geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The influence of calcitonin on the liver secretory function in rats


, : The influence of calcitonin on the liver secretory function in rats. Fiziolohichnyi Zhurnal 57(3): 40-48

The influence of calcitonin on the choleresis level and bile acids spectrum was investigated in acute experiments on the rats with common biliary duct cannulated. We determined the intensity of bile secretion during 3 hours and quantitative content of conjugated and free bile acids using thin-layer chromatography. It was shown that intramuscular introduction of synthetic salmon calcitonin (200 ng/kg) increases the secreted bile volume and the content of conjugated bile acids in the bile. The administration of salmon calcitonin resulted in increase of bile volume (+17.4% (P<0.05)), taurotrihydroxycholates (+58,3% (P<.001)), taurodihydroxycholates (+68.5% (P<0.01)), glycodihydroxycholates (+120.8% (P<0.01)), while the total content of free bile acids was not significantly altered as compared with control. At the same time, under the hormone influence we observed bile acid spectrum redistribution and a part of conjugated cholates increased against a decreasing of free bile acids part. The present results suggest that the salmon calcitonin intensifies the processes of conjugation of bile acids with amino acids taurine and glycine in hepatocytes and canalicular secretion that results in improvement of solubilization properties of the bile, ability of the bile to hold cholesterol in solute state and prevent the formation of calculi in biliary tracts.

US$29.90

PMID: 21870517


Other references

Wilton Derek H.C., 1990: Metallogeny of the Labrador Central Mineral Belt. Atlantic Geology 26(3): 291

Serafin M.; Vidal P.P.; D.W.ele C.; Khateb A.; Muhlethaler M., 1989: Burst firing of medial vestibular nuclei neurons in vitro. Society for Neuroscience Abstracts 15(1): 452

Leblondel, G.; Mauras, Y.; Allain, P., 1986: Tissue distribution of some elements in rats. The concentrations of 14 elements were determined in rat whole blood, plasma, brain, heart, skeletal muscle, liver, kidney, spleen, thymus, and bone, using multielement ICP optical emission spectrometry. The tissue to plasma concentration ratios w...

Bukstein, O.G., 2015: Attention deficit hyperactivity disorder and substance use disorders. During the past two decades, there has been an increased recognition that Attention Deficit Hyperactivity Disorder (ADHD) is overrepresented in treatment and community populations of both adolescents and adults with substance use disorders (SUDs)....

Zeff, R.H.; Pfeffer, R.B.; Adams, P.X.; Ruoff, M., 1976: Reoperation for amputation neuroma of the cystic duct. Two cases of amputation neuroma of the cystic duct are reported. In both instances, significant symptoms were totally relieved by excision of the neuroma. Review of the literature reveals at least twenty similar cases with the same results. Emphas...

Friedell, G.H.; Betts, A.; Sommers, S.C., 1965: The Prognostic Value Of Blood Vessel Invasion And Lymphocytic Infiltrates In Breast Carcinoma. Blood vessel invasion was found in 46% of 153 surgical specimens of breast carcinoma and was associated both with a significantly lower 5-year survival rate and with more deaths from cancer after 5 years postmastectomy. Women with neither vascular...

Koller O.; Haram K., 1984: The maternal hemo globin level and fetal risk a reevaluation. Tidsskrift for den Norske Laegeforening 104(9): 645-648, 681

Michiels, N.K.; Newman, L.J., 1998: Sex and violence in hermaphrodites. Hermaphrodite sexual behavior was investigated in the marine flatworm Pseudoceros bifurcus Prudhoe. Laboratory observations of 17 pairs of flatworms revealed that sexually interacting individuals rear up and evert their penis on contact. Escalated...

Kume,K.; Omari,I.; Tahiri,F., 2008: Albanian local cattle breed. The history of cattle farming in Albania started as early as 6000 BC, however, increasing demands for milk, meat and animal power initiated the government to buy imported breeds. In 1927, imported breeds were purchased majority of which belongs to...

Oda, I., 1968: Histochemical localization of ascorbic acid in the ciliary processes of rabbits. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift für Augenheilkunde 155(6): 464-475