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The role of neuroimaging in our understanding of the suicidal brain


, : The role of neuroimaging in our understanding of the suicidal brain. Cns & Neurological Disorders Drug Targets 12(7): 921-929

This paper provides a review of the literature on neuroimaging studies of suicidal behaviour, and discusses the relevance of these studies for our understanding of suicidal behaviour. Main findings from molecular imaging studies include a reduced prefrontal perfusion or metabolism and a blunted increase in activation when challenged in association with a history of suicide attempts. Moreover, impairment of the prefrontal serotonergic system in association with suicidal behaviour is demonstrated in a number of studies. Recent structural and functional imaging studies show changes in cortical and subcortical areas and their connections. A number of methodological issues hamper the interpretation of findings. Nevertheless, when findings from studies using divergent techniques are taken together there is increasing evidence of the involvement of a fronto-cingulo-striatal network in suicidal behaviour. This involvement is supported additionally by findings from neuropsychological studies, which demonstrate changes in decision-making processes in association with suicidal behaviour that rely on the same network. Further study is needed to translate the increasing knowledge from neuroimaging studies in clinical tools for the prediction and prevention of suicidal behaviour.

US$29.90

PMID: 24040805


Other references

Zhang, S.; Yuan, K., 1987: Archaeocyathida. Unknown

Sahi, J.; Stobbe, H.; Klatt, R., 1972: The azurophilic granules of lymphocytes in the aged. Zeitschrift für Alternsforschung 26(1): 49-50 Passim

Maclean, GL., 1984: Ornithological research in southern Africa. Unknown

Hafez, R.; Labat, R.; Quillier, R., 1978: Nuclear dna content and evolutive relationships in the cyprinidae family teleostei. Fish of the following species were collected in the Garonne river basin and their DNA was quantitatively studied by comparative histophotometry after the Feulgen-Rossenbeck reaction, with human erythrocytes serving as the reference: Rutilus rutilu...

Langer P.; Foldes O.; Gschwendtova K., 1984: Comparison of biliary excretion of iodothyronines after intravenous and intraduodenal administration of various doses of thyroxine and triiodothyronine. Intraduodenal 10 or 40 .mu.g thyroxine (T4) and 5 or 10 .mu.g triiodothyronine (T3) or i.v. bolus of 2, 4 or 8 .mu.g T4 or infusion of 10 .mu.g T4 within 2 h were administered to groups of 3-5 rats. All experiments were made under pentobarbiturate...

Ktenidis, K.; Lioupis, A.; Megalopoulos, A.; Antoniadis, K.; Kiskinis, D., 2011: New exposure technique for management of giant internal carotid artery aneurysm. We are presenting a case of giant internal carotid artery aneurysm (ICAA) managed by a new exposure technique. Following double mandibular osteotomy, the exposure of the entire aneurysm was achieved by mandible mobilization. The aneurysm repair wa...

Wahl, L.M.; Gerrish, P.J., 2001: The probability that beneficial mutations are lost in populations with periodic bottlenecks. Population bottlenecks affect the dynamics of evolution, increasing the probability that beneficial mutations will be lost. Recent protocols for the experimental study of evolution involve repeated bottlenecks[-]when fresh media are inoculated dur...

Luchtman, D.W.; Shao, D.; Song, C., 2009: Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. Three common dosing regimens of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of Parkinson's disease (PD) were compared in C57BL/6 mice on behavior, striatal and extra-striatal neurotransmission, and brain cytokines, t...

Graham, R., 1930: Bird notes from the Solway Firth 1928 pp 167-177, 231-235 Migration of Bar-tailed Godwits and other Waders over Cumberland pp 180-181. North Western Naturalist Arbroath, 5

Herek, G.M., 1989: Hate crimes against lesbians and gay men. Issues for research and policy. Antigay hate crimes (words or actions that are intended to harm or intimidate individuals because they are lesbian or gay) constitute a serious national problem. In recent surveys, as many as 92% of lesbians and gay men report that they have been...