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The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy

, : The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy. Journal of Internal Medicine 269(1): 45-53

Biological therapeutics targeting TNF, IL-1 and IL-6 are widely used for treatment of rheumatoid arthritis, inflammatory bowel disease and a growing list of other syndromes, often with remarkable success. Now advances in neuroscience have collided with this therapeutic approach, perhaps rendering possible the development of nerve stimulators to inhibit cytokines. Action potentials transmitted in the vagus nerve culminate in the release of acetylcholine that blocks cytokine production by cells expressing acetylcholine receptors. The molecular mechanism of this cholinergic anti-inflammatory pathway is attributable to signal transduction by the nicotinic alpha 7 acetylcholine receptor subunit, a regulator of the intracellular signals that control cytokine transcription and translation. Favourable preclinical data support the possibility that nerve stimulators may be added to the future therapeutic armamentarium, possibly replacing some drugs to inhibit cytokines.


PMID: 21158977

DOI: 10.1111/j.1365-2796.2010.02321.x

Other references

Conrad-Dubs, E., 1966: The task of the aging women in the family and in society. Zeitschrift für Krankenpflege. Revue Suisse des Infirmieres 59(3): 188-189

Mendoza, A.; Monroe, R.; Rodriguez, T.; Schanberger, A., 1995: Management of Cape hartebeest antelope (Alcelaphus buselaphus caama) at the Houston Zoological Gardens. American Zoo and Aquarium Association Regional Conference Proceedings, 318-322

Zheng, X.; Sehgal, A., 2013: Speed control: cogs and gears that drive the circadian clock. In most organisms, an intrinsic circadian (?24-h) timekeeping system drives rhythms of physiology and behavior. Within cells that contain a circadian clock, specific transcriptional activators and repressors reciprocally regulate each other to gen...

Ochetim, S., 1992: The substitutability of maize with cassava root and leaf meal mixture in broiler diets. Two experiments were conducted to investigate into the effects of replacing maize with a mixture of cassava root and leaf meal (CRLM) on the performance of broiler chickens. In experiment 1, CRLM replaced 50 to 100 percent of maize in the control...

Bou Ali, M.; Jallouli, R.; Gargouri, Y.; Ben Ali, Y., 2016: Evaluation of the recombinant turkey pancreatic lipase phospholipase activity: A monolayer study. Classical lipases are well known for being enzymes hydrolysing triacylglycérols as substrate, except the porcine pancreatic lipase (PPL) which was able to hydrolyze phosphatidylcholine. Amino acid sequence alignments revealed that Valine 260 resi...

Phelps, P.D., 1999: The common cavity deformity of the ear. A precursor of meningitis but now being implanted. The first succinct description of otogenic meningitis related to the common cavity deformity of the inner ear was made from a post mortem study of 150 years ago. Since then there has been much confusion with less severe malformations of the cochle...

Skot L., 1988: Insertion of tn5mob into cryptic plasmid of a rhizobium leguminosarum strain gives it a fix minus phenotype. Bothe, H , F J De Bruijn And W E Newton (Ed ) Nitrogen Fixation: Hundred Years After; 7th International Congress, Cologne, West Germany, March 13-20, Xxi+878p Vch Publishers, Inc : New York, New York, Usa; Vch Verlagsgesellschaft Mbh: Weinheim, West Germany; Gustav Fischer Verlag: Stuttgart, West Germany Illus 385

Koprowski H., 1978: Detection of defective or uninducible herpes simplex virus genomes latent in human trigeminal ganglion explants. Heredity: 332

Malek, N.P.; Schmidt, S.; Huber, P.; Manns, M.P.; Greten, T.F., 2015: The diagnosis and treatment of hepatocellular carcinoma. The incidence of hepatocellular carcinoma (HCC) has continued to rise in recent years. This increase has been attributed to alcohol-induced liverdiseases, metabolic syndrome, and the rising number of hepatitis B and C viral infections. Pertinent p...

Darby, B.J.; Herman, M.A., 2014: Effect of prey richness on a consumer's intrinsic growth rate. The intrinsic growth rate of non-selective microbivores increases asymptotically with increasing prey biomass, but we do not know how intrinsic growth rate is affected by prey richness. The objective of this experiment was to determine the effect...