geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of cholesterol efflux in mechanisms of endothelial protection by HDL


, : The role of cholesterol efflux in mechanisms of endothelial protection by HDL. Current Opinion in Lipidology 23(3): 182-189

HDL and their main apolipoprotein (apo) constituent apoA-I are antiatherogenic. This has been predominantly attributed to the ability of apoA-I/HDL to efflux cholesterol from macrophages within atherosclerotic plaques. It is now emerging that a number of the protective properties of HDL may be due to their effects on the endothelium. In addition to their well characterized anti-inflammatory and antioxidant effects, apoA-I and HDL regulate several other key biological pathways known to preserve endothelial function and promote vascular repair. The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the scavenger receptor B type 1 mediate multiple intracellular signaling pathways as well as the efflux of cholesterol and/or oxysterols in response to apoA-I/HDL. Although cholesterol efflux triggers a host of signaling events in endothelial cells, there is evidence that some of the beneficial actions of HDL may occur independently of efflux. Current data suggest that in endothelial cells ABCA1 and ABCG1 mediate the activation of intracellular signaling pathways primarily through the efflux of cholesterol and oxysterols to apoA-I/HDL. Interaction between HDL and scavenger receptor B type 1 initiates the greatest number of known signaling pathways and there is evidence that some of these are activated independent of efflux.

US$19.90

PMID: 22488423

DOI: 10.1097/MOL.0b013e328352c4dd


Other references

Oranskiĭ, I.E.; Guliaev, V.Iu.; Obraztsova, R.G.; Zolotovitskaia, A.E.; Tret'iakova, L.F., 1983: New variant of electrophoresis. Voprosy Kurortologii, Fizioterapii, i Lechebnoi Fizicheskoi Kultury: 15-18

Helmeste, D.M.; Fang, H.; Li, M.; Tang, S.W., 1996: Multiple 3H-nemonapride binding sites in human and cow brain. Society for Neuroscience Abstracts 22(1-3): 828

Seligmann, B.E.; Fletcher, M.P.; Gallin, J.I., 1983: Histamine modulation of human neutrophil oxidative metabolism, locomotion, degranulation, and membrane potential changes. Previous reports have suggested that histamine modulates neutrophil chemotaxis, but this has not been observed by all laboratories. We have re-addressed this controversial point and demonstrate that histamine and H1- and H2-receptor-specific agoni...

Bazelly, B.; Benomar, M.; Gaillard, D.; Andrivet, S.; Vanetti, A., 1983: Surgical management of five cases of cardiac hydatidosis. The management of 5 cases of cardiac hydatidosis operated on under conditions of extracorporeal circulation is summarized.

Ims, R.A.; Fuglei, E., 2005: Trophic Interaction Cycles in Tundra Ecosystems and the Impact of Climate Change. While population cycles are geographically widespread, it is on arctic tundra that such cycles appear to be most influential for the functioning of the whole ecosystem. We give an overview of tundra species that exhibit population cycles and descr...

Amundson, R.; Barnes, J.D.; Ewing, S.; Heimsath, A.; Chong, G., 2011: The stable isotope composition of chlorine in hyperarid soils. Halite (NaCl) is a water soluble mineral found in soils of the driest regions of Earth, and only modest attention has been given to the hydrological processes that distribute this salt vertically in soil profiles. The recent application of stable...

Harris, M.; Hartley, A.L.; Blair, V.; Birch, J.M.; Banerjee, S.S.; Freemont, A.J.; Mcclure, J.; Mcwilliam, L.J., 1991: Sarcomas in north west england uk i. histopathological peer review. A total of 468 cases of bone, soft tissue and visceral sarcomas (and certain other tumors) diagnosed during the years 1982-84 in North West England were entered in a study of histopathological peer review, incidence and survival. This paper descri...

Czekalla, Jörg.; Wagner, T.; Schacht, A.; Kluge, M.; Kinon, B., 2007: Effectiveness and medication acceptance of olanzapine disintegrating tablets compared to standard olanzapine tablets in acutely treated psychiatric patients. This study compared effectiveness and acceptance of orally disintegrating olanzapine tablets (ODT) with standard-coated tablets (SOT) in acutely ill psychiatric patients admitted to psychiatric hospitals for emergency treatment. Large, prospective...

Tanaka, K.; Tanaka, M.; Sugiyama, T., 2006: Creation of strongly localized and strongly enhanced optical near-field on metallic probe-tip with surface plasmon polaritons. A practical technique by which a strongly confined and strongly enhanced optical near-field can be created on a metallic probe-tip is investigated. The technique uses an I-shaped aperture in a pyramidal structure formed on a thick metallic screen....

Delakas, D.; Daskalopoulos, G.; Karyotis, I.; Metaxari, M.; Cranidis, A., 2002: Giant ureteral stone in association with primary megaureter presenting as an acute abdomen. A 20-year-old woman presented with abdominal pain of 4-h duration and of sudden onset. A plain abdominal radiograph showed a giant ureteral stone measuring 12 cm causing ureteral obstruction. Abdominal ultrasound revealed severe dilatation of the...