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The role of cholesterol and statins in stroke

, : The role of cholesterol and statins in stroke. Current Cardiology Reports 11(1): 4-11

Flawed observational studies find weak associations between high cholesterol and ischemic stroke, and low cholesterol and hemorrhagic stroke. Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides each appear to have individual effects on stroke risk and type. Statins decrease the risk of cerebral infarction in patients with coronary disease, diabetes, hypertension, and hypercholesterolemia. They also significantly decrease the risk of ischemic stroke in patients with recent cerebrovascular disease, while potentially increasing the risk of intracerebral hemorrhage. Lower achieved cholesterol values are associated with greater reductions in stroke risk. Besides their cholesterol-lowering properties, statins are also pleiotropic agents with various neuroprotective mechanisms. Neurologic disability and infarct size are decreased in patients administered statins during stroke. Mortality and neurologic deterioration are higher in patients with statin cessation during acute ischemic stroke. Cholesterol is a modifiable risk factor for stroke, and statins are excellent agents for prophylaxis and acute therapy.


PMID: 19091169

Other references

Mariau, D., 1968: Biology of the feeding habits of Oryctes. Oryctes monoceros and O. boas in coconut palms were studied. The site of attack was found to vary with plant age; nursery plants were almost always attacked at collar level, and on 1-year-old palms 65% of beetles attacked at the leaf axil (leaves...

Singer, J.; Russi, C.; Taylor, J., 2005: CME single-use antibiotics for the pediatric patient in the emergency department. Pediatric Emergency Care 21(1): 50-59

Stalder, M.P.; Rovó, A.; Halter, Jörg.; Heim, D.; Silzle, T.; Passweg, J.; Rischewski, J.; Stern, M.; Arber, C.; Buser, A.; Meyer-Monard, S.; Tichelli, Aé.; Gratwohl, A., 2009: Aplastic anemia and concomitant autoimmune diseases. The association of aplastic anemia (AA) with other autoimmune diseases (AID) has been described but so far not systematically evaluated. We assessed the incidence and the outcome of concomitant AID in a retrospective, single-center study of 243 pa...

Tsuji, T.; Weissmann, J., 1977: Genetical investigation of adenylate kinase in the population of the Lübeck area using agarose-thin-layer electrophoresis. Adenylate kinase phenotypes were determined in a sample of 604 persons in the vicinity of Lübeck by means of thin-layer agarose-electrophoresis: A gene frequency of 0,9577 was estimated for AK1 and 0.0423 for AK2.

Kawashiro, I.; Kawada, K.; Amano, R., 1961: 4-(Pyridylazo)-resorcinol as an analytical reagent for the colorimetric determination of lead in food. Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 79: 87-89

H.W.nwu; Zhang Wenhuai, 1993: Physical-chemical conditions for the ore-forming process of the Hetai gold deposit in Guangdong and ore-prospecting directions. Mineral Deposits = K'uang Ch'uang Ti Chih / Kuangchuang Dizhi 12(2): 120-128

Haustein, K.O.; Thiele, G.; Stangel, U., 1994: Transport of various substances through human enamel and dentine. The penetration of 14C-labelled alcohols (methanol, ethanol, n-butanol), 14C-labelled carbonic acids (formic, acidic, propionic, valerianic, octanoic, malonic, succinic and lactic acid), 14C-drugs (procaine, barbital), and 14C-sugars (saccharose,...

Coyle, KO., 1998: Neocalanus scattering layers near the western Aleutian Islands. Journal of Plankton Research. June; 206: 1189-1202

Popov, V.L., 2013: Diagnosis in forensic medical practice. The author performed the analysis of the essence and patogenetic structure of diagnosis in forensic medical practice, the similarities and differences between forensic medical, pathological morphological, and clinical diagnoses, and their signific...

Kasza, J.; Wolfe, R.; Schuster, T., 2017: Assessing the impact of unmeasured confounding for binary outcomes using confounding functions. A critical assumption of causal inference is that of no unmeasured confounding: for estimated exposure effects to have valid causal interpretations, a sufficient set of predictors of exposure and outcome must be adequately measured and correctly i...