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The natural history of insomnia: acute insomnia and first-onset depression

, : The natural history of insomnia: acute insomnia and first-onset depression. Sleep 37(1): 97-106

While many studies have examined the association between insomnia and depression, no studies have evaluated these associations (1) within a narrow time frame, (2) with specific reference to acute and chronic insomnia, and (3) using polysomnography. In the present study, the association between insomnia and first-onset depression was evaluated taking into account these considerations. A mixed-model inception design. Academic research laboratory. Fifty-four individuals (acute insomnia [n = 33], normal sleepers [n = 21]) with no reported history of a sleep disorder, chronic medical condition, or psychiatric illness. N/A. Participants were assessed at baseline (2 nights of polysomnography and psychometric measures of stress and mood) and insomnia and depression status were reassessed at 3 months. Individuals with acute insomnia exhibited more stress, poorer mood, worse subjective sleep continuity, increased N2 sleep, and decreased N3 sleep. Individuals who transitioned to chronic insomnia exhibited (at baseline) shorter REM latencies and reduced N3 sleep. Individuals who exhibited this pattern in the transition from acute to chronic insomnia were also more likely to develop first-onset depression (9.26%) as compared to those who remitted from insomnia (1.85%) or were normal sleepers (1.85%). The transition from acute to chronic insomnia is presaged by baseline differences in sleep architecture that have, in the past, been ascribed to Major Depression, either as heritable traits or as acquired traits from prior episodes of depression. The present findings suggest that the "sleep architecture stigmata" of depression may actually develop over the course transitioning from acute to chronic insomnia.


PMID: 24470699

DOI: 10.5665/sleep.3316

Other references

Baillaud L., 1971: Biological rhythms a botanists point of view concerning some problems in general biology. Experientia (basel): 489-501

Jacobs, A.M., 1965: Extraterrestrial "Geology": Finding the Right Words. Science 147(3654): 109-109

Abele, R.; Clavel, M.; Dodion, P.; Bruntsch, U.; Gundersen, S.; Smyth, J.; Renard, J.; van Glabbeke, M.; Pinedo, H.M., 1987: The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas. The Early Clinical Trials Cooperative Group of the EORTC conducted several phase II studies with a pyrimidine analogue of deoxycytidine, 5-aza-2'-deoxycytidine (DAC). The drug was given as three consecutive 1 h i.v. infusions of 75 mg/m2, sep...

Ehrnsperger, M.; Hergersberg, C.; Wienhues, U.; Nichtl, A.; Buchner, J., 1998: Stabilization of proteins and peptides in diagnostic immunological assays by the molecular chaperone Hsp25. Diagnostic assays for proteins devoid of enzymatic activity are becoming increasingly important. Antibodies generated against the respective proteins are used for their detection in enzyme-linked immunosorbent assay or patient sera are used to mon...

Bazylczuk, L., 1965: Rheumatological hospital in Heinoli (impressions from a trip). Reumatologia 3(3): 315-319

Saucier, D.M.; Kimura, D., 1998: Intrapersonal motor but not extrapersonal targeting skill is enhanced during the midluteal phase of the menstrual cycle. Verbal articulatory speed and small-amplitude manual skills within personal space are usually enhanced during the high-estrogen phases (midluteal and preovulatory) of the menstrual cycle, whereas spatial ability is better in the low-estrogen phase...

Stvrtecky, R.C.; Zarate, J.O.; Borgetti, Z.A., 1989: Epithelial adhesion and subperiosteal implants. A case is presented which describes a chromium-cobalt molybdenum alloy maxillary subperiosteal implant which had been removed after two years of successful function for reasons unrelated to the oral environment. The studies performed on a specimen...

Wheatley, B.M., 1953: An electromechanical integrator. British Journal of Radiology 26(307): 382-382

Kondás, O., 1973: Developmental trends of psychotherapy by learning. Ceskoslovenska Psychiatrie 69(1): 39-44

Slikas, A., 1966: Life-cycle of Capillaria bursata Freitas & Almeida, 1934. Direct infection of chicks with Capillaria bursata by means of an 18 to 56-day-old culture of eggs containing larvae did not succeed, but the chicks did become infected when fed with naturally or experimentally infected Eisenia rosea. The eggs bec...