+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression

, : The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression. Neuropharmacology 58(2): 321-329

Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron and bilirubin. Bilirubin is a potent antioxidant and neuroprotectant. Neurotrophic factors of BDNF and GDNF also play important roles in survival and morphological differentiation of dopaminergic neurons. We have previously found that HO-1 induction by adenovirus containing human HO-1 gene (Ad-HO-1) in substantia nigra of rat increases BDNF and GDNF expression. We here further examined the possible mechanism of HO-1 action involved in the enhancement of neurotrophic factor expression. Treatment of anti-BDNF/GDNF antibody significantly enhanced dopaminergic neuronal death, whereas Ad-HO-1 co-treatment was able to antagonize the apoptosis-inducing effect of these antibodies. The confocal imaging shows that HO-1 induction appeared in dopaminergic neuron, astrocyte and microglia at 24 h after injecting Ad-HO-1. HO-1 induced-BDNF/GDNF mRNA expression in substantia nigra was 26/21 folds of that of the contralateral Ad-injected side. The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures. In addition, bilirubin also enhanced BDNF expression through similar pathway in cortical neuron-enriched cultures. We also examined the effect of another HO-1 product, CO, by using CO donor. [Ru(CO)3Cl2]2 increased neurotrophic factor expression via sGC-PKG pathway in both neuron and glia. These results indicate that the downstream products of HO-1, i.e. bilirubin and CO, modulate BDNF and GDNF expression in neuron and astrocyte.


PMID: 19925812

DOI: 10.1016/j.neuropharm.2009.11.003

Other references

Sun, P.L.; Liu, J.N.; Cao, L.Q.; Yao, M.; Gao, H.W., 2017: To evaluate the clinicopathologic characteristics and outcome of tumor cells spreading through air spaces in patients with adenocarcinoma of lung. <b>目的:</b> 研究肿瘤细胞气腔内播散(spread through air spaces,STAS)与肺腺癌患者临床病理学特征、分子学特征以及患者预后之间的关系。 <b>方法:</b> 收集2010年1月至2014年1...

HuoKaiMing, 2008: Analysis of congenital African malaria cases. China Tropical Medicine: 3, 403

Slavkin, H.C., 2002: The 'mouth-body connection': is there one?. Fda Consumer 36(3): 36-36

MacPherson, D.W., 1999: Intestinal parasites in returned travelers. This article discusses epidemiological surveys and studies, clinical presentation and management of intestinal parasites (helminths and protozoa) in travellers.

Chen, M.; Carass, A.; Jog, A.; Lee, J.; Roy, S.; Prince, J.L., 2016: Cross contrast multi-channel image registration using image synthesis for MR brain images. NlmCategory="UNASSIGNED">Multi-modal deformable registration is important for many medical image analysis tasks such as atlas alignment, image fusion, and distortion correction. Whereas a conventional method would register images with...

Malhotra, R.S.; Robertson, L.D.; Saxena, M.C., 1995: Stability of performance of determinate faba bean (Vicia faba L.). The original determinate mutant of faba bean introduced from northern Europe is poorly adapted to the Mediterranean environment but efforts have been made to transfer the determinate trait into an otherwise desirable background. Twelve improved de...

Rossi, F.Nelli, A.; Cavallini, D.; D.M.Rco, C.; Trasatti, F., 1955: Fetal hemoglobin. I. Quantitative analysis of amino acids of crystallized human fetal hemoglobin and various technical devices. Bollettino Della Societa Italiana di Biologia Sperimentale 31(3-4): 328-330

Gramentz, Dieter., 2000: On the biology of Trionyx triunguis Forskal, 1775 in Gabon Zur Biologie von Trionyx triunguis Forskal, 1775 in Gabun. Sauria. Marz; 221: 19-24

James, K.; Mautone Smith, N., 2002: Trauma and substance abuse Implications for treatment providers. Drug & Alcohol Dependence 66(Supplement 1): S85, 1 May

Kaya, M.; Gacar, A.; Demirci, B.; Soylu, S.Mehmet.; Gulbahar, M.Yavuz., 2015: Atrioventricular Dissociation and Congestive Heart Failure in a Ring-Necked Pheasant ( Phasianus colchicus ). The aim of this clinical report was to describe a case of complete atrioventricular dissociation in a 9-month-old, male ring-necked pheasant ( Phasianus colchicus ). The case was incidentally determined during the evaluation of electrocardiograms...