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The neurobiology of X-linked intellectual disability

, : The neurobiology of X-linked intellectual disability. Neuroscientist 19(5): 541-552

X-linked intellectual disability (XLID) affects 1% to 3% of the population. XLID subsumes several heterogeneous conditions, all of which are marked by cognitive impairment and reduced adaptive skills. XLID arises from mutations on the X chromosome; to date, 102 XLID genes have been identified. The proteins encoded by XLID genes are involved in higher brain functions, such as cognition, learning and memory, and their molecular role is the subject of intense investigation. Here, we review recent findings concerning a representative group of XLID proteins: the fragile X mental retardation protein; methyl-CpG-binding protein 2 and cyclin-dependent kinase-like 5 proteins, which are involved in Rett syndrome; the intracellular signaling molecules of the Rho guanosine triphosphatases family; and the class of cell adhesion molecules. We discuss how XLID gene mutations affect the structure and function of synapses.


PMID: 23820068

DOI: 10.1177/1073858413493972

Other references

Waren A., 1980: Descriptions of new taxa of eulimidae mollusca prosobranchia with notes on some previously described genera. Eleven new genera and 17 spp. are described, with one exception parasites on echinoderms: TROCHOSTILIFER, gen. nov., with T. domus sp. nov. (type species) (Philippines) on Stylocidaris effluens, T. mortenseni sp. nov. (New Caledonia) on Prionocida...

Mochida, K.; Ono, Y.; Yamasaki, M.; Shiraki, C.; Hirata, T.; Sato, K.; Okachi, R., 1987: Aminothiazolylglycyl derivatives of carbacephem antibiotics. II. Synthesis and antibacterial activity of novel aminothiazolyl cephem compounds with hydroxypyridone moiety. The synthesis and antimicrobial activity of novel carbacephem antibiotics which have amido moiety of (S)-aminothiazolylglycyl side chain are described. Among them, the compound having 5-hydroxy-4-pyridon-2-carboxyl group (KT-4697) showed exception...

Atashgahi, S.; Lu, Y.; Zheng, Y.; Saccenti, E.; Suarez-Diez, M.; Ramiro-Garcia, J.; Eisenmann, H.; Elsner, M.; J M Stams, A.; Springael, D.; Dejonghe, W.; Smidt, H., 2016: Geochemical and microbial community determinants of reductive dechlorination at a site biostimulated with glycerol. NlmCategory="UNASSIGNED">Biostimulation is widely used to enhance reductive dechlorination of chlorinated ethenes in contaminated aquifers. However, the knowledge on corresponding biogeochemical responses is limited. In this study, gl...

Falandysz, J.; Bielawski, L.; Kawano, M.; Brzostowski, A.; Chudzyński, K., 2002: Mercury in mushrooms and soil from the Wieluńska Upland in south-central Poland. Concentrations of mercury were determined in the fruiting bodies of 15 species of higher mushrooms and underlying soil substrate collected from Wieluńska Upland in northern part of Sandomierska Valley in south-central Poland in 1995. A total of 1...

Kuroda Y.; Kobayashi K.; Kumakura K., 1982: Short term and long term regulation of tyrosine hydroxylase activity by adenosine derivatives in primary culture of bovine adrenal chromaffin cells. Izumi, F , M Oka And K Kumakura (Ed ) Advances in The Biosciences, Vol 36 Synthesis, Storage And Secretion Of Adrenal Catecholamines; Proceedings Of A Satellite Symposium at The 8th International Congress Of Pharmacology, Tokyo, Japan, July 1981 Xv+301p Pergamon Press: Oxford, England; New York, N Y , Usa Illus P195-200

Gupta, A.; Ramakrishna, B., 2014: Hepatic angiomyolipoma: a case report with diagnostic challenge. Angiomyolipomas are rare benign tumors derived from perivascular epithelioid cells that occur frequently in kidney and rarely in the liver. We present a case of hepatic angiomyolipoma, with various clinical and radiological differential diagnoses....

Aono, T.; Kuwajima, I.; Suzuki, Y.; Ozawa, T., 1997: Relation between left ventricular remodeling and nocturnal blood pressure in the elderly with systemic hypertension. Elderly hypertensive patients with concentric left ventricular (LV) hypertrophy had larger LV mass, more impaired diastolic LV function, higher nocturnal blood pressure (BP), and smaller nocturnal BP reduction than those of patients with other geo...

Clària, J.; Lee, M.H.; Serhan, C.N., 1996: Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Background: The mechanism by which aspirin (ASA) acts to protect against human cancer is not yet known. We recently showed that ASA triggers the formation of a new series of potent bioactive eicosanoids, 15-epi-lipoxins (15-epi-LXs or ASA-triggere...

Bottrell Simon H.; Moncaster S.J.; Tellam J.H.; Lloyd J.W., 1998: Controls on sulfate reduction in a dual porosity aquifer. Proceedings - International Symposium on Water-Rock Interaction 9: 207-210

Anonymous, 1980: Use of immunogenetic markers to evaluate bull genotypes. Soviet agricultural sciences: ) 64-66