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The role of dendritic cells in multiple sclerosis


, : The role of dendritic cells in multiple sclerosis. Current Neurology and Neuroscience Reports 7(3): 245-252

Although multiple sclerosis (MS) is a presumed T-cell- mediated disease, it is unclear what triggers the development of neuroantigen-specific T cells. Autoreactive CD4(+) T cells are activated by antigen presenting cells; dendritic cells (DCs) are the primary antigen presenting cells directing T-cell functions and are, therefore, extremely important in directing the immune pathology characteristic of MS. Three important concepts have emerged regarding DCs in MS. First, DCs are present within the healthy central nervous system (CNS) in association with the cerebrospinal fluid space and microvasculature. Therefore, the potential for sampling of CNS antigens in similar fashion to other tissues and organs exists and likely plays an integral role in CNS immunity. The degree of involvement, as well as the source, of these CNS DCs has been addressed by several studies using the experimental autoimmune encephalomyelitis animal model. Second, DCs are found within MS lesions and have been shown to be functionally abnormal in patients with MS. Lastly, therapeutics directed at DCs could potentially be engineered for treatment in MS and in fact may already be involved in the mechanisms of current immunomodulatory therapies.

US$29.90

PMID: 17488591


Other references

Ding, F.; Liu, W.; Diao, J-Xiong.; Sun, Y., 2011: Characterization of Alizarin Red S binding sites and structural changes on human serum albumin: a biophysical study. Alizarin Red S (ARS), is a water-soluble, widely used anthraquinone dye synthesized by sulfonation of alizarin. In this report, the binding of ARS to human serum albumin (HSA) was characterized by employing fluorescence, UV/vis absorption, circula...

Kaufmann, O.K., 1960: Milk and dairy regulations. A detailed survey of Swiss legislation relating to milk and dairy products. The marketing regulations include a guaranteed price, but also stringent requirements as to the quality of the products. The Swiss 'Landwirtschaftsgesetz' recogn...

Lacević, N.; Vukobrat-Bijedić, Z.; Husić-Selimović, A.; Mesihović, R.; Gornjaković, S.; Prohić, D., 2004: Imaging procedures in gastroenterology. Recent achievements in fields of physics, microelectronical devices and informatical sciences opened huge possibilities of applications in medical specialities. Spread imaging over routine high-resolution instruments continue to be in focus of sci...

Zhang, H.; Yi, M.; Zhang, Y.; Jin, H.; Zhang, W.; Yang, J.; Yan, L.; Li, R.; Zhao, Y.; Qiao, J., 2016: High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS. Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder with unclear etiology and unsatisfactory management. Effects of diets on the phenotype of PCOS were not fully understood. In the present study, we applied 45 and 60% hi...

Das, S.K.; Banerjee, A.B., 1981: Effect of undecanoic acid on cell permeability and respiration of Trichophyton rubrum. Undecanoic acid at 15 and 30 mu g/ml inhibited both endogenous respiration and oxidation of exogenous glucose by T. rubrum. Significant amounts of cell leakage occurred only when undecanoic acid conc. was raised above 80 mu g/ml.

Jiang, Y.; Zhao, E., 1983: Studies on amphibians and reptiles of Mt. Gongga region, Sichuan, China. 3. A study of species-group nuchalis, genus Rhabdophis. Acta Herpetologica Sinica, 21: 59-62

Takayama, H.; Nishimura, K.; Tsujimura, A.; Nakai, Y.; Nakayama, M.; Aozasa, K.; Okuyama, A.; Nonomura, N., 2009: Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation. Tumor associated macrophages can regulate the growth of various cancers positively or negatively. Intravesical bacillus Calmette-Guerin instillation is now gold standard treatment for bladder carcinoma in situ. We investigated the correlation betw...

Llamas R.; Galera H.; Matilla A.; Mendez J.A.; Gonzalez Campora R., 1979: Critical analysis of the morphological criteria for the differential diagnosis of cholestasis. Pathology Research & Practice 165(1-2): 116

Chu Y.E.; Jiang Y.M.; Yang Y.C.; Losa W.T.; Chang C.; Kuo S.T.; Wang S.Y., 1982: Sensitivity tests on mycobacterium tuberculosis using the rapid radiometric method. Bulletin of the International Union Against Tuberculosis 57(1): 53

Fabius, D.B.; Rein, A., 1990: Intravenous amrinone therapy: nursing implications. Intravenous amrinone (Inocor) is the latest in a line of cardiotonic agents approved for the treatment of heart failure. A thorough knowledge of the pharmacology of this agent is essential in the development of a plan of care for this critically i...