.D.; Hoffman, D., 2000: Assessment of anxiety and depression in young children: support for two separate constructs. Validated the interrelatedness of depression and anxiety in young children by testing four latent factor models: dual construct, unrelated; dual construct, correlated; single construct; and second-order or higher order analysis to test that depres...

Choi, Y-Hong.; Tathireddy, P.; Skliar, M., 2006: Method for measuring thickness of dielectric films using microdielectric fringe-effect sensors. A method for noninvasive thickness measurements of dielectric films using fringe-effect (FE) sensors is developed and experimentally validated. The fringing electrical field, created by electrodes microfabricated at the film substrate, depends on...

Zeitlhofer, J.; Mayr, N.; Auff, E., 1990: The value of evoked potentials in brain death diagnosis. At the moment evoked potentials in Austria are not admitted for diagnosing brain death. Brainstem auditory evoked potentials are proving the loss of the brainstem function, if a primary supratentorial lesion is excluded and if they disappear bilat...

Edwab, R.R.; Roberts, M.J.; Sole, M.S.; Rappaport, S.C., 1981: Skin grafts for denture construction on cancer patients after surgery. New York State Dental Journal 47(7): 385-387