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The regulation of Th1 responses by the p38 MAPK

, : The regulation of Th1 responses by the p38 MAPK. Journal of Immunology 185(10): 6205-6213

IL-12 is a dimeric cytokine that is produced primarily by APCs. In this study we examined the role that the p38 MAPKs (MAPK/p38) play in regulating IL-12 production. We show that inhibition of p38 dramatically increased IL-12 production upon stimulation, while decreasing TNF-α. This reciprocal effect on these two cytokines following MAPK/p38 inhibition occurred in many different APCs, following a variety of different stimuli. IL-12 production was also increased in macrophages treated with small interfering RNA to limit p38α expression, and in macrophages deficient in MKK3, a kinase upstream of p38. The increase in IL-12 production following MAPK/p38 inhibition appears to be due to enhanced IL-12 (p40) mRNA stability. We show that MAPK/p38 inhibition can promote Th1 immune responses and thereby enhance vaccine efficacy against leishmaniasis. In a mouse model of Leishmania major infection, vaccination with heat-killed L. major plus CpG and SB203580 elicited complete protection against infection compared with heat-killed L. major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens.


PMID: 20937847

DOI: 10.4049/jimmunol.1000243

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Gonzalez, F.; Trujillo, J.M.; Alexanian, R., 1977: Acute leukemia in multiple myeloma. Of 476 patients with multiple myeloma treated during a 9-year period, 11 developed acute myelogenous leukemia or sideroblastic anemia. In all, the myeloma was in remission from chemotherapy with melphalan-prednisone combinations that had been cont...

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Edvinsson, L.; Cantera, L.; Jansen Olesen, I.; Uddman, R., 1997: Expression of calcitonin gene-related peptide-1 receptor mRNA in human trigeminal ganglia and cerebral arteries. Reverse transcriptase polymerase chain reaction (RT-PCR) using primers for the recently cloned human CGRP-1 receptor detected mRNA expression of CGRP-1 receptors in trigeminal ganglia and cerebral vessels, obtained at autopsy or during neurosurgic...

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Kholdin, S.A.; Prokof'eva, O.G., 1963: Protocol of the 74th conference of the Scientific Society of Oncologists of Leningrad and the Leningrad oblast, Leningrad, USSR, January, 1963. A review of the 2 demonstrations and 2 papers presented at the meeting. The main topics were: the stable results of radiation therapy of skin carcinoma which developed after long-standing lupus; the immediate results of combined treatment of bronc...

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