geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of hypomethylating agents in the treatment of elderly patients with AML


, : The role of hypomethylating agents in the treatment of elderly patients with AML. Journal of Geriatric Oncology 5(1): 89-105

There is a major unmet medical need for treatment options in elderly patients with acute myeloid leukemia (AML) who are deemed ineligible for intensive treatment. The recent approval of decitabine in the European Union for the treatment of patients with AML≥ 65 years old highlights the potential for hypomethylating agents in this setting. Here, we review evidence to support the use of hypomethylating agents in elderly patients and emphasize the importance of tolerability and quality of life considerations. We focus on the rationale for the continued clinical development of the ribonucleoside analog azacitidine in this setting. We discuss potential differences in the activity of azacitidine and decitabine in different patient subgroups that could possibly be explained by important differences in mechanism of action. Finally, we assess practical challenges that will be faced when integrating hypomethylating agents into clinical practice, such as how to define ineligibility for intensive treatment.

US$19.90

PMID: 24484723

DOI: 10.1016/j.jgo.2013.08.004


Other references

Loan Thi Kim Ho, Yasushi Yamaguchi, Masatomo Umitsu, 2013: Delineation of small-scale landforms relative to flood inundation in the western Red River delta, northern Vietnam using remotely sensed data. Flood susceptibility mapping using geomorphologic approaches is effective for delineating flood extent and various degrees of potential flood-affected areas. This approach is useful where the channel system and floodplain morphology change dynamic...

Saravanan Nagappan, Myeon-Cheon Choi, Giju Sung, Sung Soo Park…, 2013: Highly transparent, hydrophobic fluorinated polymethylsiloxane/silica organic-inorganic hybrids for anti-stain coating. Organic-inorganic hybrids were synthesized using polymethylhydrosiloxane, 2,2,3,4,4,4 hexafluorobutylmethacrylate and tetraethyl orthosilicate with a platinum catalyst. The resulting hybrids formed transparent thin films on glass substrate by spin...

da Veiga, F.Alte.; Saraiva, C.Braz., 2003: Age patterns of suicide: identification and characterization of European clusters and trends. Relatively few studies have addressed age patterns of suicide using specifically designed and systematized approaches. Our main objective was to identify and characterize age patterns of suicide in Europe, both on cross-sectional and longitudinal...

Shimomura, M.; Hinoi, T.; Ikeda, S.; Adachi, T.; Kawaguchi, Y.; Tokunaga, M.; Sasada, T.; Egi, H.; Tanabe, K.; Okajima, M.; Ohdan, H., 2013: Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery. Postoperative adhesion formation is regulated by peritoneal fibrinolysis, which is determined by tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1). This study compared peritoneal fibrinolysis and adhesion format...

Fishburn, C.Simone; Herzmark, P.; Morales, J., 1999: Gbc and palmitate target newly synthesized Gaz to the plasma membrane. The Journal of Biological Chemistry 274(26): 793-800

Sivaraju, L.; Thakar, S.; Hegde, A.S., 2016: Visual Deterioration and Herniation of the Anterior Cerebral Artery: Unusual Presentation of an Empty Sella Syndrome Complicating Decompression of a Rathke Cleft Cyst. Clinical manifestations of empty sella syndrome include hypopituitarism cerebrospinal fluid rhinorrhea, headache, and visual abnormalities. A 21-year-old woman reported a 6-month history of worsening vision 3 years after decompression of a sellar-...

Mcchesney, Evan W., 1945: Further studies on the detoxication of the arsphenamines by ascorbic acid. The study represents an investigation of the mechanism whereby ascorbic acid achieves a 50% reduction in the toxicity of neoarsphen-amine. An analytical procedure was developed for the analysis of oxygenated solns. of the arsenical, and it was fou...

Ogita, H.; Node, K.; Kitakaze, M., 2003: The role of estrogen and estrogen-related drugs in cardiovascular diseases. The cardiovascular effects of estrogen have recently become a focus of basic and clinical cardiovascular medicine because of the multiplicity of its beneficial effects. Various basic and clinical studies have revealed that estrogen has potent card...

Parsons, S.; Doyle, J., 2001: Struvite recovery and reuse. Magnesium ammonium phosphate (struvite) is formed during processing of sludges formed during biological nutrient removal in wastewater treatment plants. Struvite has a potential use as a fertilizer. Chemical principles of struvite, and its recover...

Korim Michal, 1975: Large antimony deposit in Kremnica. Mineralia Slovaca 7(1-2): 99-103