+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The latest evidence in the neuroscience of solvent misuse: an article written for service providers

, : The latest evidence in the neuroscience of solvent misuse: an article written for service providers. Substance Use & Misuse 46 Suppl 1: 62-67

This work reviews preclinical and clinical studies published during the past two decades on the cellular and behavioral effects of commonly misused solvents. In animals, acute solvent exposure produces motor impairment and antidepressant- and anxiolytic-like effects. Human intoxication from misusing solvents is similar to that of ethanol; however, hallucinations and sudden sniffing death may occur at high solvent concentrations. Among chronic misusers, there is evidence of impaired memory, increased prevalence of psychiatric disorders, and neurological damage. Solvents facilitate inhibitory neurotransmission and block excitatory mechanisms. Toluene, in particular, increases brain dopamine levels and its effects occur at concentrations that do not dissolve cell membranes; therefore, neuronal damage is not an immediate, unavoidable consequence of solvent misuse.


PMID: 21609148

DOI: 10.3109/10826084.2011.580215

Other references

Scheifley, C.H., 1950: The current digitoxin controversy. Gp 2(1): 59-61

Fajklewicz Z.; Madej J., 1982: In situ study of tension wave fields by the microgravimetric method. Archiwum Gornictwa 27(3): 153-169

Chojnacki, J., C.; Machula, S.; Orlowski, A., 2007: Spatial and temporal variability of Copepoda in the pelagic zone of the Pomeranian Bay (2001-2003). This investigation of Pomeranian Bay waters was conducted from March 2001 to August of 2003 from aboard the r/v Nawigator XXI, which is owned by the Maritime Academy in Szczecin. A total of 147 water samples were collected at 15 stations on three...

Birceanu, O.; Servos, M.R.; Vijayan, M.M., 2015: Bisphenol A accumulation in eggs disrupts the endocrine regulation of growth in rainbow trout larvae. Bisphenol A (BPA), a monomer used in the production of plastics and epoxy resins, is ubiquitously present in the aquatic environment. BPA is considered a weak estrogen in fish, but the effects of this chemical on early developmental events are far...

Xu, B.Y.; Israelsen, P.; Pan, B.X.; Wang, D.; Jiang, X.; Varma, R., 2016: Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study. The purpose of this study was to evaluate the benefit of analyzing an increased number of anterior segment optical coherence tomography (AS-OCT) images on measurement values of various anterior segment parameters. Subjects for this cross-sectional...

Ranucci, M.; Isgro, G., 2007: Recombinant activated factor VII in cardiac surgery. Background and objective: Recombinant activated factor VII (rFVIIa) is a pharmacologic compound approved for the use in patients with congenital or acquired hemophilia and inhibiting antibodies toward factor VIII or IX. In recent years its use ha...

Ahlstrom, H.; Alvero, J.; Alvero, R.; Espos, R.; Fajutrao, L.; Herrera, J.; Kjellman, B.; Kubista, J.; Leviste, C.; Meyer, P.; Oldaeus, G.; Siricururat, A.; Vichyanond, P.; Wettrell, G.; Wong, E.; Laxmyr, L.; Nyberg, L.; Olsson, H.; Weibull, E.; Rosenborg, J., 2002: Pharmacokinetics of bambuterol during oral administration to asthmatic children. Aims: To investigate dose proportionality, dosing frequency, and ethnic aspects of the pharmacokinetics of bambuterol in asthmatic children, and to discuss the relationship with previous observations in adults. Methods: Forty-eight children in fou...

Sasaki, H.; Shitara, M.; Yokota, K.; Hikosaka, Y.; Moriyama, S.; Yano, M.; Fujii, Y., 2013: MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas. The expression of multidrug-resistant protein-3 (MRP3), a membrane-bound transporter, has been linked to drug resistance in non-small cell lung cancers (NSCLCs). Recently, we reported that NRF2 gene (NFE2L2) mutations are correlated with poor prog...

Phillips Patrick J.; Stinson Beverley; Esposito Kathleen; Furlong Edward T.; Gray James L.; Zaugg Steven D.; Kolpin Dana W., 2006: Concentrations and removal of organic wastewater compounds at a conventional activated sludge and pilot membrame bioreactor/ reverse osmosis facility. A conventional activated sludge wastewater treatment plant and pilot membrane bioreactor (MBR) wastewater plant with reverse osmosis (RO) and advanced oxidation processes (AOP) were sampled three times during August through October 2005 for over 7...

Dräger, N., 1977: Determatophilosis and demodicosis of cattle in the Chobe district (Northen Botswana). Berliner und Munchener Tierarztliche Wochenschrift 90(23): 454-457