geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The protective effect of oral colitis-derived proteins in a murine model of inflammatory bowel disease is associated with an increase in gammadelta T cells in large intestinal mucosa


, : The protective effect of oral colitis-derived proteins in a murine model of inflammatory bowel disease is associated with an increase in gammadelta T cells in large intestinal mucosa. International Journal of Colorectal Disease 25(9): 1055-1062

Oral tolerance has previously been shown effective in preventing several immune-mediated disorders in animal models. The aims of this study were to investigate the effect of oral colitis-extracted proteins (CEP) on dextran sulfate sodium (DSS)-induced colitis in BALB/c mice and to explore the relative role of the intestinal mucosal gammadelta T cells. The effect of five low oral doses of CEP on colitis was evaluated by clinical manifestation and histological lesions. Serum cytokines were measured by enzyme-linked immunosorbent assay. The percentages of the intestinal mucosal gammadelta T cells were evaluated by flow cytometry. CEP-fed colitis mice showed less severe symptoms and histological injury than bovine serum albumin (BSA)-fed control mice. Tolerized mice developed an increase in TGF-beta1 and no change in IFN-gamma serum levels. Increases in TCRgammadelta(+) T cells and CD8alpha(+)TCRgammadelta(+) T cells in small intestinal mucosal lymphocytes and no quantitative change in large intestinal mucosal lymphocytes were demonstrated in colitis mice compared to untreated mice. The proportions of TCRgammadelta(+) T cells and CD8alpha(+)TCRgammadelta(+) T cells in large intestinal mucosal lymphocytes from CEP-fed colitis mice were significantly higher compared to BSA-fed controls. The disease activity index negatively correlated with the percentages of large intestinal mucosal gammadelta T cells. Furthermore, mucosal repair in repair-period mice was also accompanied by increases in TCRgammadelta(+) T cells and CD8alpha(+)TCRgammadelta(+) T cells in large intestinal mucosal lymphocytes. Improvement of DSS-induced colitis that resulted from oral administration of colitis-extracted proteins is associated with an increase in gammadelta T cells in large intestinal mucosa.

US$19.90

PMID: 20571813

DOI: 10.1007/s00384-010-0975-9


Other references

Khajuee Nejhad, G.; Rezai, A.; Mousavi, S.F., 1994: Effects of different irrigation regimes and planting densities on yield and other characteristics of white bean (line No. 11805). P. vulgaris line 11805 was grown in 1990 at within-row spacings of 10, 20 or 30 cm and irrigated at class A pan evaporations of 50, 70, 90 or 110 mm. The highest and lowest seed yields (2.30 and 0.97 t/ha) were given by irrigation at 70 and 110 mm...

Lilley, R.M.; Chon, C.J.; Mosbach, A.; Heldt, H.W., 1977: The distribution of metabolites between spinach chloroplasts and medium during photosynthesis in vitro. The formation of metabolites in the stroma compartment of isolated chloroplasts [Spinacia oleracea] during carbon fixation, and their export to the medium, were investigated using improved techniques. Rapid separation of photosynthesizing chloropl...

Bourdat-Michel, G.; Bost, M.; Durand, C.; Baudain, P., 1990: Growth hormone deficiency by transection of the pituitary stalk. Value of magnetic resonance imaging. Report of 2 cases. In 2 boys, aged 3 and 13 years, suffering from severe growth failure, endocrine evaluation showed growth hormone deficiency and central hypothyroidism without diabetes insipidus. Magnetic resonance imaging demonstrated a transection of the pituita...

Jacobson E.D., 1969: The blood supply of the stomach. Surgical Clinics of North America 49(3): 559-564

Gutman, J.; Bergmann, F.; Chaimowitz, M.; Costin, A., 1963: The pathway of central nystagmus. Bull Res Counc Israel Sect E Exptl Med 10(3/4): 217

Hafeez, M.A.; Tandon, P.L., 1969: Carcinoma cervix uteri (a clinico-pathological study of 640 cases). Indian Journal of Cancer 6(3): 184-189

Hata, R.; Nagai, Y., 1972: A rapid and micro method for separation of acidic glycosaminoglycans by two-dimensional electrophoresis. Analytical Biochemistry 45(2): 462-468

Langham, M.R.; McPherson, W.W., 1976: Energy analysis. Two species of Drosophila that differ in their ecology and mating systems have been compared with respect to male contribution to the somatic tissues and developing oocytes of females. In the species Drosophila mojavensis females remate daily, exh...

Almeida, Armando J., 1996: Structure and spatial variability of the rocky fish fauna in the protected marine Reserva Natural da Berlenga (Portugal). Arquivos do Museu Bocage Nova Serie. 4 de Maio; 235: 633-642

Harvey, M-Philippe.; Lorrain, D.; Martel, M.; Bergeron-Vezina, K.; Houde, F.; Séguin, M.; Léonard, G., 2017: Can we improve pain and sleep in elderly individuals with transcranial direct current stimulation? - Results from a randomized controlled pilot study. The prevalence of chronic pain and sleep disturbances substantially increases with age. Pharmacotherapy remains the primary treatment option for these health issues. However, side effects and drug interactions are difficult to control in elderly i...