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The pathogenesis of prostate cancer: from molecular to metabolic alterations

, : The pathogenesis of prostate cancer: from molecular to metabolic alterations. Diagnostic Histopathology 14(5): 195-201

Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiological studies have identified only a handful of candidate genes possibly associated with hereditary or sporadic PCa. Cancer cells often rely for survival on common biochemical pathways such as enhanced anaerobic glycolysis and lipogenesis. The lipogenic enzyme fatty acid synthase seems to play a crucial part in PCa by conferring growth and survival advantages to cancer cells. We summarize the current understanding of the molecular events in PCa, and highlight the importance of altered lipid metabolism in the development and progression of prostate malignancy.


PMID: 20953243

DOI: 10.1016/j.mpdhp.2008.03.001

Other references

Zenke, Y.; Ohara, Y.; Kobayashi, D.; Arai, S.; Kishimoto, M.; Okada, M.; Eto, H., 2017: Nail findings in patients with psoriatic arthritis: A cross-sectional study with special reference to transverse grooves. Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations. This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without art...

Yadav, I.S.; Yadava, T.P., 1996: Genetic analysis and combining ability for seed yield and yield components in toria (Brassica campestris L. var. toria). In a study of 8 x 8 diallel analysis (excluding reciprocals), it was found that both additive and dominance genetic components were important for seed yield and yield components in B. campestris var. toria. However, the magnitude of dominance comp...

Des Jarlais, D.C., 1998: Understanding the long-term course of HIV epidemics. Aids 12(6): 669-670

Ahmad, A.; Modarai, B.; Saha, P.; Burnand, K., 2010: Renal transplantation after excision of the inferior vena cava for residual renal cell carcinoma. A rare case is reported of a 47-year-old patient who had residual tumour left in the stump of his left renal vein and inferior vena cava (IVC) after a left nephrectomy for renal cell carcinoma, having previously had a right nephrectomy for a non-m...

Lakocy, A.; Grabarkiewicz, A., 1974: Some toxicological properties of alternative insecticides for the control of the Colorado beetle, in the light of laboratory investigations. In laboratory investigations on seven insecticides and three mixed preparations commonly used for the control of Leptinotarsa decemlineata (Say), first- and third-instar larvae and overwintered adults were confined on treated potato plants in pots...

Kubera, M.; Grygier, B.; Arteta, B.; Urbańska, K.; Basta-Kaim, A.; Budziszewska, Bława.; Leśkiewicz, M.; Kołaczkowska, E.; Maes, M.; Szczepanik, M.; Majewska, M.; Lasoń, Władysław., 2010: Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. Although recent data may provide theoretical support for the preventive use of antidepressants in cancer patients, so far no study has demonstrated the clinical benefits of such strategies in the general population of cancer patients [39, 41]. Mor...

Staiger, C.J.; Schliwa, M., 1987: Actin localization and function in higher plants. This review summarises current knowledge of actin and associated proteins in plants (including several ornamental, vegetable and field crop species), considers higher plant actomyosin function, and suggests areas deserving future attention.

Bouzegaou, R.; Daeppen, J-Bernard.; Kraemer, K.L., 2014: Acamprosate has not proved to be efficient in the treatment of alcoholism in primary care medicine. Revue Medicale Suisse 9(409): 2308-2309

Gogtay, N.J.; Dalvi, S.S.; Rajgor, D.; Chogle, A.R.; Karnad, D.R.; Ramdas, M.; Aigal, U.; Kshirsagar, N.A., 2003: Diagnostic and prognostic utility of rapid strip (OptiMal and Paracheck) versus conventional smear microscopy in adult patients of acute, uncomplicated P. falciparum malaria in Mumbai, India. The present study compared the diagnostic and prognostic utility of two rapid tests the (Paracheck and OptiMal) versus conventional smear microscopy. Using two independent microscopists we carried out the three tests in 31 adult cases of smear pos...

Toft A.D.; Boyns A.R.; Cole E.N.; Irvine W.J., 1974: Prolactin response to thyrotropin releasing hormone in thyro toxicosis. Journal of Endocrinology 61(3): 515-516