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The regulation of Th1 responses by the p38 MAPK


, : The regulation of Th1 responses by the p38 MAPK. Journal of Immunology 185(10): 6205-6213

IL-12 is a dimeric cytokine that is produced primarily by APCs. In this study we examined the role that the p38 MAPKs (MAPK/p38) play in regulating IL-12 production. We show that inhibition of p38 dramatically increased IL-12 production upon stimulation, while decreasing TNF-α. This reciprocal effect on these two cytokines following MAPK/p38 inhibition occurred in many different APCs, following a variety of different stimuli. IL-12 production was also increased in macrophages treated with small interfering RNA to limit p38α expression, and in macrophages deficient in MKK3, a kinase upstream of p38. The increase in IL-12 production following MAPK/p38 inhibition appears to be due to enhanced IL-12 (p40) mRNA stability. We show that MAPK/p38 inhibition can promote Th1 immune responses and thereby enhance vaccine efficacy against leishmaniasis. In a mouse model of Leishmania major infection, vaccination with heat-killed L. major plus CpG and SB203580 elicited complete protection against infection compared with heat-killed L. major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens.

US$19.90

PMID: 20937847

DOI: 10.4049/jimmunol.1000243


Other references

Gonzalez, F.; Trujillo, J.M.; Alexanian, R., 1977: Acute leukemia in multiple myeloma. Of 476 patients with multiple myeloma treated during a 9-year period, 11 developed acute myelogenous leukemia or sideroblastic anemia. In all, the myeloma was in remission from chemotherapy with melphalan-prednisone combinations that had been cont...

Bonanno; Xu; Camarca; Siciliano; Oliva, 1990: Angle-resolved Auger study of 10-keV Ar+-ion-induced Si LMM atomic lines. Physical Review. B, Condensed Matter 41(18): 12590-12598

Negru-Subtirica, O.; Tiganasu, A.; Dezutter, J.; Luyckx, K., 2016: A cultural take on the links between religiosity, identity, and meaning in life in religious emerging adults. Identity and meaning in life are core developmental assets in emerging adulthood. We analysed how religiosity is related to these intentional strivings in emerging adults enrolled in theological education, by depicting (1) identity strivings and m...

Edvinsson, L.; Cantera, L.; Jansen Olesen, I.; Uddman, R., 1997: Expression of calcitonin gene-related peptide-1 receptor mRNA in human trigeminal ganglia and cerebral arteries. Reverse transcriptase polymerase chain reaction (RT-PCR) using primers for the recently cloned human CGRP-1 receptor detected mRNA expression of CGRP-1 receptors in trigeminal ganglia and cerebral vessels, obtained at autopsy or during neurosurgic...

Anonymous, 2002: 2nd Australian Lettuce Industry Conference, Paddock to Plate, Gatton, Queensland, Australia, 5-8 May, 2002. This publication contains the proceedings of the 2002 Australian Lettuce Industry Conference consisting of 15 papers on lettuce production; pests (Heliothis and Helicoverpa), pathogens and disorders, and their control; storage; variety trials; and...

Kholdin, S.A.; Prokof'eva, O.G., 1963: Protocol of the 74th conference of the Scientific Society of Oncologists of Leningrad and the Leningrad oblast, Leningrad, USSR, January, 1963. A review of the 2 demonstrations and 2 papers presented at the meeting. The main topics were: the stable results of radiation therapy of skin carcinoma which developed after long-standing lupus; the immediate results of combined treatment of bronc...

Denis, J., 1957: Males et femelles d'araignees. Bulletin de la Societe Entomologique du Nord de la France, 89: 1-3

Boussoualem, M.; Roussel, Fédérick.; Ismaili, M., 2004: Thermophysical, dielectric, and electro-optic properties of nematic liquid crystal droplets confined to a thermoplastic polymer matrix. The thermophysical, dielectric and electro-optic properties of polymer-dispersed liquid crystal (PDLC) films made of monodisperse polystyrene (PS) and 4-n-pentyl-4(')-cyanobiphenyl (5CB) are investigated by polarized optical microscopy, diffe...

Soldatini, Gf, 1985: Plant-water relations and cereal productivity. Ricerca applicata ed esportazione del prodotto industriale: II Giornate internazionali sul grano duro: Foggia 2-3 maggio 1985 redazione atti Istituto sperimentale per la cerealicoltura: 163

Hirai, H.; Ichikawa, K.; Kojima, N.; Nishida, H.; Satake, K.; Yoshikawa, N., 2000: 5-Substituted picolinic acid compounds and their production process. The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 and R2 are independently H, C2 -C6 acyl or halo-substituted benzoyl; and R3 is --C(O)O--C...